Research News and Research

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Imatinib-related symptom burden linked to adherence in Indian CML patients

Research shows low adherence to imatinib in Indian patients with chronic myeloid leukaemia, with an association between nonadherence and worse symptom burden related to treatment.

21 Apr 2016

KEYNOTE-001 findings add support to pembrolizumab for advanced melanoma

A third of patients with advanced or metastatic melanoma will achieve an objective response to treatment with the programmed cell death protein inhibitor pembrolizumab, suggest KEYNOTE-001 findings, regardless of whether they have previously been treated with ipilimumab.

21 Apr 2016

Pre-TKI cytokine profiling predicts CP-CML outcome

Measuring levels of transforming growth factor-α and interleukin-6 may help identify patients with newly diagnosed chronic phase-chronic myeloid leukaemia at risk of a poor outcome from tyrosine kinase inhibitor therapy, research suggests.

20 Apr 2016

Additional chromosomal abnormalities prognostic for CML

Additional chromosomal abnormalities can be used to create two prognostic groups of patients with chronic myeloid leukaemia, suggests research published in Blood.

20 Apr 2016

Proteins can be used as targets to deliver drugs into stressed cancer cells

Targeted missiles that can enter cancer cells and deliver lethal cell toxins without harming surrounding healthy tissue. This has been a long-standing vision in cancer research, but it has proved difficult to accomplish. A research group at Lund University in Sweden has now taken some crucial steps in this direction.

20 Apr 2016

Researchers discover new, previously underappreciated role for immature dentate gyrus granule cells

University of Alabama at Birmingham researchers have proposed a model that resolves a seeming paradox in one of the most intriguing areas of the brain -- the dentate gyrus.

20 Apr 2016

Researchers develop insoles impregnated with silver nanoparticles to treat diabetic foot syndrome

Scientists from Tomsk Polytechnic University and National Autonomous Mexico University develop techniques to treat diabetic foot syndrome with special insoles with silver nano-particles. The techniques help to fight ulcers appearing on feet in diabetic patients, facilitates their healing and disinfection, reducing the risk of amputation.

20 Apr 2016

Scientists identify pSTS region in the brain responsible for recognizing human facial expressions

Researchers at The Ohio State University have pinpointed the area of the brain responsible for recognizing human facial expressions.

20 Apr 2016

Adding CYP24A1 inhibitors may improve antitumor activity of vitamin D

Roswell Park Cancer Institute research on the most potent form of vitamin D, commonly called calcitriol, offers new insights into approaches that may enhance the antitumor activity of this much-studied human hormone.

20 Apr 2016

Specific oral microbiome linked to pancreatic cancer risk

The presence of certain bacteria in the mouth may reveal increased risk for pancreatic cancer and enable earlier, more precise treatment. This is the main finding of a study led by researchers at NYU Langone Medical Center and its Laura and Isaac Perlmutter Cancer Center to be presented April 19 in New Orleans at the annual meeting of the American Association for Cancer Research.

20 Apr 2016

Hormonal contraception may increase susceptibility of women to genital infection

Women account for approximately half of all individuals living with HIV worldwide, and researchers wanted to identify the risk factors that increase susceptibility of women to genital infection.

20 Apr 2016

Scientists develop new drug for life-threatening lung disease treatment

Researchers are developing a new drug to treat life-threatening lung damage and breathing problems in people with severe infections like pneumonia, those undergoing certain cancer treatments and premature infants with underdeveloped, injury prone lungs.

20 Apr 2016

New mouse model to aid in development of antiviral compounds, vaccines against Zika virus

Researchers at the University of Wisconsin-Madison School of Veterinary Medicine have developed one of the first mouse models for the study of Zika virus. The model will allow researchers to better understand how the virus causes disease and aid in the development of antiviral compounds and vaccines.

20 Apr 2016

Study evaluates influence of midwife-led antenatal care on VBAC rates

Women who had a caesarean section in a previous pregnancy are much more likely to have a safer vaginal birth if their antenatal care is led by a midwife, according to a new study from The University of Manchester.

20 Apr 2016

New clinical study to evaluate inexpensive drug to prevent type 1 diabetes

A clinical study evaluating a new hypothesis that an inexpensive drug with a simple treatment regimen can prevent type 1 diabetes will be launched in Dundee tomorrow.

20 Apr 2016

New study suggests re-evaluation of long-held method to predict effectiveness of seasonal influenza vaccine

The long-held approach to predicting seasonal influenza vaccine effectiveness may need to be revisited, new research suggests. Currently, seasonal flu vaccines are designed to induce high levels of protective antibodies against hemagglutinin (HA), a protein found on the surface of the influenza virus that enables the virus to enter a human cell and initiate infection.

20 Apr 2016

Genetic markers may influence how breast cancer patients respond to treatment

Two previously unrecognized genetic markers may predict whether breast cancer patients would benefit from chemotherapy followed by tamoxifen, according to preclinical research from Roswell Park Cancer Institute, in collaboration with the cooperative research group SWOG and St. Jude Children's Research Hospital. The results of this research will be presented at the American Association for Cancer Research Annual Meeting 2016, to be held April 16-20 in New Orleans.

20 Apr 2016

Immunotherapy drug pembrolizumab shrinks tumors in patients with Merkel cell carcinoma

In a clinical trial of the immunotherapy drug pembrolizumab, half of 25 patients with a rare type of virus-linked skin cancer called Merkel cell carcinoma experienced substantial tumor shrinkage lasting nearly three times as long, on average, than with conventional chemotherapy.

20 Apr 2016

Nivolumab drug shows survival benefit in phase III trial of patients with head and neck cancer

The immunotherapy drug nivolumab has become the first to show a survival benefit in head and neck cancer, after a major international trial found that it was more effective than standard chemotherapy.

20 Apr 2016

DKFZ researchers develop new methods to study disease-relevant changes in production of oxidants

There are many false beliefs and myths about the role of oxidants and antioxidants in the human body. Traditionally, oxidants are presented as harmful and antioxidants as health-promoting. However, scientists have known for many years that endogenous oxidants are essential chemical messengers that help keep up the functions of the organism.

20 Apr 2016

Research News and Research

Imatinib-related symptom burden linked to adherence in Indian CML patients

KEYNOTE-001 findings add support to pembrolizumab for advanced melanoma

Pre-TKI cytokine profiling predicts CP-CML outcome

Additional chromosomal abnormalities prognostic for CML

Proteins can be used as targets to deliver drugs into stressed cancer cells

Researchers discover new, previously underappreciated role for immature dentate gyrus granule cells

Researchers develop insoles impregnated with silver nanoparticles to treat diabetic foot syndrome

Scientists identify pSTS region in the brain responsible for recognizing human facial expressions

Adding CYP24A1 inhibitors may improve antitumor activity of vitamin D

Specific oral microbiome linked to pancreatic cancer risk

Hormonal contraception may increase susceptibility of women to genital infection

Scientists develop new drug for life-threatening lung disease treatment

New mouse model to aid in development of antiviral compounds, vaccines against Zika virus

Study evaluates influence of midwife-led antenatal care on VBAC rates

New clinical study to evaluate inexpensive drug to prevent type 1 diabetes

New study suggests re-evaluation of long-held method to predict effectiveness of seasonal influenza vaccine

Genetic markers may influence how breast cancer patients respond to treatment

Immunotherapy drug pembrolizumab shrinks tumors in patients with Merkel cell carcinoma

Nivolumab drug shows survival benefit in phase III trial of patients with head and neck cancer

DKFZ researchers develop new methods to study disease-relevant changes in production of oxidants

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