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Benefits of less intensive stem cell transplants for sickle cell disease

So-called low-intensity blood stem cell transplants, which use milder conditioning agents than standard stem cell transplants, do not appear to damage the lungs and may help improve lung function in some patients with sickle cell disease (SCD), according to a three-year study of adults who underwent the procedure at the National Institutes of Health (NIH).

28 Aug 2024

NIDDK Catalyst Award funds research on mammary gland's role in metabolic diseases

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Catalyst Award program has awarded a $4 million, five-year grant to Prashant Rajbhandari, PhD, Assistant Professor of Medicine (Endocrinology, Diabetes and Bone Disease) at the Mount Sinai Diabetes, Obesity, and Metabolism Institute, to investigate a new frontier in understanding metabolic diseases like obesity and type 2 diabetes.

27 Aug 2024

Austocystin D's anticancer efficacy linked to CYP2J2 enzyme activity

Austocystin D, a natural compound produced by fungi, has been recognized for its cytotoxic effects and anticancer activity in various cell types. It exhibits potent activity even in cells that express proteins associated with multidrug resistance, attracting significant global research interest.

27 Aug 2024

Research unveils how HMGA2 regulates stress responses in stem cells

Kumamoto University researchers have made a groundbreaking discovery that sheds light on how the HMGA2 gene - an essential transcriptional activator involved in chromatin modification - regulates stress responses in hematopoietic stem cells (HSCs), thereby enhancing blood cell production recovery.

22 Aug 2024

The role of soy in improving metabolic health

Pennington Biomedical Research Center's Dr. Candida Rebello wants to know more about the intersection of blood sugar levels and a diet rich in soy. This intersection is the primary focus of her new study, "Lifestyle Intervention for Improving Metabolic and Motivational Outcomes," or MOTIVATE, which explores how specific diets can impact blood sugar, and potentially improve mood and energy levels.

22 Aug 2024

Study finds potential for antidiabetic drugs to modify osteoarthritis risk

Whether antidiabetic medications could potentially be used as disease-modifying osteoarthritis drugs or DMOADs for the therapeutic management of osteoarthritis.

21 Aug 2024

$Gut microbiota linked to fracture risk: Study reveals key microbial associations$

Gut microbiota linked to fracture risk: Study reveals key microbial associations

The association between gut microbiota (GM) composition and incident fractures in the Finnish Risk Monitoring Program (FINRISK) 2002 cohort.

19 Aug 2024

Ribonucleic acid for injection II enhances immunity and hematopoiesis in immunosuppressed mice

Announcing a new publication for Acta Materia Medica journal. Ribonucleic acid for injection II is a clinical adjuvant cancer therapy treatment based on immunotherapy, which exerts its effects by enhancing immune function and suppressing tumor growth.

16 Aug 2024

Researchers reveal why a diet rich in magnesium is so important for your health

Researchers examined whether magnesium deficiency in the healthy middle-aged Australian population was independently or in combination with increased homocysteine levels associated with in vivo DNA damage.

15 Aug 2024

New research gives unprecedented view of colorectal cancer genetic makeup

Researchers provided a comprehensive genomic characterization of colorectal carcinoma, a type of cancer that starts in the colon or rectum, through whole-genome sequencing of 2,023 samples, identifying novel driver genes, molecular subgroups, and potential clinical implications.

15 Aug 2024

Study suggests mosquitoes as potential vectors for Buruli ulcers in Australia

Researchers find strong evidence suggesting mosquitoes may transmit Mycobacterium ulcerans, the bacteria causing Buruli ulcers, but caution that further study is needed.

15 Aug 2024

McGill discovery offers hope for targeted stem cell treatments

A new technique developed by McGill researchers for mechanically manipulating stem cells could lead to new stem cell treatments, which have yet to fulfill their therapeutic potential.

13 Aug 2024

Study reveals surge in e-scooter injuries in Denver and increased hospital admissions

The introduction of publicly shared electric scooters ("e-scooters") in Denver, Colorado has resulted in a steady increase in injuries and hospital admissions, according to research led by Alexander Lauder, MD, an orthopedic surgeon at Denver Health Medical Center.

13 Aug 2024

New genomic predictors of relapse in childhood B-cell acute lymphoblastic leukemia uncovered

Scientists from St. Jude Children's Research Hospital, Seattle Children's and the Children's Oncology Group (COG) have identified novel genetic variations that influence relapse risk in children with standard risk B-cell acute lymphoblastic leukemia (SR B-ALL), the most common childhood cancer.

12 Aug 2024

Advanced MRI scans could predict persistent symptoms in concussion patients

Offering patients with concussion a type of brain scan known as diffusion tensor imaging MRI could help identify the one in three people who will experience persistent symptoms that can be life changing, say Cambridge researchers.

8 Aug 2024

$Poor physical function, not bone density, drives higher fracture risk in older women with type 2 diabetes$

Poor physical function, not bone density, drives higher fracture risk in older women with type 2 diabetes

Study indicates that older women with type 2 diabetes have a higher risk of fractures primarily due to impaired physical function rather than reduced bone density, despite stronger bone structure.

8 Aug 2024

Breakthrough discovery could boost stem-cell transplants by improving cell mobilization

A discovery by a three-member Albert Einstein College of Medicine research team may boost the effectiveness of stem-cell transplants, commonly used for patients with cancer, blood disorders, or autoimmune diseases caused by defective stem cells, which produce all the body's different blood cells.

8 Aug 2024

Many children with recurrent wheezing have "silent" lung infections, research reveals

Nearly a quarter of children with recurrent wheezing have "silent" lung infections that would be better treated with antiviral medications than commonly prescribed steroids that can carry lifelong side effects, new research from the University of Virginia School of Medicine reveals.

8 Aug 2024

Polycystic ovary syndrome linked to greater risk of disordered eating in women

Women with the common reproductive and metabolic condition polycystic ovary syndrome (PCOS) face a greater risk of developing bulimia, binge eating disorder and disordered eating, according to new research published in The Journal of Clinical Endocrinology & Metabolism.

8 Aug 2024

Short bursts of high-intensity training found effective for stroke survivors

One-minute, short bursts of high-intensity interval training for 19 minutes may be more effective for improving fitness among people six months or more after a stroke than traditional, 20-30 minutes of moderate-intensity exercise sessions, according to research published today in Stroke, the peer-reviewed scientific journal of the American Stroke Association, a division of the American Heart Association.

8 Aug 2024

Bone News and Research

Benefits of less intensive stem cell transplants for sickle cell disease

NIDDK Catalyst Award funds research on mammary gland's role in metabolic diseases

Austocystin D's anticancer efficacy linked to CYP2J2 enzyme activity

Research unveils how HMGA2 regulates stress responses in stem cells

The role of soy in improving metabolic health

Study finds potential for antidiabetic drugs to modify osteoarthritis risk

Gut microbiota linked to fracture risk: Study reveals key microbial associations

Ribonucleic acid for injection II enhances immunity and hematopoiesis in immunosuppressed mice

Researchers reveal why a diet rich in magnesium is so important for your health

New research gives unprecedented view of colorectal cancer genetic makeup

Study suggests mosquitoes as potential vectors for Buruli ulcers in Australia

McGill discovery offers hope for targeted stem cell treatments

Study reveals surge in e-scooter injuries in Denver and increased hospital admissions

New genomic predictors of relapse in childhood B-cell acute lymphoblastic leukemia uncovered

Advanced MRI scans could predict persistent symptoms in concussion patients

Poor physical function, not bone density, drives higher fracture risk in older women with type 2 diabetes

Breakthrough discovery could boost stem-cell transplants by improving cell mobilization

Many children with recurrent wheezing have "silent" lung infections, research reveals

Polycystic ovary syndrome linked to greater risk of disordered eating in women

Short bursts of high-intensity training found effective for stroke survivors

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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