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UAB lab to offer new tests for genetic diseases using next-generation sequencing

The Medical Genomics Laboratory at the University of Alabama at Birmingham is expanding its technological array with a new panel of diagnostic tests for genetic diseases known as neurofibromatoses and rasopathies. Beginning April 18, the UAB lab will offer new tests using the technique called customized deep-coverage, next-generation sequencing or NGS.

18 Apr 2016

Existing cancer drugs may be able to help people with enlarged heart cells

UT Southwestern Medical Center cardiology researchers have identified molecular ties between the growth of cancer cells and heart cells that suggest existing cancer drugs may be able to help those with enlarged heart cells -- a condition that can lead to heart attacks and stroke.

18 Apr 2016

Researchers determine mutations in RERE gene can cause many features linked with 1p36 deletions

One in 5,000 babies is born missing a small amount of genetic material from the tip of chromosome 1, a region called 1p36. Missing genes in the 1p36 region is a relatively common cause of intellectual disability.

18 Apr 2016

Professor outlines effects of sports-specific counseling on injury outcomes in youth athletes

Neeru Jayanthi, MD, Associate Professor of Orthopedics and Sports Medicine at Emory University Sports Medicine Center in Atlanta, GA, presented "The Effects of Serial Sports Training Risk Assessment and Counseling in Kids (T.R.A.C.K.)" at the 25th Annual Meeting of the American Medical Society for Sports Medicine in Dallas, TX.

18 Apr 2016

Medi-551 antibody treatment decreases number of cancer stem cells by half in multiple myeloma patients

An experimental antibody treatment decreased by half the number of cancer stem cells that drive the growth of tumors in nearly all patients with multiple myeloma, a cancer of the bone marrow and bone tissue, according to results of a preliminary clinical trial led by Johns Hopkins Kimmel Cancer Center scientists.

18 Apr 2016

False-positive mammogram results may have varied effects on subsequent screening behavior of women

Depending on when they received their last mammogram, women who receive a false-positive result are more or less likely to get screened at recommended intervals, according to preliminary findings from a University of North Carolina Comprehensive Cancer Center study.

18 Apr 2016

First-ever nivolumab drug trial for rare, malignant SCCA shows positive results

A rare malignancy known as squamous cell carcinoma of the anal canal (SCCA) is on the increase, and now researchers have reported results of the first-ever phase II clinical trial results for treatment with the immunotherapy drug nivolumab.

18 Apr 2016

Research finds high prevalence of smoking, low cessation rates in people with schizophrenia

Smoking addiction in schizophrenia can be explained by significantly increased activation of the ventro-medial prefrontal cortex (vmPFC), a region involved in the brain reward system. These new data, the result of a study by researchers at the Institut universitaire en santé mentale de Montréal and the University of Montreal confirms the tendency to smoke and low smoking cessation rates of people with schizophrenia.

18 Apr 2016

LOXO-101 drug shows efficacy with tumor regression in varied types of genetically defined cancer

A phase I study of the drug LOXO-101 appears to significantly reduce tumors in patients with varied types of genetically defined cancer, according to a study led by The University of Texas MD Anderson Cancer Center.

18 Apr 2016

Mouse model can help identify new, more effective melanoma-preventing agents

Application of sun protection factor 30 (SPF30) sunscreen prior to exposure to ultraviolet-B (UVB) light delayed melanoma onset in a mouse model of the disease, according to data from a team at The Ohio State University Comprehensive Cancer Center Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute. This data suggest that the mouse model can be used to identify new, more effective melanoma-preventing agents, according to principal investigator Christin Burd, PhD.

18 Apr 2016

Scientists develop innovative technique to deliver cancer drugs deep into tumour cells

Scientists at Nanyang Technological University (NTU Singapore) have invented a new way to deliver cancer drugs deep into tumour cells.

18 Apr 2016

Green vegetation near homes plays important role in reducing mortality

Women live longer in areas with more green vegetation, according to new research funded by the National Institute of Environmental Health Sciences (NIEHS), part of the National Institutes of Health. Women with the highest levels of vegetation, or greenness, near their homes had a 12 percent lower death rate compared to women with the lowest levels of vegetation near their homes. The results were published Apr. 14, 2016 in the journal Environmental Health Perspectives.

18 Apr 2016

South Dakota researchers aim to improve tobacco-free policies in health-care facilities

Health-care facilities being tobacco-free seems like a natural fit, but it's far more complicated than it might seem.

18 Apr 2016

Study shows safety of experimental drug guadecitabine in colorectal cancer patients

In a small, phase I clinical trial, Johns Hopkins Kimmel Cancer Center researchers say they show for the first time that the experimental drug guadecitabine (SGI-110) is safe in combination with the chemotherapy drug irinotecan and may overcome resistance to irinotecan in patients with metastatic colorectal cancer.

18 Apr 2016

Survivin inhibitor with chemotherapy provides therapeutic advantage for Rb cells, tumors

Researchers at The Saban Research Institute of Children's Hospital Los Angeles (CHLA) have demonstrated that targeting survivin - a protein that inhibits apoptosis or cell death - enhances the effectiveness of chemotherapy in cells and mouse models of retinoblastoma (Rb), the most common malignant tumor of the eye in children.

18 Apr 2016

Scientists develop graphene-based sensor that can detect harmful air pollution in home

Scientists from the University of Southampton, in partnership with the Japan Advanced Institute of Science and Technology, have developed a graphene-based sensor and switch that can detect harmful air pollution in the home with very low power consumption.

18 Apr 2016

Computer-based cognitive remediation at home can improve cognitive symptoms in MS patients

Cognitive impairment is one of the core symptoms of multiple sclerosis (MS) -- and one of its most troubling concerns for many people with the condition. Now, a new study from NYU Langone Medical Center may provide hope for symptomatic relief for some of the cognitive issues associated with the neurological disease.

18 Apr 2016

MGH-led study confirms safety of allergy immunotherapy

A team of Massachusetts General Hospital investigators has found no evidence of infections related to administration of allergy immunotherapy, the common practice of injecting minimal quantities of allergens beneath the skin to reduce the allergic response.

18 Apr 2016

Study indicates mRS is poorly suited to evaluate, report quality of neuro-surgery

Surgery has become a volatile field during the past few years, with study after study challenging prevailing treatment practices. For example, surgical treatment of acute appendicitis and arthroscopic surgery on degenerative knees have been called into question by recent research results reached by Finnish researchers.

18 Apr 2016

Developing countries face health financing crisis due to low domestic investment, stagnating international aid

Two major studies published in The Lancet reveal the health financing crisis facing developing countries as a result of low domestic investment and stagnating international aid, which could leave millions of people without access to even the most basic health services.

18 Apr 2016

Research News and Research

UAB lab to offer new tests for genetic diseases using next-generation sequencing

Existing cancer drugs may be able to help people with enlarged heart cells

Researchers determine mutations in RERE gene can cause many features linked with 1p36 deletions

Professor outlines effects of sports-specific counseling on injury outcomes in youth athletes

Medi-551 antibody treatment decreases number of cancer stem cells by half in multiple myeloma patients

False-positive mammogram results may have varied effects on subsequent screening behavior of women

First-ever nivolumab drug trial for rare, malignant SCCA shows positive results

Research finds high prevalence of smoking, low cessation rates in people with schizophrenia

LOXO-101 drug shows efficacy with tumor regression in varied types of genetically defined cancer

Mouse model can help identify new, more effective melanoma-preventing agents

Scientists develop innovative technique to deliver cancer drugs deep into tumour cells

Green vegetation near homes plays important role in reducing mortality

South Dakota researchers aim to improve tobacco-free policies in health-care facilities

Study shows safety of experimental drug guadecitabine in colorectal cancer patients

Survivin inhibitor with chemotherapy provides therapeutic advantage for Rb cells, tumors

Scientists develop graphene-based sensor that can detect harmful air pollution in home

Computer-based cognitive remediation at home can improve cognitive symptoms in MS patients

MGH-led study confirms safety of allergy immunotherapy

Study indicates mRS is poorly suited to evaluate, report quality of neuro-surgery

Developing countries face health financing crisis due to low domestic investment, stagnating international aid

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