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UPMC expert finds successful treatment for rare diseases diagnosed by newborn screenings

1It was a nagging mystery: A rare-disease expert at UPMC Children's Hospital of Pittsburgh had found a successful treatment for two of the deadliest symptoms of one of the more common classes of rare diseases diagnosed by newborn screenings, but one symptom--painful episodes of muscle breakdown that land victims in intensive care--persisted.

29 Jun 2021

Patient-psychotherapist matching improves outcomes of mental health treatment

In first-of-its kind research led by a University of Massachusetts Amherst psychotherapy researcher, mental health care patients matched with therapists who had a strong track record of treating the patients' primary concerns had better results than patients who were not so matched.

29 Jun 2021

What's behind COVID-19 vaccine side effects?

A growing concern among coronavirus vaccines is the vaccine side effects. Fear or misinformation about side effects may fuel vaccine hesitancy, contributing to low vaccination rates. Australian researchers recently published an article in Science Immunology to discuss why people develop side effects and their benefits.

28 Jun 2021

Review: Endovascular therapy is the safest, most effective treatment for superior vena cava syndrome

Like a blocked water line, obstructions in blood vessels in the human circulatory system can cause serious problems.

28 Jun 2021

Novel approach to molecular drug design paves way for promising bladder cancer therapy

A new approach to molecular drug design has yielded a highly promising bladder cancer drug, which induced rapid shedding of tumor cells and resulted in a significant reduction in tumour size when used in clinical trials.

28 Jun 2021

Preliminary results of AAV-mediated gene therapy for Crigler Najjar syndrome

Preliminary results from the European gene therapy trial for Crigler-Najjar syndrome, conducted by Genethon in collaboration with European network CureCN, were presented at the EASL (European Association for the Study of the Liver) annual International Liver Congress on June 26.

28 Jun 2021

Alzheimer's symptoms could be due to decline in brain protein not accumulation of amyloid plaques

Experts estimate more than 6 million Americans are living with Alzheimer's dementia. But a recent study, led by the University of Cincinnati, sheds new light on the disease and a highly debated new drug therapy.

28 Jun 2021

Sunflower peptide identified as a potential drug for treating abdominal pain

A naturally occurring peptide in sunflower seeds was synthetically optimised and has now been identified as a potential drug for treating abdominal pain or inflammation (in the gastrointestinal tract, abdominal area and/or internal organs).

28 Jun 2021

Moffitt awarded $10.2 million grant to investigate lung cancer metabolism

The National Cancer Institute has awarded the Lung Cancer Metabolism Working Group at Moffitt Cancer Center with a Research Program Project Grant (P01CA250984).

28 Jun 2021

Virtual reality can help boost brain rhythms linked to learning and memory

A new discovery in rats shows that the brain responds differently in immersive virtual reality environments versus the real world.

28 Jun 2021

Blood cancer patients show widely variable response to COVID-19 vaccines

Patients with a type of blood cancer called multiple myeloma had a widely variable response to COVID-19 vaccines--in some cases, no detectable response--pointing to the need for antibody testing and precautions for these patients after vaccination, according to a study that will be published in Cancer Cell this week.

28 Jun 2021

People living with HIV/AIDS more likely to have suicidal thoughts and die from suicide

A new study by researchers at Penn State College of Medicine indicates that people living with human immunodeficiency virus (HIV) and acquired immune deficiency syndrome (AIDS) - approximately 38 million worldwide - are more likely to have suicidal thoughts and die from suicide than members of the general population.

28 Jun 2021

New analysis links distinct patterns of genetic mutations with OCD

In the first analysis of its kind, researchers at Columbia University Vagelos College of Physicians and Surgeons and several other institutions have linked distinct patterns of genetic mutations with obsessive-compulsive disorder (OCD) in humans.

28 Jun 2021

Study examines effect of sorafenib in patients with advanced hepatocellular carcinoma

Oncotarget published "Insulin-like growth factor 1/Child-Turcotte-Pugh composite score as a predictor of treatment outcomes in patients with advanced hepatocellular carcinoma treated with sorafenib" which reported that this study investigated the association of the IGF/CTP score with overall survival and progression-free survival of HCC patients treated with sorafenib.

28 Jun 2021

Promising immunotherapy uses cancer-killing cells to destroy malignant tumors

Researchers at McMaster University have developed a promising new cancer immunotherapy that uses cancer-killing cells genetically engineered outside the body to find and destroy malignant tumors.

28 Jun 2021

Antagonism of glucocorticoid receptors promotes apoptosis in solid tumor cells

Oncotarget published "Glucocorticoid receptor antagonism promotes apoptosis in solid tumor cells" which reported that to guide studies in cancer patients, relacorilant, an investigational selective GR modulator that antagonizes cortisol activity, was assessed in various tumor types, with multiple cytotoxic combination partners, and in the presence of physiological cortisol concentrations.

28 Jun 2021

Tocilizumab and sarilumab shown to be effective in critical COVID-19

A new study, released as a preprint on the medRxiv* server, describes how a team of researchers from the University Medical Center Utrecht in the Netherlands explored the efficacy of four monoclonal antibodies that antagonize powerful pro-inflammatory pathways. The team sought to determine which were useful in treating critically ill COVID-19 patients on organ support.

28 Jun 2021

Why SARS-CoV-2 delta variant is more infectious

German experts recently explained why the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) delta variant is more infectious and pathogenic than its ancestor. By conducting a series of in vitro experiments, they have revealed that increased ability to induce cell-to-cell fusion (syncytia) and reduced susceptibility to vaccine and infection-induced antibodies make the delta variant more infectious than previously circulating variants. The study is currently available on the bioRxiv* preprint server.

28 Jun 2021

Researchers to test early intervention for caregivers of patients with serious illnesses or injuries

An early intervention developed for caregivers of patients with serious illnesses or injuries will be tested by researchers at The University of Texas Health Science Center at Houston.

25 Jun 2021

Muscles lose their smallest, most basic building blocks after stroke

After suffering a stroke, patients often are unable to use the arm on their affected side. Sometimes, they end up holding it close to their body, with the elbow flexed.

25 Jun 2021