Protein News and Research

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Proteins are complex molecules that are made up of amino acids. They can be found in every cell in the body, and carry out vital processes that keep human beings alive. Mutations in proteins can lead to a multitude of diseases, the most common being cancer.

Novel targets for treating sorafenib-resistant hepatocellular carcinoma found using CRISPR-Cas9 screening

This study is led by Xiujun Cai (Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University School of Medicine). Professor Xiujun Cai's research team screened the whole genome of hepatocellular carcinoma cells (HepG2) through CRISPR / cas9 system under sorafenib treatment, and screened the dominant gene in sorafenib resistance.

20 Apr 2022

New deep learning neural network model predicts physical interactions of protein complexes

From the muscle fibers that move us to the enzymes that replicate our DNA, proteins are the molecular machinery that makes life possible.

20 Apr 2022

Researchers uncover a new protective mechanism against non-alcoholic fatty liver disease

Non-alcoholic fatty liver disease (NAFLD), commonly known as fatty liver disease, is a prevalent disease frequently seen in obese people. Having high fat content in the liver is detrimental as it is strongly associated with severe health problems like diabetes, high blood pressure, and liver cancer.

20 Apr 2022

Type I interferon found to be major driver of memory, cognitive loss in Alzheimer's disease mouse model

Alzheimer's disease (AD), the most common type of dementia, progressively impairs memory, concentration and the ability to learn new things and accomplish everyday activities.

19 Apr 2022

Levels of little-studied enzyme found to decline with age and more dramatically with Alzheimer’s

A little-studied enzyme has been found in high levels in healthy neurons, levels that scientists say decline with age and more dramatically with Alzheimer's, making adjusting the enzyme's level a potential treatment for both.

19 Apr 2022

Newly identified mechanism explains how fine air pollution particles may cause lung cancer

Scientists have identified a mechanism that explains how fine air pollution particles might cause lung cancer, according to a study published today in eLife.

19 Apr 2022

Researchers reveal possible way to treat newborns with rare genetic lung condition

When babies are born with alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV), their skin starts to turn blue from the under-oxygenated blood in their systems.

19 Apr 2022

Researchers discover a novel signaling pathway that defines interferon responses in blood cancers

Northwestern Medicine investigators have discovered a novel signaling pathway activated by interferons, a group of immune system proteins, that suppresses the anti-tumor response of interferons in patients with a particular type of blood cancer, according to findings published in Nature Communications.

19 Apr 2022

Researchers investigate Zika virus and Dengue virus co-immunity

In a new study, researchers successfully created new strains of the Zika virus and proved that the process of passaging through mice resulted in significantly increased virulence.

19 Apr 2022

Using customized 'mini-antibodies' to mitigate chronic inflammation

Researchers at the Universities of Bonn and Sao Paulo have succeeded in mitigating chronic inflammation in mice using customized "mini-antibodies."

19 Apr 2022

New therapeutic option for HPV-positive head and neck carcinoma discovered

The various manifestations of head and neck carcinomas rank sixth in frequency worldwide and are fatal for about half a million people every year. In a quarter of cases, head and neck squamous cell carcinoma (HNSCC) is caused by human papillomavirus (HPV) and, currently, is not always treatable.

19 Apr 2022

Small genetic differences can affect the ability to utilize energy of various nutrients, study finds

Carbohydrates, proteins and fats are essential nutrients to all animals. Yet dietary variation between species, populations and individuals can vary dramatically.

19 Apr 2022

Why cheap, older drugs that might treat covid never get out of the lab

In March 2020, Dr. Joseph Vinetz left the contemplative world of his Yale University infectious-disease laboratory and plunged into the covid ward at Yale New Haven Hospital, joining an army of health care workers who struggled to treat the deadly viral disease.

19 Apr 2022

New study pinpoints how immune checkpoint protein LAG3 modulates T cell activity

Fighting cancer and chronic disease is tiring work for the immune system. When T cells are engaged in this kind of lengthy battle, they can become exhausted, or unable to function properly.

18 Apr 2022

Better understanding of hydrocephalus could lead to improved treatments

Hydrocephalus, or "water on the brain," occurs when the cerebral ventricles - four interconnected cavities of the brain that are filled with cerebrospinal fluid - become enlarged, but its cause is unknown in many cases.

18 Apr 2022

The brain's reaction to COVID's inflammatory tidal wave

Researchers study neuroinflammation in the cerebrospinal fluid and serum of patients infected with SARS-CoV-2.

18 Apr 2022

Research shows tsRNA as a promising biomarker for early diagnosis of hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is the most primary liver cancer. It is one of the most common and mortal cancer worldwide, especially in East Asia. Advanced HCC patients expect a significantly low 5-year survival rate as well as poor prognosis.

18 Apr 2022

Study investigates the production of a virosome-based COVID-19 vaccine candidate

In a new study, different signal peptides, baculovirus transfer vectors, cell lines, infection techniques, and formulation buffers were investigated with the purpose of building a scalable bioprocess to generate high-quality S protein for incorporation in a virosome-based COVID-19 vaccine candidate.

18 Apr 2022

Researchers uncover a key regulator of pregnancy-associated heart growth

Northwestern Medicine scientists have uncovered a key regulator of pregnancy-associated heart growth, according to a recent study published in the Journal of Clinical Investigation.

18 Apr 2022

The involvement of the skeletal muscles in long COVID-19

Researchers reviewed the mechanisms of muscle tissue injury, aggravating conditions, and associated sequelae in long COVID‐19.

18 Apr 2022

Protein News and Research

Further Reading

Novel targets for treating sorafenib-resistant hepatocellular carcinoma found using CRISPR-Cas9 screening

New deep learning neural network model predicts physical interactions of protein complexes

Researchers uncover a new protective mechanism against non-alcoholic fatty liver disease

Type I interferon found to be major driver of memory, cognitive loss in Alzheimer's disease mouse model

Levels of little-studied enzyme found to decline with age and more dramatically with Alzheimer’s

Newly identified mechanism explains how fine air pollution particles may cause lung cancer

Researchers reveal possible way to treat newborns with rare genetic lung condition

Researchers discover a novel signaling pathway that defines interferon responses in blood cancers

Researchers investigate Zika virus and Dengue virus co-immunity

Using customized 'mini-antibodies' to mitigate chronic inflammation

New therapeutic option for HPV-positive head and neck carcinoma discovered

Small genetic differences can affect the ability to utilize energy of various nutrients, study finds

Why cheap, older drugs that might treat covid never get out of the lab

New study pinpoints how immune checkpoint protein LAG3 modulates T cell activity

Better understanding of hydrocephalus could lead to improved treatments

The brain's reaction to COVID's inflammatory tidal wave

Research shows tsRNA as a promising biomarker for early diagnosis of hepatocellular carcinoma

Study investigates the production of a virosome-based COVID-19 vaccine candidate

Researchers uncover a key regulator of pregnancy-associated heart growth

The involvement of the skeletal muscles in long COVID-19

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