CD4 News and Research

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Advancing towards 100% effective herpes vaccine

Genital herpes, caused by the herpes simplex virus 2 (HSV-2) is a very common sexually transmitted infection (STI). It affects 14% of Americans aged 15-49 years. There is no herpes vaccine at present. Many failed attempts at vaccine production have centered around HSV proteins.

23 Sep 2019

Editing away cancer and HIV in China: win or lose?

Scientists in China recently edited out the CCR5 gene from a patient with HIV's stem cells, but the research has sparked ethical debate.

13 Sep 2019

Texas Biomed researchers pinpoint important mechanism behind TB/HIV co-infection

Tuberculosis and HIV - two of the world's deadliest infectious diseases - are far worse when they occur together. Now, Texas Biomedical Research Institute researchers have pinpointed an important mechanism at work in this troubling health problem.

13 Sep 2019

Discovery may help identify signs of type 1 diabetes earlier

A new study showed that there are significant differences in the MHC class II antigens on the insulin peptide that is deficient in type 1 diabetes mellitus (T1DM). These determine the response of the T cells to the insulin peptide that causes destruction of insulin.

2 Sep 2019

New discovery may help identify type 1 diabetes earlier than is currently possible

Type 1 diabetes, an autoimmune disease that typically emerges before the age of 20, wipes out the body's ability to produce insulin--a hormone that's essential to life. Diagnosis often comes after symptoms arise, at which point the disease has taken hold.

30 Aug 2019

Novel immunotherapy method could overcome tumor immunity

Cancer immunotherapy is a form of treatment in which the body’s own immune cells are recruited to overcome the tumor. However, it is only useful in a few tumors, because of tumor immunity where tumor-associated immune cells work to protect the tumor against attack.

28 Aug 2019

Meat allergy triggered by tick bites explained

Researchers from University of Virginia School of Medicine have uncovered the mystery behind development of allergic reactions to red meat such as beef in some individuals. Recently there has been a body of research on allergies to meat developing in individuals due to tick bites.

21 Aug 2019

Roswell Park receives more than $15 million in grants for cancer research

Roswell Park Comprehensive Cancer Center researchers have received more than a dozen recent grant awards totaling more than $15.4 million.

14 Aug 2019

Research seeks to fight organ rejection in kidney transplant patients

While waiting on the transplant list, most patients are extremely sick and fighting just to stay alive.

1 Aug 2019

Researchers explore how HIV spreads in 3D tissue-like environments

The spread of pathogens like the human immunodeficiency virus (HIV) is often studied in a test tube, i.e. in two-dimensional cell cultures, even though it hardly reflects the much more complex conditions in the human body.

25 Jul 2019

New vaccine shows promise against toughest HIV strains

A new study reports successful immunization against a so-far invincible “death star” strain of an HIV-related laboratory virus (SIVmac239) and another tough strain. The new approach also achieves long-term protection with a single dose, showing that gene therapy could allow broad and durable protection, based on a modified form of the CD4 protein that allows HIV entry into human cells.

24 Jul 2019

Researchers identify encephalitis as rare toxicity of immunotherapy treatment

After a cancer patient receiving an immunotherapy developed encephalitis and died 18 months into treatment, researchers at Vanderbilt-Ingram Cancer Center investigated why the complication occurred, performing a molecular analysis of the disease's pathology and mining data to determine the incidence of similar occurrences.

22 Jul 2019

Study reveals how aggressive prostate cancer metastasizes by evading the immune system

Researchers at The University of Texas MD Anderson Cancer Center have discovered how an aggressive form of prostate cancer called double-negative prostate cancer (DNPC) metastasizes by evading the the immune system.

18 Jul 2019

HIV therapy leaves unrepaired holes in the immune system's wall of defense

If they don't receive antiretroviral therapy (ART), most HIV patients see a progressive weakening of their immune system.

16 Jul 2019

Patients with HIV DNA in cerebrospinal fluid have high risk of experiencing cognitive deficits

Investigators from the AIDS Clinical Trials Group, the world's largest and longest-established HIV research network, today announced that the Journal of Clinical Investigation published new findings from the ACTG HIV Reservoirs Cohort Study.

16 Jul 2019

WHO's 'Treat All' HIV recommendation widely adopted globally

Faced with a global epidemic of HIV, the World Health Organization advised back in 2015 that a new health policy, summed up as “Treat All”, be adopted in all health facilities around the world that deal with HIV patients.

16 Jul 2019

Reprogramming cells to control HIV infection

Cells from the rare individuals who naturally control HIV infection have been the focus of investigation for nearly 15 years with the aim of elucidating their specific features.

14 Jul 2019

Researchers discover new immune cells that are at the frontline of HIV infection

Researchers at The Westmead Institute for Medical Research have discovered brand new immune cells that are at the frontline of HIV infection. Known as CD11c+ dendritic cells, these new cells are more susceptible to HIV infection and can then transmit the virus to other cells.

24 Jun 2019

Most preferred drug for HIV may not be as safe as suggested

A study lead by researchers at the Institute of HIV Research, Medical Faculty of UDE and University Hospital Essen, stumbled over a potential toxicity of integrase inhibitors.

21 Jun 2019

Researchers find more effective way to treat drug-resistant cancers

Researchers at SMU's Center for Drug Discovery, Design and Delivery have succeeded in lab testing the use of chemotherapy with a specific protein inhibitor so that the chemotherapeutic is better absorbed by drug-resistant cancer cells without harming healthy cells.

10 Jun 2019