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Early exposure to inflammatory cytokines can paralyze CD4 T cells

In a discovery that is likely to rewrite immunology text books, researchers at UC Davis have found that early exposure to inflammatory cytokines, such as interleukin 2, can "paralyze" CD4 T cells, immune components that help orchestrate the body's response to pathogens and other invaders.

19 Aug 2015

PHIV children may lack immunity against measles, mumps, and rubella despite vaccination

Between one-third and one-half of individuals in the United States who were infected with HIV around the time of birth may not have sufficient immunity to ward off measles, mumps, and rubella--even though they may have been vaccinated against these diseases.

14 Aug 2015

Researchers create new cell screening method for immunotherapy cancer treatments

Researchers have created a new method for screening cells used in immunotherapy cancer treatments, allowing high-performing immune system cells to be studied in isolation and potentially expanding the number of patients for whom the breakthrough treatment proves successful.

11 Aug 2015

University of Liverpool study finds that HIV can continue to grow in patients despite treatment

HIV can continue to grow in patients who are thought to be responding well to treatment, according to research by the University of Liverpool.

5 Aug 2015

Research: Critical aspects of human genome's regulatory program encoded by genomic sequence elements

Since the classical studies of Jacob and Monod in the early 1960s, it has been evident that genome sequences contain not only blueprints for genes and the proteins that they encode, but also the instructions for a coordinated regulatory program that governs when, where and to what extent these genes and proteins are expressed.

4 Aug 2015

Researchers uncover master regulators that govern the fate of TFH cells

Follicular helper Tcells (TFH cells), a rare type of immune cell that is essential for inducing a strong and lasting antibody response to viruses and other microbes, have garnered intense interest in recent years but the molecular signals that drive their differentiation had remained unclear.

31 Jul 2015

amfAR releases recommendations to help U.S. states to achieve goals of National HIV/AIDS Strategy

Major achievements have been made in the domestic HIV/AIDS response as a result of increased realignment and coordination of efforts at the federal level. However, that level of consistent coordination and alignment has yet to take place in most states. In an effort to identify what needs to be done, amfAR, The Foundation for AIDS Research, in collaboration with the National HIV/AIDS Initiative at the O'Neill Institute for National and Global Health Law at Georgetown Law, has released a set of recommendations for how states across the U.S. can improve HIV prevention and care outcomes in an effort to achieve the goals identified within the National HIV/AIDS Strategy.

31 Jul 2015

Leishmania-fighting immune cells that linger after initial infections help ward off secondary attack

Immune cells that hang around after parasitic skin infection help ward off secondary attack, according to a study in The Journal of Experimental Medicine. These skin squatters may prove to be the key to successful anti-parasite vaccines.

28 Jul 2015

EGPAF calls for prioritizing HIV treatment among children

As the HIV/AIDS community gathers for the International AIDS Society Conference in Vancouver, Canada, the Elizabeth Glaser Pediatric AIDS Foundation joins the Vancouver Consensus in calling for universal treatment for all people living with HIV, regardless of CD4 count. Providing treatment for everyone living with HIV will be a paradigm shift in HIV treatment and prevention efforts, particularly for children living with HIV, and will save millions of lives.

22 Jul 2015

InnaVirVax presents positive results of IVVAC-3S/P1 study at International AIDS Society Conference

InnaVirVax, a biopharmaceutical company specialized in research and development of therapeutic and diagnostic solutions for major infectious and chronic diseases, today announced the overall results of its Phase I/IIa clinical study of its VAC-3S immunotherapy, which is currently in development.

22 Jul 2015

Early antiretroviral treatment prevents AIDS- and non-AIDS-related diseases in HIV-infected people

Starting antiretroviral therapy early not only prevents serious AIDS-related diseases, but also prevents the onset of cancer, cardiovascular disease, and other non-AIDS-related diseases in HIV-infected people, according to a new analysis of data from the Strategic Timing of AntiRetroviral Treatment (START) study, the first large-scale randomized clinical trial to establish that earlier antiretroviral treatment benefits all HIV-infected individuals.

22 Jul 2015

Beckman Coulter announces expansion of Cellular Accessible Retroviral Evaluation Systems Initiative at International AIDS Society 2015

Beckman Coulter Life Sciences today announces an expansion of its CARES Initiative at the 2015 International AIDS Society (IAS) Conference.

From Beckman Coulter Life Sciences - Flow Cytometry 21 Jul 2015

Researchers discover role of RORC mutations in patients with candidiasis and mycobacteriosis

The discovery of bi-allelic mutations in RORC in patients with candidiasis and mycobacteriosis revealed the pivotal role of RORC in mucocutaneous immunity to Candida and in systemic immunity to Mycobacterium in humans.

13 Jul 2015

Starting anti-HIV treatment early improves survival among patients with newly diagnosed TB

Starting anti-HIV treatment within two weeks of the diagnosis of tuberculosis, or TB, improved survival among patients with both infections who had very low immune-cell counts, according to an analysis by researchers at the University of Pittsburgh Graduate School of Health.

10 Jul 2015

Exhausted army of immune cells may damage the very body they are supposed to protect

An 'exhausted' army of immune cells may not be able to fight off infection, but if its soldiers fight too hard they risk damaging the very body they are meant to be protecting, suggests new research from the University of Cambridge.

30 Jun 2015

Study could point the way to new treatments for people with severe asthma

The immune response that occurs in patients with severe asthma is markedly different than what occurs in milder forms of the lung condition, according to researchers from the University of Pittsburgh School of Medicine. Those unique features could point the way to new treatments, they said in an article published online today in the Journal of Clinical Investigation.

30 Jun 2015

Sequence of immunizations could be the promising route to HIV vaccine

The secret to preventing HIV infection lies within the human immune system, but the more-than-25-year search has so far failed to yield a vaccine capable of training the body to neutralize the ever-changing virus. New research from The Rockefeller University, and collaborating institutions, suggests no single shot will ever do the trick. Instead, the scientists find, a sequence of immunizations might be the most promising route to an HIV vaccine.

19 Jun 2015

Single difference in HIV's genetic code influences progression of disease

In a finding that furthers the understanding of human immunodeficiency virus (HIV), researchers from Children's Hospital Los Angeles discovered two locations where a single difference in HIV's genetic code altered the way the virus infected the cell, thereby influencing the progression of the disease.

18 Jun 2015

Researchers examine proteins on surface of naive CD4+ T cells

The team headed by Dr. Kathrin Suttner, who, together with Prof. Dr. Carsten Schmidt-Weber, heads the airway immunology research group at the Helmholtz Zentrum München and Technische Universität München, concentrated its work on the so-called naive CD4+ T cells.

15 Jun 2015

PQBP1 protein could improve body's immune response to HIV vaccines

In a scientific discovery that has significant implications for preventing HIV infections, researchers at Sanford-Burnham Medical Research Institute have identified a protein that could improve the body's immune response to HIV vaccines and prevent transmission of the virus.

5 Jun 2015

CD4 News and Research

Early exposure to inflammatory cytokines can paralyze CD4 T cells

PHIV children may lack immunity against measles, mumps, and rubella despite vaccination

Researchers create new cell screening method for immunotherapy cancer treatments

University of Liverpool study finds that HIV can continue to grow in patients despite treatment

Research: Critical aspects of human genome's regulatory program encoded by genomic sequence elements

Researchers uncover master regulators that govern the fate of TFH cells

amfAR releases recommendations to help U.S. states to achieve goals of National HIV/AIDS Strategy

Leishmania-fighting immune cells that linger after initial infections help ward off secondary attack

EGPAF calls for prioritizing HIV treatment among children

InnaVirVax presents positive results of IVVAC-3S/P1 study at International AIDS Society Conference

Early antiretroviral treatment prevents AIDS- and non-AIDS-related diseases in HIV-infected people

Beckman Coulter announces expansion of Cellular Accessible Retroviral Evaluation Systems Initiative at International AIDS Society 2015

Researchers discover role of RORC mutations in patients with candidiasis and mycobacteriosis

Starting anti-HIV treatment early improves survival among patients with newly diagnosed TB

Exhausted army of immune cells may damage the very body they are supposed to protect

Study could point the way to new treatments for people with severe asthma

Sequence of immunizations could be the promising route to HIV vaccine

Single difference in HIV's genetic code influences progression of disease

Researchers examine proteins on surface of naive CD4+ T cells

PQBP1 protein could improve body's immune response to HIV vaccines

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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