Signaling Pathway News and Research

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Vegetable hormone helps reverse brain alterations caused by high-fat diets, obesity

The Neurobiotechnology research team of the Universitat Jaume I in Castellón, Spain, headed by professor Ana María Sánchez, has proven the positive effects of a vegetable hormone, helping reverse brain alterations caused by high-fat diets, type-2 diabetes, obesity and physical inactivity.

3 Oct 2018

No scientific reason available to assume link between BPA uptake and MIH in children

Depending on symptomatic and phenotypic severity the condition of chalky teeth is categorised into three levels. The symptoms of chalky teeth were first described in 1978, with the term molar-incisor hypomineralisation introduced in 2001.

27 Sep 2018

Researchers uncover molecular underpinnings of liver regeneration

In Greek mythology, Zeus punishes the trickster Prometheus by chaining him to a rock and sending an eagle to eat a portion of his liver every day, in perpetuity. It was the right organ to target - the liver has the ability to regenerate itself, though not overnight nor for eternity.

27 Sep 2018

Ipsen receives approval from Health Canada for CABOMETYX tablets for treating renal cell carcinoma

Exelixis, Inc. today announced that its partner Ipsen Biopharmaceuticals Canada Inc. received approval from Health Canada of CABOMETYX® tablets for the treatment of adults with advanced renal cell carcinoma who have received prior vascular endothelial growth factor targeted therapy.

19 Sep 2018

MAPK pathway mediates normal kidney development, reveals study

The prevalence of kidney diseases is growing rapidly due to an aging population and an increased incidence of diseases like diabetes.

14 Sep 2018

Protein involved in milk production appears to stimulate growth and spread of breast cancer

VCU Massey Cancer Center researchers have identified a protein involved in milk production that stimulates the growth and spread of breast cancer and could ultimately serve as a target for novel therapies to treat breast cancer.

12 Sep 2018

NCCN updates Clinical Practice Guidelines to include new recommendations for CABOMETYX tablets

Exelixis, Inc. today announced that the National Comprehensive Cancer Network updated its Clinical Practice Guidelines to include new recommendations for CABOMETYX tablets.

7 Sep 2018

Researchers discover how a protein complex safeguards against certain brain tumors

Researchers have discovered how a molecule can help prevent certain types of brain tumors by recognizing and 'disarming' harmful proteins that cause them.

5 Sep 2018

Research reveals noise-canceling mechanisms in developmental biology

Noise is usually considered a nuisance, for example when preventing us from clearly hearing what someone is saying. The general concept of noise applies more broadly. In biology, the physical differences between organisms of the same type, for example two humans, originate from so-called developmental noise -- ultimately stemming from probabilistic collisions between reacting molecules and environmental conditions in cells during the early stages of the organism's growth.

4 Sep 2018

Novel lentiviral model can determine effect of Wnt/β-Catenin inhibition on bone regeneration

Researchers have developed a novel tool for determining the sensitivity of bone healing to inhibition of the Wnt signaling pathway and have validated its use in a study of bone regeneration in mice.

4 Sep 2018

Dopamine receptor study opens door to targeted treatments for neuropsychiatric disorders

New work from researchers at Columbia University Vagelos College of Physicians and Surgeons sheds light on how dopamine receptors signal within cells, opening the door for more targeted--and more tolerable--therapeutics to treat an array of neuropsychiatric disorders.

4 Sep 2018

Scientists identify 'Achilles heel' of anaplastic large-cell lymphomas

Anaplastic large-cell lymphomas are rare cancers of the white blood cells. New research from the international ERIA consortium, led by scientists in Vienna, has now shown that the same signaling pathway is essential to the growth of cancer cells in various forms of ALCL: TYK2 (tyrosine kinase 2, an important component of the immune system) prevents apoptotic cell death by increasing the production of Mcl1, a special type of protein belonging to the BCL2 family.

3 Sep 2018

Genetic mutations may drive tumor formation by blurring growth signals

Genetic mutations in a form of non-small cell lung cancer (NSCLC) may drive tumor formation by blurring cells' perception of key growth signals, according to a new laboratory study published August 31, 2018 in Science.

3 Sep 2018

Neurons play active role in triggering a defense mechanism that leads to their own damage

Rasmussen's encephalitis is a rare autoimmune disease that primarily affects children and can lead to seizures.

31 Aug 2018

TGHRI scientists detail role of insulin as a boost to the immune system

The role of insulin as a boost to the immune system to improve its ability to fight infection has been detailed for the first time by Toronto General Hospital Research Institute scientists.

30 Aug 2018

Modified T lymphocytes prevent nerve cell damage in encephalitis

Scientists have found a way to prevent neuron death in Rasmussen’s encephalitis, by exploiting T lymphocytes in the immune system.

30 Aug 2018

Dectin-1 pathway could be important new target for treatment of candidiasis, study shows

Candida albicans infection (candidiasis) can cause skin, genital, or oral pain. Many studies have attempted to understand the source of pain in candidiasis; none have provided a clear explanation, until now.

29 Aug 2018

A non-canonical approach may improve radiation treatment for cancer

Although the success or failure of radiation therapy for cancer has long been associated with the intrinsic radio-resistance or radio-sensitivity of tumor cells, a new approach is demonstrating that radiation can take credit for an additional benefit - causing highly effective secondary immune responses that can enhance anti-tumor immunity.

28 Aug 2018

Protein modifications that indicate disease

Researchers from the University of Zurich can, for the first time, precisely characterize the protein modification ADP-ribosylation for all proteins in a tissue sample.

28 Aug 2018

Delivering miRNAs to treat patients with inflammatory bowel disease

Inflammatory bowel disease, such as Crohn disease and ulcerative colitis, are chronic inflammatory diseases of unknown cause, and the number of IBD patients is on the rise.

28 Aug 2018

Signaling Pathway News and Research

Vegetable hormone helps reverse brain alterations caused by high-fat diets, obesity

No scientific reason available to assume link between BPA uptake and MIH in children

Researchers uncover molecular underpinnings of liver regeneration

Ipsen receives approval from Health Canada for CABOMETYX tablets for treating renal cell carcinoma

MAPK pathway mediates normal kidney development, reveals study

Protein involved in milk production appears to stimulate growth and spread of breast cancer

NCCN updates Clinical Practice Guidelines to include new recommendations for CABOMETYX tablets

Researchers discover how a protein complex safeguards against certain brain tumors

Research reveals noise-canceling mechanisms in developmental biology

Novel lentiviral model can determine effect of Wnt/β-Catenin inhibition on bone regeneration

Dopamine receptor study opens door to targeted treatments for neuropsychiatric disorders

Scientists identify 'Achilles heel' of anaplastic large-cell lymphomas

Genetic mutations may drive tumor formation by blurring growth signals

Neurons play active role in triggering a defense mechanism that leads to their own damage

TGHRI scientists detail role of insulin as a boost to the immune system

Modified T lymphocytes prevent nerve cell damage in encephalitis

Dectin-1 pathway could be important new target for treatment of candidiasis, study shows

A non-canonical approach may improve radiation treatment for cancer

Protein modifications that indicate disease

Delivering miRNAs to treat patients with inflammatory bowel disease

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