Neurological Disease News and Research

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PGC-1 alpha implicated in Huntington's disease neurodegeneration

A metabolic disorder underlies the brain effects found in those with Huntington's disease, researchers report in an advance article publishing online October 19, 2006. The article will appear in the November 2006 issue of the journal Cell Metabolism, published by Cell Press.

20 Oct 2006

Licensing arrangement reached for antiepileptic drug developed at Hebrew University

A worldwide licensing arrangement for development, production and marketing of an antiepileptic drug created at the Hebrew University of Jerusalem has been signed by Shire Pharmaceuticals with Yissum, the Hebrew University's technology transfer company.

5 Sep 2006

Boosting enzyme may reverse Alzheimer's

New research by scientists at Columbia University suggests that boosting the function of a certain enzyme may provide a promising strategy for battling Alzheimer's disease, and possibly reversing its effects.

28 Aug 2006

Evidence of a genetic risk factor for Parkinson's disease

A Mayo Clinic-led international research collaboration - one of the largest studies of its kind - provides strong evidence that a genetic risk factor may account for 3 percent of the cause of Parkinson's disease.

8 Aug 2006

For the first time, scientists watch neurons change in response to experience

Thanks to a new imaging system, researchers at MIT's Picower Institute for Learning and Memory have gotten an unprecedented look into how genes shape the brain in response to the environment.

6 Aug 2006

Pig cell implants show potential for treatment of stroke, Huntington's disease

A review of accumulated evidence on the use of porcine brain choroid plexus (CP) cells published in the July issue of Xenotransplantation highlights that these cells have the potential to treat acute and chronic brain disease.

24 Jul 2006

Ergonomic and physiotherapeutic interventions for treating work-related complaints of the arm, neck or shoulder in adults

Many conservative methods used to treat work-related complaints of the upper body have only limited effectiveness, according to an updated systematic review by Arianne Verhagen, Ph.D., and her colleagues in the Netherlands.

21 Jul 2006

Protein called Elk-1appears to play role in neurodegeneration and schizophrenia

Pprotein called Elk-1 interacts with mitochondria, the energy storehouse of a cell, suggesting that this protein - typically active in the nucleus - could play a role in cell death and mitochondria-related diseases such as neurodegeneration and schizophrenia.

9 Jun 2006

Search for gene search for sporadic amyotrophic lateral sclerosis

Though it's the more common form of the disease, sporadic Amyotrophic Lateral Sclerosis (ALS), which affects roughly 90 percent of those living with the fatal neurodegenerative illness, has been the one less studied, simply because, unlike familial ALS, no genes have turned up.

17 May 2006

Researchers link novel mutated gene to mental retardation and imbalance syndrome

Researchers at the University of California, San Diego School of Medicine have identified a genetic cause for a form of pediatric brain malformation involving the cerebellum.

11 May 2006

Interferon-gamma plays a critical role in damaging the cells that produce myelin

A new way to preserve the cells that surround and protect nerves could lead to new treatments for demyelinating diseases such a multiple sclerosis, a research team reports in the May 10, 2006, issue of the Journal of Neuroscience.

10 May 2006

Neurons can produce Alzheimer's-linked apolipoprotein E

A question long debated among Alzheimer's disease researchers has been definitively answered by scientists at the Gladstone Institute of Neurological Disease in San Francisco.

10 May 2006

Study shows drugs work differently in the brains of men and women

A Johns Hopkins discovery could lead to tailored treatments for drug abuse and neurological diseases after providing what is believed to be the first evidence in people that amphetamines have a greater effect on men's brains than women's.

24 Apr 2006

Mediterranean diet reduces risk of Alzheimer's disease

Americans who ate a Mediterranean diet--lots of fruits, vegetables, legumes, cereals, some fish and alcohol, and little dairy and meat--had a reduced risk for Alzheimer's disease as they aged. These findings are published in the April issue of Annals of Neurology.

18 Apr 2006

Mount Sinai launches CombiRx trial to treat relapsing-remitting Multiple Sclerosis

Mount Sinai School of Medicine is the Clinical Coordinating Center for the first study to assess the effectiveness of combining two FDA approved medications as initial treatment for people with Relapsing Remitting Multiple Sclerosis.

11 Apr 2006

Ceftriaxone may help fight dementia in HIV patients

An antibiotic commonly used to treat a variety of serious infections may also help prevent dementia in HIV patients, according to a test-tube study of human brain cells by Johns Hopkins University School of Medicine neurologist Jeffrey Rumbaugh, M.D., Ph.D.

7 Apr 2006