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What is the optimal dosing regimen for remdesivir in COVID-19 patients? A computational model

A team of scientists from the Pennsylvania State University, USA, recently analyzed the pharmacodynamics and pharmacokinetics of antiviral drug remdesivir using computational models. Based on the study findings, which are yet to be peer-reviewed, the scientists recommend that for effective inhibition of SARS-CoV-2 infection, remdesivir should be used with other antiviral medicines, or its dosing regimen should be optimized to improve bioavailability.

22 Jun 2021

In a murky sea of mental health apps, consumers left adrift

In the eyes of the tech industry, mental health treatment is an area ripe for disruption.

22 Jun 2021

RedHill presents positive Phase 2 results for oral opaganib in patients with COVID-19 pneumonia

RedHill Biopharma Ltd., a specialty biopharmaceutical company, today announced presentation of the positive Phase 2 safety and efficacy data for oral opaganib (Yeliva®, ABC294640) in hospitalized patients with COVID-19 pneumonia at the World Microbe Forum (WMF) 2021 (poster #: 5574).

21 Jun 2021

FLASH radiotherapy could revolutionize future tumor treatments

It could become a breakthrough for future tumor treatments with heavy ions and pave new ways: In the current experiment period FAIR-Phase 0, the GSI Helmholtzzentrum für Schwerionenforschung and the future accelerator center FAIR succeeded in performing a carbon ion FLASH experiment for the first time.

21 Jun 2021

Dual-antibody combination therapies effective against SARS-CoV-2 variants in animal study

COVID-19 therapies made from antibodies often are given to patients who are at high risk of severe illness and hospitalization. However, there have been nagging questions about whether such antibody therapies retain their effectiveness as worrisome new virus variants arise.

21 Jun 2021

Updated ACR position statement on patient safety and site of service for biologics released

The American College of Rheumatology has released an updated position statement on patient safety and site of service for biologics outlining several reasons why the ACR strongly believes infusions should be administered in a monitored health care setting with onsite supervision by a provider with appropriate training in biologic infusions.

21 Jun 2021

CU Cancer Center secures unique SPORE grant for head and neck cancer research

Research and treatment of head and neck cancers at the University of Colorado Cancer Center reached a new level this month with a highly competitive Specialized Programs of Research Excellence grant from the National Cancer Institute.

21 Jun 2021

Researchers identify four substances that inhibit SARS-CoV-2 replication in cells

Researchers from the German Center for Infection Research at Charité - Universitätsmedizin Berlin and the University of Bonn have examined the way in which SARS-CoV-2 reprograms the metabolism of the host cell in order to gain an overall advantage.

21 Jun 2021

Research identifies SARS-CoV-2 cavities as potential drug targets

New research found the SARS-CoV-2 spike glycoprotein has druggable cavities with the best target being compatible with more than 1 billion compounds.

21 Jun 2021

Zinc inhibits SARS-CoV-2’s main protease in vitro

Zinc has antiviral properties. However, the detailed kinetics and the mechanism of zinc in the inhibition of viruses, particularly SARS-CoV-2 – the causative virus of COVID-19 – is unclear. To probe the role of zinc as an anti-SARS-CoV-2 agent at the structural and molecular level, researchers in India studied the binding kinetics and the inhibition mechanism of zinc with SARS-CoV-2’s viral proteins.

21 Jun 2021

‘It’s a mission’: Volunteers treat refugees massing at the border

El Chaparral Plaza once teemed with tourists, street vendors and idling taxis. But the plaza, just outside the San Ysidro port of entry on the Mexican side of the border, now serves as a sprawling refugee camp where migrants from Mexico, Central America and Haiti wait in limbo while they seek asylum in the U.S.

21 Jun 2021

Nurses and docs at Long Beach Center ‘consider it an honor’ to care for migrant children

The 5-year-old had nodded off while waiting for her 10-year-old brother to be treated for scabies at the clinic in the Long Beach Convention & Entertainment Center, which she currently calls home. Nurse Chai-Chih Huang asked if she wanted to be taken back to her dormitory to sleep.

21 Jun 2021

Can convalescent plasma therapy improve COVID-19 outcomes in patients with hematologic cancers?

A recent study discusses the findings of a study on patients with hematologic cancers who received convalescent plasma therapy following their diagnosis of COVID-19.

21 Jun 2021

Novel interactions between proteins play a critical role in the brain injury recovery process

Patients with brain injury (caused by stroke or trauma) primarily rely on rehabilitation therapy for recovery, as there are no other known effective treatment methods. The rate of recovery from brain injury observed in adults is significantly slower (or the recovery is impossible) than that observed in young children.

21 Jun 2021

Role of tau in pathogenesis of Lewy body dementias is distinct from Alzheimer’s disease, suggests study

Will a reduction in tau protein in brain neurons protect against Parkinson's disease and Lewy body dementias?

21 Jun 2021

New program reveals high burden of undiagnosed or poorly controlled diseases in rural South Africa

A comprehensive health-screening program in rural northern KwaZulu-Natal, South Africa, has found a high burden of undiagnosed or poorly controlled non-communicable diseases, according to a study published in The Lancet Global Health.

21 Jun 2021

New artificial heart can adjust the changing needs of patients treated for end-stage heart failure

An experimental artificial heart includes an autoregulation control mechanism, or Auto-Mode, that can adjust to the changing needs of patients treated for end-stage heart failure.

21 Jun 2021

Novel technique helps evaluate the effect of potential inhibitors on antibiotic-resistant bacteria

Researchers from the Miami University in Ohio have optimized a new technique that will allow scientists to evaluate how potential inhibitors work on antibiotic-resistant bacteria.

21 Jun 2021

New technique can measure metabolic process at the single-cell level

Understanding cellular metabolism - how a cell uses energy- could be key to treating a wide array of diseases, including vascular diseases and cancer.

18 Jun 2021

Blocking IL-11 signaling can promote liver regeneration after paracetamol-induced damage

Scientists at Duke-NUS Medical School and National Heart Centre Singapore, in collaboration with colleagues in Singapore and the UK, have shown that the human form of the signaling protein interleukin 11 (IL-11) has a damaging effect on human liver cells--overturning a prior hypothesis that it could help livers damaged by paracetamol poisoning.

18 Jun 2021

Therapy News and Research

What is the optimal dosing regimen for remdesivir in COVID-19 patients? A computational model

In a murky sea of mental health apps, consumers left adrift

RedHill presents positive Phase 2 results for oral opaganib in patients with COVID-19 pneumonia

FLASH radiotherapy could revolutionize future tumor treatments

Dual-antibody combination therapies effective against SARS-CoV-2 variants in animal study

Updated ACR position statement on patient safety and site of service for biologics released

CU Cancer Center secures unique SPORE grant for head and neck cancer research

Researchers identify four substances that inhibit SARS-CoV-2 replication in cells

Research identifies SARS-CoV-2 cavities as potential drug targets

Zinc inhibits SARS-CoV-2’s main protease in vitro

‘It’s a mission’: Volunteers treat refugees massing at the border

Nurses and docs at Long Beach Center ‘consider it an honor’ to care for migrant children

Can convalescent plasma therapy improve COVID-19 outcomes in patients with hematologic cancers?

Novel interactions between proteins play a critical role in the brain injury recovery process

Role of tau in pathogenesis of Lewy body dementias is distinct from Alzheimer’s disease, suggests study

New program reveals high burden of undiagnosed or poorly controlled diseases in rural South Africa

New artificial heart can adjust the changing needs of patients treated for end-stage heart failure

Novel technique helps evaluate the effect of potential inhibitors on antibiotic-resistant bacteria

New technique can measure metabolic process at the single-cell level

Blocking IL-11 signaling can promote liver regeneration after paracetamol-induced damage

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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