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Universal vaccine advancement through AI and recombinant technology

In this interview, News-Medical talks to Dr. Amy Sheng and Dr. Lurong Pan about how AI computing can be used in combination with high throughput production and screening to enhance the development process for potential universal vaccines.

From Sino Biological Inc. 3 Oct 2022

Novel peanut-specific human IgE monoclonal antibodies may uncover new therapeutic targets for peanut allergy

A recent Frontiers in Immunology journal study by University of North Carolina at Chapel Hill and Vanderbilt University researchers has created an in vitro system to determine potential therapeutics targeting sensitized effector cells based on human, allergen-specific, Immunoglobulin E (IgE) monoclonal antibodies (mAbs).

2 Oct 2022

Broadly neutralizing antibodies are the blueprint for variant-proof, pansarbecovirus vaccines

A recent Nature Reviews Immunology study has summarized the efficacy of neutralizing antibodies that target four main regions of the spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), namely, the receptor-binding domain (RBD) in the S1 subunit, the fusion peptide region in the S2 subunit, the stem helix region, and the N-terminal domain.

2 Oct 2022

Novel technique helps to detangle how phosphorylation regulates cellular events

Each day, millions of biological processes occur in our body at a cellular level. Studying these processes can help us learn more about how cells function, a field that has continued to intrigue researchers.

30 Sep 2022

The sexual dimorphisms in the epidemiology and pathophysiology of obesity

Researchers reviewed the sexual dimorphisms in obesity.

30 Sep 2022

Brazilian study reveals the effects of SARS-CoV-2 infection on the central nervous system

A Brazilian study published in the journal PNAS describes some of the effects infection by SARS-CoV-2 can have on the central nervous system.

30 Sep 2022

Research may lead to safer ways to care for patients impacted by blood clots

A nanoparticle therapy developed by investigators at University Hospitals (UH) and Case Western Reserve University targets overactive neutrophils, a specific kind of white blood cell, to prevent almost all types of blood clots while causing no increased risk for bleeding.

30 Sep 2022

Research sheds light on how the cell selects suitable protein fragments for robust T-cell response

As task forces of the adaptive immune system, T lymphocytes are responsible for attacking and killing infected or cancerous cells.

30 Sep 2022

Obscure family of viruses already endemic in African monkeys "poised for spillover" to humans

An obscure family of viruses, already endemic in wild African primates and known to cause fatal Ebola-like symptoms in some monkeys, is "poised for spillover" to humans, according to new University of Colorado Boulder research published online Sept. 30 in the journal Cell.

30 Sep 2022

The compositional and functional diversity of the gut fungal microbiome

Researchers assessed the role of gut bacterial microbiome assembly and the gut mycobiome in relation to health, pathology, and clinical applications.

30 Sep 2022

SARS-CoV-2 spike protein and messenger ribonucleic acid found to translocate into the nucleus

In a new study, researchers reported severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) spike (S) protein and S messenger ribonucleic acid (mRNA) nuclear co-translocation as a novel feature of SARS-CoV-2 pathogenesis.

30 Sep 2022

Plasma proteome signature predictive of occurrence of persistent symptoms following SARS-CoV-2 infection

In a new study, researchers performed a proteomic multiple-reaction monitoring analysis of 91 pre-selected proteins using the plasma samples of 156 healthcare workers (HCW) in the United Kingdom (UK).

30 Sep 2022

High-resolution pangenome dataset provides genetic insights into domestic and wild silkworm

BGI Genomics, in collaboration with Southwest University, the State Key Laboratory of Silkworm Genome Biology, and other partners, has constructed a high-resolution pangenome dataset representing almost the entire genomic content in a silkworm.

30 Sep 2022

What is the efficacy of curcumin as a photosensitizer, prophylactic and therapeutic agent against SARS-CoV-2?

In a new study, researchers investigated the efficacy of curcumin as a blue light photosensitizing agent for photodynamic therapy (PDT), as a prophylactic agent, and as a therapeutic agent against SARS-CoV-2.

30 Sep 2022

Effectiveness of anti-SARS-CoV-2 immunoadhesin against omicron and other emerging variants

A new study demonstrated the efficacy of a newly engineered angiotensin-converting enzyme 2 (ACE2) based immunoadhesin against Omicron and other SARS-CoV-2 VOCs.

30 Sep 2022

Oxytocin induces epicardial cell proliferation, study finds

The neurohormone oxytocin is well-known for promoting social bonds and generating pleasurable feelings, for example from art, exercise, or sex. But the hormone has many other functions, such as the regulation of lactation and uterine contractions in females, and the regulation of ejaculation, sperm transport, and testosterone production in males.

30 Sep 2022

Patients with scleroderma have reduced levels of Cathepsin L

Much of the research on scleroderma, a connective tissue disease that causes scarring, or fibrosis, has focused on the increased number of proteins promoting fibrosis in these patients. A Medical University of South Carolina (MUSC) research team took a different tact and measured the levels of an antifibrotic protein, Cathepsin L, in these patients.

30 Sep 2022

Study reveals the role of autophagy in competitive elimination of cancer cells

Elimination of transformed cells that can initiate cancer is necessary to maintain tissue integrity. In a new study, scientists from Tokyo University of Science show how this mechanism is regulated by the cellular process “autophagy.”

30 Sep 2022

Love hormone can activate heart repair mechanisms after cardiac injury, study finds

Researchers show for the first time that the neurohormone oxytocin has a previously unsuspected function in both zebrafish and human cell cultures: it stimulates mature cells in the epicardium of the heart to become stem-like cells, which can replace heart cells lost after damage.

30 Sep 2022

Bioactive compounds derived from Ganoderma lucidum exhibit anti-SARS-CoV-2 activity

Scientists have identified lucidenic acid A, one of the bioactive compounds of Ganoderma lucidum, as a potential inhibitor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) host cell entry. The study has recently been published in the journal Food and Chemical Toxicology.

29 Sep 2022

B Cell News and Research

Universal vaccine advancement through AI and recombinant technology

Novel peanut-specific human IgE monoclonal antibodies may uncover new therapeutic targets for peanut allergy

Broadly neutralizing antibodies are the blueprint for variant-proof, pansarbecovirus vaccines

Novel technique helps to detangle how phosphorylation regulates cellular events

The sexual dimorphisms in the epidemiology and pathophysiology of obesity

Brazilian study reveals the effects of SARS-CoV-2 infection on the central nervous system

Research may lead to safer ways to care for patients impacted by blood clots

Research sheds light on how the cell selects suitable protein fragments for robust T-cell response

Obscure family of viruses already endemic in African monkeys "poised for spillover" to humans

The compositional and functional diversity of the gut fungal microbiome

SARS-CoV-2 spike protein and messenger ribonucleic acid found to translocate into the nucleus

Plasma proteome signature predictive of occurrence of persistent symptoms following SARS-CoV-2 infection

High-resolution pangenome dataset provides genetic insights into domestic and wild silkworm

What is the efficacy of curcumin as a photosensitizer, prophylactic and therapeutic agent against SARS-CoV-2?

Effectiveness of anti-SARS-CoV-2 immunoadhesin against omicron and other emerging variants

Oxytocin induces epicardial cell proliferation, study finds

Patients with scleroderma have reduced levels of Cathepsin L

Study reveals the role of autophagy in competitive elimination of cancer cells

Love hormone can activate heart repair mechanisms after cardiac injury, study finds

Bioactive compounds derived from Ganoderma lucidum exhibit anti-SARS-CoV-2 activity

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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