Developmental Biology News and Research

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Plant stem cell breakthrough made

Totipotent stem cells allow plants to build new organs throughout their whole life. But it has been unclear how hormones and genetic factors work together to prevent plants from having growth that is either stunted, or uncontrolled and tumor-like. Scientists from the Max Planck Institute for Developmental Biology have now uncovered a feedback mechanism, involving a growth-enhancing hormone and a regulatory protein, which controls the number of stem cells the plant produces.

22 Dec 2005

Researchers link microRNA - miR 196 - to limb development

A tiny strand of molecules plays a role in how our arms and legs develop and grow - a finding that sheds light on perplexing bits of material once dismissed as genetic "junk," say scientists at the University of Florida and Harvard University.

5 Dec 2005

Discovery of novel form of regulation of the GLI1 gene

The Quaking gene, first described as a mutation in mice that causes rapid tremor, is thought to suppress tumor formation and protect humans from cancer.

14 Nov 2005

Researchers determine how Tsg101 gene controls cellular growth

Researchers at Emory University School of Medicine and their colleagues have discovered a genetic mechanism that controls cellular growth in the fruit fly Drosophila melanogaster, and believe it likely that a similar system may be at work in normal and cancerous human cells.

1 Nov 2005

Method to count the absolute number of individual protein molecules inside a living cell

Yale researchers have reported a method to count the absolute number of individual protein molecules inside a living cell, and to measure accurately where they are located, two basic hurdles for studying biology quantitatively.

20 Oct 2005

Fear of falling gait

The patient came into the doctor's office in a wheelchair, weighted down by a diagnosis of Parkinson's disease, taking medication for the disorder and insisting she was unable to stand or walk. Thirty minutes later, after jogging down the hallway, she strolled out the door.

9 Oct 2005

Tumor formation is generated by a complex interaction of both mechanical as well as chemical signals

The relationship between tissue rigidity and tumor formation is fairly well established; however, what is not so well understood is what happens on a molecular level that contributes to such stiffness.

26 Sep 2005

Workshop - stem cells in reproduction and in the brain

"Once we have found the factors by which body cells can be re-programmed into stem cells, then therapeutic cloning might become superfluous," said Hans R. Scholer, director of the Max Planck Institute for Molecular Biomedicine in Munster, Germany, at an international scientific symposium on stem cell research in Kobe, Japan.

10 Sep 2005

Why do estrogen-dependent breast-cancer cells grow and spread rapidly?

Researchers at the University of Illinois at Urbana-Champaign say it may be because estrogen virtually eliminates levels of a vitally important regulatory protein.

10 Sep 2005

Adult stem cells may play a role in the development of some forms of cancer

Researchers at UT Southwestern Medical Center have determined that stem cells in a certain region of the brain may be the source of a particular type of incurable brain tumor and may be implicated in other types of brain cancers as well.

16 Aug 2005

Factors inhibiting the brain's natural self-healing process identified

Factors that inhibit the brain's natural self-healing process and that may offer new insights into how to prevent brain damage in premature babies have been identified by a team of researchers supported in part by the March of Dimes.

7 Aug 2005

Scientist have found an unexpected effect of the interaction of PTEN and p53 genes in early stage prostate cancer

Prostate cancer, the second leading cause of cancer death for men in the United States, is caused by changes in several tummor suppressor genes including PTEN and p53. Up to 70 percent of men with prostate cancer have lost one copy of the PTEN gene at the time of diagnosis, and p53 is absent in a high number of patients with advanced prostate cancer.

3 Aug 2005

Extraordinary number of genes are required for prenatal mammalian development

A team of scientists led by Cornell University's Dr. John Schimenti reports today that an extraordinary number of genes are required for prenatal mammalian development. The researchers estimate that up to 19% of all genes are vital for embryogenesis in mice.

17 Jul 2005

Researchers find molecule ephrin-B3 inhibits regrowth of spinal nerve cells

A molecule that helps the body's motor nerve cells grow along proper paths during embryonic development also plays a major role in inhibiting spinal-cord neurons from regenerating after injury, researchers at UT Southwestern Medical Center have found.

11 Jul 2005

New initiative to provide $600k to fund new research into Down Syndrome

Today the University of Colorado and The Anna and John J. Sie Foundation of Denver announced The Sie Family Down Syndrome Break-Through Research Initiative. The initiative will provide $600,000 in grant funds to stimulate new scientific research on Down syndrome with the aim of enhancing cognitive ability. These are the first such grants provided to CU for a specific chromosomal condition and the first nationwide specifically for Down syndrome.

1 Jul 2005

Old skin fungus drug has been found to be a possible cancer treatment

A drug that has been used for 40 years for the treatment of skin fungus has been found to be a possible cancer treatment, according to an international team of scientists. Leslie Wilson, professor of biochemistry and pharmacology at the University of California, Santa Barbara, said that the antifungal drug, griseofulvin, has been shown to inhibit the growth of cancer cells in his laboratory.

30 Jun 2005

Uncomplicated twin pregnancies might be more risky than previously thought

As mothers get older and assisted conception becomes more common, the incidence of multiple births - primarily of nonidentical siblings, but also of identical ones - has dramatically increased.

28 Jun 2005

Columbia University launches multi-year campaign to support stem cell researc

Columbia University Medical Center (CUMC) has announced that it is halfway toward realizing the first phase of a multi-year campaign to build upon the university’s groundbreaking stem cell research and lead the effort to fully realize the therapeutic potential of stem cells.

16 Jun 2005

Technology for analyzing gene expression must be standardized

Technology for analyzing gene expression must be standardized among laboratories and across platforms around the world to support this age of human genome exploration, an Oregon Health & Science University researcher says.

29 May 2005

Retina and its circuits are much more pliable than scientists previously thought

A new Oregon Health & Science University study is opening scientists' eyes to the retina's ability to rewire itself so it can adapt to different levels of ambient light.

26 May 2005