Research News and Research

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Determinations of breast density could be unreliable, study finds

A systematic review of the scientific literature on dense breasts by researchers at UC Davis and other institutions has found that determinations of breast density can be unreliable and that as many as 19 percent of women are re-categorized as dense rather than non-dense or vice versa from one mammogram to the next.

12 Jan 2016

New USPSTF breast cancer screening recommendations may result in lethal consequences for women

If followed, new U.S. Preventive Services Task Force breast cancer screening recommendations will result in thousands of unnecessary deaths each year and thousands more women enduring extensive and expensive treatment than if their cancer had been found early by an annual mammogram.

12 Jan 2016

Researcher seeks to identify probiotic mixes to treat Clostridium difficile infections

Antibiotics that fight infection can adversely affect the digestive tract and give destructive bacteria a chance to flourish, said assistant professor of veterinary and biomedical sciences Joy Scaria of South Dakota State University. His research seeks to identify probiotic mixes to treat intestinal infections, such as Clostridium difficile.

12 Jan 2016

MD Anderson-led study explores role of HIF-1 in triple-negative breast cancer

A multi-institutional international study led by scientists at The University of Texas MD Anderson Cancer Center has revealed new information about how molecules called long non-coding RNAs (lncRNA) interact with HIF-1, a signaling pathway that is overexpressed in many cancers. HIF-1 has been shown to regulate breast cancer progression.

12 Jan 2016

Coordinated care approach to diabetes self-management benefits underserved adult populations

Even in communities with barriers to health care, exercise opportunities and healthy food, residents with diabetes saw improved health outcomes when they participated in programs that took a coordinated care approach to diabetes self-management.

12 Jan 2016

iCardiac provides industry-wide dataset access to enable broader validation of TQT alternative approach

iCardiac Technologies, Inc., a scientific leader in the conduct of cardiac safety assessments, today announced it is providing industry-wide access to its pivotal dataset as part of an effort announced by the Cardiac Safety Research Consortium to enable broader validation of an alternative approach to the Thorough QT (TQT) study.

12 Jan 2016

Drugs that block KDM4C and PRMT1 genes could be effective in treating AML

Two genes have been identified that are critical to the development of the biggest leukaemia killer, acute myeloid leukaemia (AML). Researchers at King’s College London found that drugs that selectively block these genes could be highly effective in treating this type of leukaemia.

12 Jan 2016

New article suggests that playing American football may contribute to hypertension

As National Football League playoff games are underway, a new article published in the "Hypotheses" section of the January 2016 issue of The FASEB Journal, suggests that the toll the sport takes on players' bodies extends beyond head trauma and damage to limbs and joints. The trauma and damage associated with football participation may also be linked to elevations in blood pressure through immune system activation and inflammation.

12 Jan 2016

AbbVie begins six global Phase 3 clinical studies to evaluate efficacy of investigational HCV regimen

AbbVie, a global biopharmaceutical company, today announced the initiation of six global Phase 3 clinical studies evaluating the safety and efficacy of its all-oral, once-daily, ribavirin-free investigational hepatitis C virus (HCV) regimen, ABT-493, an NS3/4A protease inhibitor, and ABT-530, an NS5A inhibitor, in patients with genotypes 1-6 (GT1-6) chronic HCV infection.

12 Jan 2016

NUS researchers develop EsoGlove that helps patients restore hand functions

Patients who have lost their hand functions due to injuries or nerve-related conditions, such as stroke and muscular dystrophy, now have a chance of restoring their hand movements by using a new lightweight and smart rehabilitation device called EsoGlove developed by a research team from the National University of Singapore.

12 Jan 2016

Cancer concerns over chromium diet pills

Concerns have been raised over the long-term use of nutritional supplements containing chromium, after an Australian research team found the supplement is partially converted into a carcinogenic form when it enters cells.

12 Jan 2016

Synpromics, Cell Therapy Catapult to create stable producer cell lines for large-scale manufacture of viral vectors

Synpromics Ltd, a leading synthetic biology company, and The Cell Therapy Catapult, the UK organisation accelerating the growth of the UK cell and gene therapy industry by bridging the gap between scientific research and commercialisation, today announce the launch of a collaboration to remove a major barrier to the development of the cell and gene therapy industry by reducing the cost and increasing the scale and efficiency of viral vector manufacturing.

12 Jan 2016

Cholesterol-lowering drug simvastatin could become effective treatment for Parkinson's

A clinical trial using cholesterol-lowering treatment Simvastatin in people living with Parkinson's is getting underway in centres across the country -- with the hope that it could become one of a number of effective treatments available to treat Parkinson's.

12 Jan 2016

Higher-fat DASH diet significantly reduces blood pressure and triglycerides

The Dietary Approaches to Stop Hypertension (DASH) dietary pattern, which is high in fruits, vegetables and low fat dairy foods, significantly lowers blood pressure as well as low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol.

12 Jan 2016

Study opens new door on the causes of vision issues in astronauts

Just when you think you've seen it all, our eyes look to be victims of a low-gravity environments, too. According to new research published in the January 2016 issue of The FASEB Journal, two significant genetic differences in enzymes that direct the one-carbon pathway of metabolism can affect astronaut vision.

12 Jan 2016

Discoveries could lead to development of novel therapies to prevent C. diff infection

Researchers at Vanderbilt University Medical Center have obtained the crystal structure of a toxin from the bacterium Clostridium difficile ("C. diff") -- the leading cause of hospital-acquired diarrhea in the United States.

12 Jan 2016

GPR119 could be a potential treatment target for nonalcoholic fatty liver disease

New research published in the January 2016 issue of The FASEB Journal suggests that the G-protein-coupled receptor 119 (GPR119) could be a viable treatment target for nonalcoholic fatty liver disease. This receptor has already been identified as a drug target for diabetes and obesity, and this report raises hopes that compounds that target GPR119 for diabetes or obesity might also work for non-alcoholic fatty liver disease.

12 Jan 2016

Researchers take major step towards developing vaccine for river blindness

The world's first vaccine for a disease that causes misery for millions in Africa could be tested within five years.

12 Jan 2016

Novel anti-inflammatory agents could control hyper-inflammatory responses to fungal infection

The most frequent fungal threat to humans, Candida albicans, is a common cause oral and genital infection. The fungal infections are often worsened by overwhelming inflammatory responses in the body and cause high mortality among risk groups. Umeå University doctoral student Ava Hosseinzadeh has discovered two novel anti-inflammatory agents, an antioxidant and an anti-inflammatory molecule, which could be used to control the hyper-inflammatory responses to the fungal infection.

12 Jan 2016

Excess folic acid intake causes lowered immune function in aged mice

Previous studies have shown an association between high folic acid intake and a reduction in the immune system defenses needed to fight viral infections and cancer. In a new study in mice published in the Journal of Nutritional Biochemistry, scientists at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University set out to determine if excess folic acid intake caused adverse changes in the immune system.

12 Jan 2016

Research News and Research

Determinations of breast density could be unreliable, study finds

New USPSTF breast cancer screening recommendations may result in lethal consequences for women

Researcher seeks to identify probiotic mixes to treat Clostridium difficile infections

MD Anderson-led study explores role of HIF-1 in triple-negative breast cancer

Coordinated care approach to diabetes self-management benefits underserved adult populations

iCardiac provides industry-wide dataset access to enable broader validation of TQT alternative approach

Drugs that block KDM4C and PRMT1 genes could be effective in treating AML

New article suggests that playing American football may contribute to hypertension

AbbVie begins six global Phase 3 clinical studies to evaluate efficacy of investigational HCV regimen

NUS researchers develop EsoGlove that helps patients restore hand functions

Cancer concerns over chromium diet pills

Synpromics, Cell Therapy Catapult to create stable producer cell lines for large-scale manufacture of viral vectors

Cholesterol-lowering drug simvastatin could become effective treatment for Parkinson's

Higher-fat DASH diet significantly reduces blood pressure and triglycerides

Study opens new door on the causes of vision issues in astronauts

Discoveries could lead to development of novel therapies to prevent C. diff infection

GPR119 could be a potential treatment target for nonalcoholic fatty liver disease

Researchers take major step towards developing vaccine for river blindness

Novel anti-inflammatory agents could control hyper-inflammatory responses to fungal infection

Excess folic acid intake causes lowered immune function in aged mice

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