Mouse Model News and Research

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Exploring the tantalizing questions about sleep

Sleep is one of the most essential human activities - so essential, in fact, that if we don't get enough sleep for even one night, we may struggle to think, react, and otherwise make it through the day.

11 Apr 2023

How does e-cigarette vapor alter the gut microbiome, body weight, and systemic inflammation levels?

Researchers examine the effects of electronic cigarette (e-cigarette) vapor on gut microbiome, body weight, and systemic inflammation levels.

11 Apr 2023

IU study sheds new light on the development and treatment of rare form of muscular dystrophy

A study by Indiana University School of Medicine researchers sheds new light on the development and treatment of a rare form of muscular dystrophy.

5 Apr 2023

Active compound of a medicinal herb could help fight rheumatoid arthritis

Researchers from OU identified a protein complex involved in the pathogenesis of rheumatoid arthritis.

5 Apr 2023

Biological underpinnings of a reproductive disorder caused by mutation of autism gene

A University of California, Riverside, study has identified the biological underpinnings of a reproductive disorder caused by the mutation of a gene.

5 Apr 2023

Interplay between Western diet, gut microbiota, and cancer development

In a review article published in the journal Seminars in Immunology, scientists have explored the relationship between the Western diet, gut microbiota, and cancer development.

4 Apr 2023

Research provides new insights into the underlying disease mechanisms for polycystic kidney disease

Autosomal dominant polycystic kidney disease (ADPKD) is the most common potentially lethal genetic disease - about a half million people in the United States alone suffer from the condition.

4 Apr 2023

Probiotic E. coli secretes proteins of therapeutic value into its surroundings

Humans are colonized with thousands of bacterial strains. Researchers are now focused on genetically modifying such bacteria to enhance their intrinsic therapeutic properties.

31 Mar 2023

Study focuses on a novel mechanism of the body's regulation of salt balance

A new study led by Marshall University researchers focuses on a novel mechanism of the body's regulation of salt balance.

31 Mar 2023

New type of nanoparticle can deliver messenger RNA encoding useful proteins to the lungs

Engineers at MIT and the University of Massachusetts Medical School have designed a new type of nanoparticle that can be administered to the lungs, where it can deliver messenger RNA encoding useful proteins.

30 Mar 2023

Synthetic hydrogel-based lymphoma tumor model paves way for personalized cancer therapies

In recent years, innovative cancer drugs that target specific molecular drivers of the disease have been embraced as the treatment of choice for many types of cancer.

29 Mar 2023

FDA-approved drug keeps light-sensitive photoreceptors alive in lab models of LCA 10

A National Institutes of Health team has identified a compound already approved by the U.S. Food and Drug Administration that keeps light-sensitive photoreceptors alive in three models of Leber congenital amaurosis type 10 (LCA 10), an inherited retinal ciliopathy disease that often results in severe visual impairment or blindness in early childhood.

29 Mar 2023

NPC1L1-EGFP mice enable researchers to fluorescently visualize, evaluate vesicular endocytosis

Excessive cholesterol absorption from intestinal lumen contributes to the pathogenesis of hypercholesterolemia, which is a well-established risk factor for atherosclerotic cardiovascular disease.

28 Mar 2023

VR imaging system illuminates functional brain network dynamics in autism model

An international research collaboration has developed a VR imaging system that can measure a wide range of neural activity in the cortices of mice during active behavior.

28 Mar 2023

Researchers isolate an IgM exhibiting ultrapotent neutralization from a Zika virus-infected pregnant woman

A recent study published in the Cell Press Journal demonstrated that plasma immunoglobulins of isotype M elicited during pregnancy have an exceptional Zika virus-neutralizing potential.

27 Mar 2023

Bacteria require phase separation to thrive in the mammalian gut

The common commensal gut bacterium Bacteroides thetaiotaomicron uses phase separation of the transcription termination factor Rho to colonize and thrive in the mammalian gut, according to a new study in mice.

17 Mar 2023

Scientists develop genetically defined mouse models for multiple myeloma subtypes

A team of scientists led by Martin Janz and Klaus Rajewsky at the Max Delbrück Center has successfully generated genetically defined mouse models for two subtypes of multiple myeloma.

16 Mar 2023

Researchers shine new light on a potential target for the treatment of diabetic nephropathy

The kidneys perform a critical role in the body by removing waste and excess fluid in the form of urine. In a condition known as diabetic nephropathy, complications from diabetes disrupt the ability of the kidneys to function properly.

15 Mar 2023

Long-acting GIPRA inhibits feeding and lowers body weight in mice with diet-induced obesity

The hormone glucose-dependent insulinotropic polypeptide (GIP) is considered obesogenic. In contrast, GIP receptor agonists (GIPRAs) have shown reduced feeding and body weight in an obese mouse model. Therefore, the precise effects exerted by GIP and GIPRAs remain elusive.

14 Mar 2023

New genetic animal model may inform potential therapeutic options for Down syndrome

National Institutes of Health researchers compared a new genetic animal model of Down syndrome to the standard model and found the updated version to be more similar to the changes seen in humans.

14 Mar 2023

Mouse Model News and Research

Exploring the tantalizing questions about sleep

How does e-cigarette vapor alter the gut microbiome, body weight, and systemic inflammation levels?

IU study sheds new light on the development and treatment of rare form of muscular dystrophy

Active compound of a medicinal herb could help fight rheumatoid arthritis

Biological underpinnings of a reproductive disorder caused by mutation of autism gene

Interplay between Western diet, gut microbiota, and cancer development

Research provides new insights into the underlying disease mechanisms for polycystic kidney disease

Probiotic E. coli secretes proteins of therapeutic value into its surroundings

Study focuses on a novel mechanism of the body's regulation of salt balance

New type of nanoparticle can deliver messenger RNA encoding useful proteins to the lungs

Synthetic hydrogel-based lymphoma tumor model paves way for personalized cancer therapies

FDA-approved drug keeps light-sensitive photoreceptors alive in lab models of LCA 10

NPC1L1-EGFP mice enable researchers to fluorescently visualize, evaluate vesicular endocytosis

VR imaging system illuminates functional brain network dynamics in autism model

Researchers isolate an IgM exhibiting ultrapotent neutralization from a Zika virus-infected pregnant woman

Bacteria require phase separation to thrive in the mammalian gut

Scientists develop genetically defined mouse models for multiple myeloma subtypes

Researchers shine new light on a potential target for the treatment of diabetic nephropathy

Long-acting GIPRA inhibits feeding and lowers body weight in mice with diet-induced obesity

New genetic animal model may inform potential therapeutic options for Down syndrome

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