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Persistent loneliness during midlife can increase risk of dementia, Alzheimer’s disease

Being persistently lonely during midlife (ages 45-64) appears to make people more likely to develop dementia and Alzheimer's Disease (AD) later in life. However, people who recover from loneliness, appear to be less likely to suffer from dementia, compared to people who have never felt lonely.

24 Mar 2021

Modeling study predicts SARS-CoV-2 variants with high receptor binding affinity

A new study adds to the sum of knowledge about SARS-CoV-2, with respect to its natural and biologically significant mutations, using computational modeling of the virus-receptor interactions. Understanding how viral mutations affect the virus-host interactions is crucial for shaping proper strategies to control the virus.

24 Mar 2021

Scientists identify a new way to increase enzymes’ life span

Like the parts of a car that make it go, enzymes in living cells can eventually wear out or break over time, and researchers at The University of Western Australia have now discovered what determines an enzyme’s working life and what needs to be done to keep it working longer.

24 Mar 2021

Researchers discover a gene mutation linked to schizophrenia

Researchers at The Feinstein Institutes for Medical Research, in collaboration with Columbia University, have identified a gene mutation that could result in schizophrenia, a chronic brain disorder that affects nearly one percent of the world’s population. T

24 Mar 2021

New technique traces genetic and epigenetic origins of DNA to reveal hidden cancers

A new technique that can trace which tissues and organs the DNA in our blood comes from has been reported today in the open-access eLife journal.

24 Mar 2021

Changes in OASI gene expression increases risk of Alzheimer's and severe COVID-19 infection

Previous research identified the interferon-responsive OAS1 gene as a risk gene for Alzheimer's disease. OAS1 is an enzyme that binds to double-stranded RNA and induces the conformation to create oligoadenylates. They also activate RNase L to break down RNA.

23 Mar 2021

Cellular senescence of cancer-associated fibroblasts play a key role in peritoneal dissemination

Through an analysis of cellular components (cell fractions) from malignant ascites (fluid buildup in the abdomen caused by gastric cancer), a research collaboration based in Kumamoto University (Japan) has demonstrated that cellular senescence of cancer-associated fibroblasts (CAFs) play an important role in the peritoneal dissemination of gastric cancer foci (cells different from surrounding cells).

23 Mar 2021

Genetic study identifies sex-dependent differences in major psychiatric disorders

An analysis of sex differences in the genetics of schizophrenia, bipolar disorder and major depressive disorders indicates that while there is substantial genetic overlap between males and females, there are noticeable sex-dependent differences in how genes related to the central nervous system, immune system, and blood vessels affect people with these disorders.

23 Mar 2021

‘Zombie’ cells come to life after the death of the brain

In the hours after we die, certain cells in the human brain are still active. Some cells even increase their activity and grow to gargantuan proportions, according to new research from the University of Illinois Chicago.

23 Mar 2021

Study reveals a genetic variant linked to COVID-19 severity in young men

A study of young men with COVID-19 has revealed a genetic variant linked to disease severity.

23 Mar 2021

Researcher uses alternative approach to find genetic drivers of rare eye disease

An analysis of thousands of genomes from people with and without the rare eye disease known as MacTel has turned up more than a dozen gene variants that are likely causing the condition to develop and worsen for a significant share of patients.

23 Mar 2021

Nutritional supplement may reduce risk of fatal strokes in patients with rare genetic disorder

Researchers from Children's Hospital of Philadelphia (CHOP) have discovered that a widely used nutritional supplement may significantly reduce the risk of fatal strokes caused by a rare genetic disorder.

23 Mar 2021

IONTAS identifies novel SARS-CoV-2 neutralising antibodies

IONTAS Limited (IONTAS) and FairJourney Biologics S.A (FJB)., leaders in the discovery and optimization of fully human antibodies, have announced the identification of neutralizing antibodies, which bind to multiple emerging SARS-CoV-2 variants.

From FairJourney Biologics 23 Mar 2021

Researchers use layered double hydroxide to increase neuronal growth in mice with spinal cord injuries

Researchers from the Department of Orthopedics of Tongji Hospital at Tongji University in Shanghai have successfully used a nanobiomaterial called layered double hydroxide (LDH) to inhibit the inflammatory environment surrounding spinal cord injuries in mice, accelerating regeneration of neurons and reconstruction of the neural circuit in the spine.

23 Mar 2021

Highly sensitive DNA nanosensor can accurately detect lethal superbugs

The persistent overuse of antibiotics has led to the evolution of antibiotic resistant pathogens, or “superbugs,” which can cause severe life-threatening infections that must be diagnosed and treated early on.

23 Mar 2021

Study identifies metabolic processes associated with multiple, unrelated diseases

Many older, but also increasingly younger, people suffer from several diseases at the same time. Scientists at the Berlin Institute of Health at Charité – Universitätsmedizin Berlin, together with colleagues from Munich and the United Kingdom, have now identified common risk factors that predispose to multiple even seemingly unrelated diseases.

22 Mar 2021

Computational analysis helps identify hematological malignancies that elude the human eye

Myelodysplastic syndrome (MDS) is a disease of the stem cells in the bone marrow, which disturbs the maturing and differentiation of blood cells. Annually, some 200 Finns are diagnosed with MDS, which can develop into acute leukemia. Globally, the incidence of MDS is 4 cases per 100,000 person years.

22 Mar 2021

Study reveals the incidence of structural abnormalities in the developing brain

A large study of brain MRI scans from 11,679 nine- and ten-year-old children reviewed by UC San Francisco neuroradiologists identified potentially life-threatening conditions in 1 in 500 children, and more minor but possibly clinically significant brain abnormalities in 1 out of 25 children.

22 Mar 2021

Researchers test novel gene regulation approach to treat brain diseases

Researchers at the DZNE (Germany), at Massachusetts General Hospital (USA) and at the genomic medicine company Sangamo Therapeutics, Inc. tested a novel gene regulation approach to treat brain diseases such as Alzheimer's in laboratory studies.

22 Mar 2021

Study uncovers mechanism that causes genetic movement disorder

A research team at the Greenwood Genetic Center (GGC) has identified the mechanism that causes movement disorders in patients with mutations in the NUS1 gene.

22 Mar 2021

Genetic News and Research

Persistent loneliness during midlife can increase risk of dementia, Alzheimer’s disease

Modeling study predicts SARS-CoV-2 variants with high receptor binding affinity

Scientists identify a new way to increase enzymes’ life span

Researchers discover a gene mutation linked to schizophrenia

New technique traces genetic and epigenetic origins of DNA to reveal hidden cancers

Changes in OASI gene expression increases risk of Alzheimer's and severe COVID-19 infection

Cellular senescence of cancer-associated fibroblasts play a key role in peritoneal dissemination

Genetic study identifies sex-dependent differences in major psychiatric disorders

‘Zombie’ cells come to life after the death of the brain

Study reveals a genetic variant linked to COVID-19 severity in young men

Researcher uses alternative approach to find genetic drivers of rare eye disease

Nutritional supplement may reduce risk of fatal strokes in patients with rare genetic disorder

IONTAS identifies novel SARS-CoV-2 neutralising antibodies

Researchers use layered double hydroxide to increase neuronal growth in mice with spinal cord injuries

Highly sensitive DNA nanosensor can accurately detect lethal superbugs

Study identifies metabolic processes associated with multiple, unrelated diseases

Computational analysis helps identify hematological malignancies that elude the human eye

Study reveals the incidence of structural abnormalities in the developing brain

Researchers test novel gene regulation approach to treat brain diseases

Study uncovers mechanism that causes genetic movement disorder

Sequencing & Genomics: Elevating Science and Healthcare eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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