RNA Sequencing News and Research

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Study may pave the way for a more personalized approach to COVID-19 diagnosis and treatment

Using some of the most advanced molecular sequencing tools available to evaluate COVID-19 rapid autopsy tissues, researchers have identified four major regulatory pathways, specific molecular effectors behind COVID-19 symptoms, and differences that drive diverging clinical courses among individual patients.

11 Nov 2021

Targeting Shp2 in oncological treatments appears to worsen the disease

In recent years, much scientific effort and funding has focused on developing drugs that target an enzyme with the unwieldy name of Src homology 2-containing protein tyrosine phosphatase 2 or more briefly, Shp2.

9 Nov 2021

Identification of a candidate effector gene at COVID-19 risk locus

A new study focuses on developing a comprehensive platform to decode the effects of sequence variation identified by GWAS.

8 Nov 2021

MIT researchers identify link between MEF2 gene and cognitive resilience in older individuals

Many people develop Alzheimer's or other forms of dementia as they get older. However, others remain sharp well into old age, even if their brains show underlying signs of neurodegeneration.

3 Nov 2021

Adaptive immunity in patients infected with SARS-CoV-2 Δ382 Variant

A comprehensive characterization of the immune responses between SARS-CoV-2 infected individuals with wildtype (WT) and Δ382 SARS-CoV-2.

3 Nov 2021

Intussusceptive angiogenesis contributes to tumor growth in metastatic malignant melanoma

For the first time, researchers at the University of Gothenburg have shown that metastases in patients with malignant melanoma gain access to the circulatory system not only through the outgrowth of new blood vessel branches, but also an alternative process in which one blood vessel divide into two parallel vessels bylongitudinal splitting.

26 Oct 2021

Study discloses molecular mechanism of oligodendrocyte myelination by osteocalcin in the CNS

Osteocalcin (OCN) is a multifunctional bone-derived hormone that modulates numerous physiological activities. OCN can cross the blood brain barrier (BBB) and thus play critical roles in neuronal and brain development.

25 Oct 2021

New technology streamlines the development of gene therapy for genetic blinding disorders

A novel computational platform developed by researchers from the University of Pittsburgh School of Medicine identifies top-performing viral vectors that could deliver gene therapies to the retina with maximum efficiency and precision.

19 Oct 2021

Study highlights the critical role of junk DNA in mammalian development

Nearly half of our DNA has been written off as junk, the discards of evolution: sidelined or broken genes, viruses that got stuck in our genome and were dismembered or silenced, none of it relevant to the human organism or human evolution.

19 Oct 2021

Neuroscientists unveil detailed atlas of brain cells

When you clicked to read this story, a band of cells across the top of your brain sent signals down your spine and out to your hand to tell the muscles in your index finger to press down with just the right amount of pressure to activate your mouse or track pad.

6 Oct 2021

Gene expression changes during acute SARS-CoV-2 infection may decide long-COVID symptoms

A team of US-based scientists has recently revealed the changes in gene expression profiles associated with the long-term consequences of COVID-19.

6 Oct 2021

Study reveals how to improve overall immune response against virally driven cancers

Blocking the PD-1 inhibitory pathway within a subset of specialized T-cells may improve overall immune response against virally driven cancers, according to findings published in Nature.

30 Sep 2021

Researchers detect two types of RNA base modifications simultaneously using a quantum sequencer

After a gene is transcribed into RNA, modifications can occur to the subunits or "bases" that make up the RNA molecule, which can affect its structure and function. The study of these changes is known as "epitranscriptomics." These base modifications can occur to most types of RNA molecules, including microRNAs.

29 Sep 2021

Caspase-11 identified as regulator of inflammatory pathology in SARS-CoV-2 infections

New findings identify CASP4/11 as detrimental to inflammation and coagulopathy associated with SARS-CoV-2 infection.

28 Sep 2021

Differences in blood gene expression among patients with varying COVID-19 severity

A new study published on the medRxiv* pre-print server and currently undergoing peer-review aims to answer this question through whole blood transcriptomics of individuals with varying degrees of COVID-19 severity. Transcriptomics, done by RNA sequencing, gives insights into the genes expressed in a cell at a given time point. It gives an analysis of all RNA molecules within a cell, in this case, whole blood.

23 Sep 2021

Researchers use new laser-assisted technology for bioprinting adult neuron cells

A group of researchers including a Concordia PhD student have developed a new method of bioprinting adult neuron cells. They're using a new laser-assisted technology that maintains high levels of cell viability and functionality.

22 Sep 2021

Researchers reveal a mechanism of SHP2-mediated tumor immunosuppression

Colorectal cancer (CRC), a malignant tumor worldwide consists of microsatellite instability (MSI) and stable (MSS) phenotypes. Although SHP2 is a hopeful target for cancer therapy, its relationship with innate immunosuppression remains elusive. To address that, the authors of this article performed single-cell RNA sequencing to explore the role of SHP2 in all cell types of tumor microenvironment (TME) from murine MC38 xenografts.

21 Sep 2021

Differences in DNA methylation could accurately predict progression of liver disease

Findings of a national study led by the Translational Genomics Research Institute, an affiliate of City of Hope, identify potential biomarkers that might eventually be used to diagnose progressive stages of liver disease.

20 Sep 2021

Atopic dermatitis may stem from poorly regulated sex hormones, study suggests

A study led by UT Southwestern dermatologists suggests that a common inflammatory skin condition may stem from poorly regulated sex hormones.

20 Sep 2021

Scientists discover new cell type in human skin that contributes to inflammatory skin diseases

A team of international scientists and clinical experts have unraveled a new cell type in human skin that contributes to inflammatory skin diseases such as atopic dermatitis (AD) and psoriasis (PSO). Their study findings were published in the Journal of Experimental Medicine in September 2021.

17 Sep 2021