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MIT researchers describe new methods for accelerating drug approvals during pandemics

In response to the COVID-19 pandemic, researchers from the Massachusetts Institute of Technology have published a pair of studies in a COVID-19 special issue of the Harvard Data Science Review, freely available via open access, describing new methods for accelerating drug approvals during pandemics and for providing more accurate measures of the probabilities of success for clinical trials of vaccines and other anti-infective therapies.

20 May 2020

Researchers highlight the need to revise the protocol for detecting ZIKV infection in placenta

Shortly after the explosion in microcephaly cases caused by Zika virus in Brazil in 2015-16, several scientific studies were published with evidence that the pathogen is capable of crossing the human placenta, the organ that keeps the fetus connected to the mother's body during pregnancy.

20 May 2020

Mitigating challenges encountered by individuals with ASD in COVID-19 era

The COVID-19 pandemic is stressful enough, but for children and adults with autism spectrum disorder (ASD) and their families, the crisis can be especially difficult.

20 May 2020

Henry Ford Health System first to enroll a pediatric patient in HEROS study

Henry Ford Health System is first in the country to enroll a patient in the Human Epidemiology and Response to SARS-CoV-2 study, which aims to help determine the rate of SARS-CoV-2, the virus that causes COVID-19, among U.S. children and their family members, and what percentage of children infected with SARS-CoV-2 develop symptoms of the disease.

20 May 2020

Study shows engineered SARS-CoV-2 spike protein may be utilized for vaccine development

In a new study available on the preprint server bioRxiv, researchers demonstrate how the conformation of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein (S-protein) can be controlled with the rational construct design, providing a framework for S-protein structure engineering in vaccine/drug development.

20 May 2020

Scientists develop novel flow cytometry technique to quantify protein production in T-cells

A team of scientists from Hollings Cancer Center at the Medical University of South Carolina (MUSC) has developed a novel flow cytometry technique that can, for the first-time, quantify protein production in T-cells.

20 May 2020

Scientists use machine learning methods to estimate COVID-19's seasonal cycle

One of the many unanswered scientific questions about COVID-19 is whether it is seasonal like the flu - waning in warm summer months then resurging in the fall and winter.

20 May 2020

Doctoral candidate receives NIH fellowship to study how adenovirus affects heart function

A dose of adenovirus hits most people like a common cold - a cough, a fever, maybe a sore throat. But for an unfortunate few, the usually benign bug hacks the heart's cellular electrical communication system and sometimes proves fatal.

20 May 2020

Immunologists propose possible molecular mechanism for the deadly respiratory syndrome

Research into how the SARS-CoV-2 virus induces death is suggesting potential treatments for its most destructive complications.

20 May 2020

Mount Sinai venture to develop and scale distribution of COVID antibody test kits

Mount Sinai Health System ("Mount Sinai") and Renalytix AI today announced the formation of Kantaro Biosciences, LLC ("Kantaro"), a Mount Sinai venture, to develop and scale production and distribution of a test kit based on the Mount Sinai-developed high-performance serologic assay for SARS-CoV-2 antibodies.

20 May 2020

Methodologies to detect the presence of SARS-CoV-2

In an important, comprehensive, and timely review, an expert team from the University of California Berkeley details the methodologies used in nucleic acid-based tests for detecting the presence of SARS-CoV-2, the virus that causes COVID-19.

20 May 2020

Researchers describe new methods to speed up drug approvals during pandemics

20 May 2020

Retrofitted VW diesel engines emit less harmful nitrogen oxides

The VW diesel scandal began with a bang on September 18, 2015. On exactly the opening day of the Frankfurt International Motor Show (IAA), the US Environmental Protection Agency (EPA) published its "Notice of Violation": VW diesel engines with 1.6 and 2.0 liters displacement (type code EA 189) contained illegal software designed to manipulate emissions.

20 May 2020

Study could help identify more targeted treatments for ovarian cancer

The rogue cellular engine that drives a majority of ovarian cancers remains frustratingly difficult to disable. A new study comparing cancerous tissue with normal fallopian tube samples advances important insights about this machinery and confirms biological hallmarks of survival.

20 May 2020

Researchers develop novel method to diagnose and monitor autoimmune disorders

Researchers from Prokhorov General Physics Institute of the Russian Academy of Sciences and the Moscow Institute of Physics and Technology have developed a novel method for diagnosing and monitoring autoimmune disorders.

19 May 2020

Researchers propose a safer approach to splitting ventilators

As more Covid-19 patients experience acute respiratory distress, there has been much debate over the idea of sharing ventilators, which involves splitting air tubes into multiple branches so that two or more patients can be connected to the same machine.

19 May 2020

Did SARS-CoV-2 adapt to humans long before the index case?

A new study from Canada and the U.S. suggests that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may have already been pre-adapted to human transmission when it emerged in late 2019, which means there may be lingering populations of progenitor SARS-CoV-2 adept for human transmission and coronavirus disease (COVID-19) re-emergence. The research is published on the preprint server bioRxiv in May 2020.

19 May 2020

Early life antibiotic exposure linked to increased risk of childhood obesity

Very young children exposed to antibiotics at an early age (from birth to 12 months) are associated with higher risks of childhood obesity and increased adiposity in early to mid-childhood.

19 May 2020

New biodegradable food packaging prolongs food shelf life

Plastic pollution and disposal of single use plastic packaging is a huge sustainability issue in need of innovative solutions: latest results from the EU-funded project YPACK show that an innovative formulation of active ingredients could allow this biodegradable food packaging to prolong the shelf life of foods and therefore reduce food waste.

19 May 2020

Phase IIB clinical trial initiated for treating hepatitis B-associated liver cancer

The first patients have been dosed in a multi-regional Phase IIB randomized, placebo-controlled clinical trial for the treatment of hepatitis B-associated liver cancer.

19 May 2020

Laboratory News and Research

MIT researchers describe new methods for accelerating drug approvals during pandemics

Researchers highlight the need to revise the protocol for detecting ZIKV infection in placenta

Mitigating challenges encountered by individuals with ASD in COVID-19 era

Henry Ford Health System first to enroll a pediatric patient in HEROS study

Study shows engineered SARS-CoV-2 spike protein may be utilized for vaccine development

Scientists develop novel flow cytometry technique to quantify protein production in T-cells

Scientists use machine learning methods to estimate COVID-19's seasonal cycle

Doctoral candidate receives NIH fellowship to study how adenovirus affects heart function

Immunologists propose possible molecular mechanism for the deadly respiratory syndrome

Mount Sinai venture to develop and scale distribution of COVID antibody test kits

Methodologies to detect the presence of SARS-CoV-2

Researchers describe new methods to speed up drug approvals during pandemics

Retrofitted VW diesel engines emit less harmful nitrogen oxides

Study could help identify more targeted treatments for ovarian cancer

Researchers develop novel method to diagnose and monitor autoimmune disorders

Researchers propose a safer approach to splitting ventilators

Did SARS-CoV-2 adapt to humans long before the index case?

Early life antibiotic exposure linked to increased risk of childhood obesity

New biodegradable food packaging prolongs food shelf life

Phase IIB clinical trial initiated for treating hepatitis B-associated liver cancer

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