Protein C News and Research

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Prior infection with SARS-CoV-2 continues to provide protection from reinfection

Researchers from the University of Michigan investigated the correlation between SARS-CoV-2 infection and the severity of reinfections.

30 Nov 2021

Potentially neurotoxic SARS-CoV-2 protein fragments

Researchers investigate potentially amyloidogenic peptide fragments that could be associated with the neurological symptoms of COVID-19 and long-COVID.

30 Nov 2021

Host and in vitro genomic variability of SARS-CoV-2 and its variants

Researchers from the University of Sydney investigate the genomic variability of SARS-CoV-2 within the host and in vitro.

30 Nov 2021

Structure-guided virtual screening identifies novel SARS-CoV-2 Mpro inhibitors

A new paper deals with the identification of an antiviral compound that could help in developing additional drugs to help fight COVID-19.

30 Nov 2021

Anti-SARS-CoV-2 antibodies suggested to be safe to use in pregnancy

Pregnant patients with mild to moderate COVID-19 were treated with MAb and reported no adverse effects.

30 Nov 2021

Study uncovers new mechanism to explain how obesity jeopardizes the functions of skeletal muscle

A decline in metabolism and endurance of skeletal muscle is commonly observed in obese patients, but the underlying mechanism is not well-understood.

30 Nov 2021

Human LRRC15 protein is an inhibitory receptor for SARS-CoV-2 spike-mediated entry

In a recent study, published on the bioRxiv* preprint server, researchers identified human LRRC15 as an inhibitory receptor for SARS-CoV-2 entry, which directly binds to the receptor-binding domain (RBD) of the spike protein with a moderate affinity and inhibits spike-mediated entry.

29 Nov 2021

SARS-CoV-2 Delta spike increases viral virulence and inflammatory cytokine production

In a new study published on the bioRxiv* preprint server, scientists investigated several virological features of the Delta spike protein.

29 Nov 2021

Targeted measures to prevent the spread of Omicron variant take effect from 30 November 2021

Targeted measures to prevent the spread of the new COVID-19 Omicron variant take effect from 4am today [Tuesday 30 November].

29 Nov 2021

New phenotype of LRP6 mutation reported for the first time in patients with tooth agenesis

A group led by Prof. Han Dong of Peking University School of Stomatology reported for the first time hand preaxial polydactyly in patients with tooth agenesis carrying a previously unknown mutation of low-density lipoprotein receptor-related protein 6 (LRP6).

29 Nov 2021

The mode of action of essential proteins involved in cancer and Alzheimer´s deciphered

The proteins that belong to the HAT family are essential for life as they transport amino acids across the cell membrane. Although the members of this family are practically identical, some transport certain amino acids and not others.

29 Nov 2021

Rare variants in high-risk autism gene can alter architecture and organization of neurons, study finds

Scientists at the University of North Carolina at Chapel Hill School of Medicine and colleagues have demonstrated that rare variants in the ANK2 gene, consistently found in individuals with autism spectrum disorder (ASD), can alter architecture and organization of neurons, potentially contributing to autism and neurodevelopmental comorbidities.

29 Nov 2021

Biologists discover how a protein in our body works

It's an old needlework trick, and a protein in our body knows it: Instead of threading yarn into the eye from the end, it can be easier to pass a loop through it.

29 Nov 2021

Novel influenza vaccine candidate shows promise

Researchers investigate the potential value of a new vaccine candidate for the influenza virus.

29 Nov 2021

Genetic variations affect and rewire phosphorylation signaling networks in SARS-CoV-2 infection

Researchers study human single nucleotide variants (SNVs) using machine learning to identify amino acid changes that alter kinase-bound sequence motifs.

29 Nov 2021

Circulating microbubbles for measuring oxygen levels

Blood carries vital oxygen through our circulation system to muscles and organs. Acoustic tools can create small bubbles in our blood, capable of changing in response to oxygen and signifying oxygen levels.

29 Nov 2021

Glycosylation and disulfide bonding profile of SARS-CoV-2 spike glycoprotein

Researchers found that virus-like particles produced by co-expression of SARS-CoV-2 S, membrane, envelope, and nucleocapsid proteins contain S glycoproteins, which are modified by complex carbohydrates.

29 Nov 2021

Extended host range for SARS-CoV-2 variants of concern

Researchers used viral pseudotyping to examine whether variants of concern had different host ACE2 receptor usage patterns.

29 Nov 2021

Tomosyn protein's key contribution to heterogeneity of neurons revealed

The versatility of the nervous system comes from not only the diversity of ways in which neurons communicate in circuits, but also their "plasticity," or ability to change those connections when new information has to be remembered, when their circuit partners change, or other conditions emerge.

29 Nov 2021

Study uncovers mechanism for insensitivity to key antimalarial drug in new pathogen variant

Malaria is one of the most dangerous infectious diseases. The causative pathogens are microorganisms of the genus Plasmodium.

29 Nov 2021

Protein C News and Research

Prior infection with SARS-CoV-2 continues to provide protection from reinfection

Potentially neurotoxic SARS-CoV-2 protein fragments

Host and in vitro genomic variability of SARS-CoV-2 and its variants

Structure-guided virtual screening identifies novel SARS-CoV-2 Mpro inhibitors

Anti-SARS-CoV-2 antibodies suggested to be safe to use in pregnancy

Study uncovers new mechanism to explain how obesity jeopardizes the functions of skeletal muscle

Human LRRC15 protein is an inhibitory receptor for SARS-CoV-2 spike-mediated entry

SARS-CoV-2 Delta spike increases viral virulence and inflammatory cytokine production

Targeted measures to prevent the spread of Omicron variant take effect from 30 November 2021

New phenotype of LRP6 mutation reported for the first time in patients with tooth agenesis

The mode of action of essential proteins involved in cancer and Alzheimer´s deciphered

Rare variants in high-risk autism gene can alter architecture and organization of neurons, study finds

Biologists discover how a protein in our body works

Novel influenza vaccine candidate shows promise

Genetic variations affect and rewire phosphorylation signaling networks in SARS-CoV-2 infection

Circulating microbubbles for measuring oxygen levels

Glycosylation and disulfide bonding profile of SARS-CoV-2 spike glycoprotein

Extended host range for SARS-CoV-2 variants of concern

Tomosyn protein's key contribution to heterogeneity of neurons revealed

Study uncovers mechanism for insensitivity to key antimalarial drug in new pathogen variant

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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