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Common rubber products can cause contact allergy: Study

Common rubber products can form isothiocyanates in contact with skin and cause contact allergy. This is the conclusion of research carried out at the University of Gothenburg. Isothiocyanates are a group of reactive substances that are potent contact allergens.

12 Jan 2011

Research could lead to new approaches to treat dementia

A researcher at the University of Pittsburgh School of Medicine, in collaboration with scientists from the National Institutes of Health, has discovered that the deadly plaques of Alzheimer's disease interact with certain cellular proteins to inhibit normal signals that maintain blood flow to the brain.

11 Jan 2011

Silicon microdevices may provide new way to screen metastatic breast cancer cells

Research by engineers and cancer biologists at Virginia Tech indicate that using specific silicon microdevices might provide a new way to screen breast cancer cells' ability to metastasize.

11 Jan 2011

GSK, Epizyme enter partnership to discover, develop, and market epigenetic therapeutics

Epizyme today announced a worldwide strategic alliance with GlaxoSmithKline to discover, develop, and market novel small molecule therapeutics targeting histone methyltransferases, an important class of epigenetic enzymes, for the treatment of cancer and other diseases.

11 Jan 2011

Study: Protein that plays a key role in some antioxidant therapies can promote atherosclerosis

UCLA researchers have found that a protein that plays an important role in some antioxidant therapies may not be as effective due to additional mechanisms that cause it to promote atherosclerosis, or clogging of the arteries.

11 Jan 2011

Enobia Pharma completes ENB-0040 Phase II study in juveniles with hypophosphatasia

Enobia Pharma, today announced that it has successfully completed a Phase II study of ENB-0040, a bone targeted enzyme replacement therapy being investigated in juveniles with hypophosphatasia, a serious, rare metabolic bone disorder.

10 Jan 2011

AMT enters agreement with Consortium for clinical development of novel gene therapy to treat Sanfilippo B

Amsterdam Molecular Therapeutics, a leader in human gene therapy, announced today that it has entered into an agreement with Institut Pasteur, Paris, France, and a group of French research institutes (together the "Consortium") to support clinical development of a novel gene therapy to treat Sanfilippo B.

10 Jan 2011

Two signaling molecules communicate across nerve cells to regulate electrical, chemical activity: Study

In the Old West, camps sent smoke signals across distances to share key developments or strategy. Likewise, two important signaling molecules communicate across nerve cells to regulate electrical and chemical activity, neuroscientists from the UT Health Science Center San Antonio reported today.

10 Jan 2011

Study finds link between nonalcoholic fatty liver disease and stroke

People suffering from fatty liver disease may be three times more likely to suffer a stroke than individuals without fatty liver, according to a study by researchers at St. Michael's Hospital and the London Health Sciences Centre.

10 Jan 2011

Specific silicon microdevices may provide new way to screen metastatic breast cancer cells

Research by engineers and cancer biologists at Virginia Tech indicate that using specific silicon microdevices might provide a new way to screen breast cancer cells' ability to metastasize.

9 Jan 2011

Vaccines for alcoholism and cocaine addiction coming soon

In a latest development, researchers from Chile have come up with a vaccine to cure alcoholics. It will help them kick the habit by creating a sensation of a terrible hangover after just a few drinks. The mechanism by which this vaccine acts is by neutralizing a group of enzymes that help the body to break down alcohol. When the enzymes aldehyde dehydrogenase is disabled the body accumulates the alcohol to create the hangovers after just a few drinks.

9 Jan 2011

Green tea may help in Alzheimer’s disease: Study

A new study finds that a cup of green tea may protect against Alzheimer’s disease and other forms of dementia. The researchers looked at the effects of a concentrated green tea extract that had been treated in the laboratory to mimic the effects of normal digestion.

9 Jan 2011

Cells that give rise to neurons maintain high levels of ROS

For years, the majority of research on reactive oxygen species (ROS) - ions or very small molecules that include free radicals - has focused on how they damage cell structure and their potential link to stroke, cardiovascular disease and other illnesses.

7 Jan 2011

Research says regular intake of green tea can prevent Alzheimer's disease

Regularly drinking green tea could protect the brain against developing Alzheimer's and other forms of dementia, according to latest research by scientists at Newcastle University.

6 Jan 2011

Omeros receives exclusive license for new series of antifibrinolytic agents

Omeros Corporation (Nasdaq: OMER) today announced that it has obtained an exclusive license from The Regents of the University of California to a new series of antifibrinolytic agents. These optimized agents represent a significant potential advance in the control of surgical and traumatic bleeding.

6 Jan 2011

Investigators receive two Alpha-1 Foundation grants for research on lung disorder

The Alpha-1 Foundation announced today that it has awarded two research grants to investigators whose research will contribute to our understanding of the causes and mechanisms that give rise to lung disease.

6 Jan 2011

ReproCELL to enter collaborative iPS cell-derived hepatocytes R&D agreement with NIBIO

ReproCELL, Inc. (CEO: Chikafumi Yokoyama PhD) announces today that the company will enter a collaborative R&D agreement with the National Institute of Biomedical Innovation (NIBIO; Director General: Koichi Yamanishi; Osaka, Japan), which could offer new hepatocyte derived from human iPS (induced pluripotent stem) cells used for an effective in-vitro drug screening for hepatic toxicity and liver metabolism.

5 Jan 2011

Anaphylatoxin C5a may be responsible for devastating effects of atherosclerosis

For decades, doctors have looked at fitness levels, weight, and overall health risk factors for heart disease and stroke. Now, they may soon add a new risk factor to the list: activation of the complement system. The complement system is usually implicated in immune responses, but now there's a role for it in cardiovascular disease.

5 Jan 2011

Critical tuning dial for controlling whole body energy

Researchers have found what appears to be a critical tuning dial for controlling whole body energy, according to a new report in the January issue of Cell Metabolism, a Cell Press publication. When energy levels within cells drop, it sets off a series of events designed to increase the amount of calorie-rich dietary fat that the body will absorb.

5 Jan 2011

Blocking activation of delta-PKC enzyme could protect lungs from neutrophil-mediated damage

All of us may be able to breathe a little easier now that scientists from Pennsylvania have found a new therapeutic target for controlling dangerous inflammation in the lungs. A new research report in the January 2011 issue of the Journal of Leukocyte Biology (http://www.jleukbio.org) suggests that blocking the activation of an enzyme called delta-protein kinase C (delta-PKC) could protect the lungs from neutrophil-mediated damage, which can result in out of control inflammation.

5 Jan 2011

Enzyme News and Research

Common rubber products can cause contact allergy: Study

Research could lead to new approaches to treat dementia

Silicon microdevices may provide new way to screen metastatic breast cancer cells

GSK, Epizyme enter partnership to discover, develop, and market epigenetic therapeutics

Study: Protein that plays a key role in some antioxidant therapies can promote atherosclerosis

Enobia Pharma completes ENB-0040 Phase II study in juveniles with hypophosphatasia

AMT enters agreement with Consortium for clinical development of novel gene therapy to treat Sanfilippo B

Two signaling molecules communicate across nerve cells to regulate electrical, chemical activity: Study

Study finds link between nonalcoholic fatty liver disease and stroke

Specific silicon microdevices may provide new way to screen metastatic breast cancer cells

Vaccines for alcoholism and cocaine addiction coming soon

Green tea may help in Alzheimer’s disease: Study

Cells that give rise to neurons maintain high levels of ROS

Research says regular intake of green tea can prevent Alzheimer's disease

Omeros receives exclusive license for new series of antifibrinolytic agents

Investigators receive two Alpha-1 Foundation grants for research on lung disorder

ReproCELL to enter collaborative iPS cell-derived hepatocytes R&D agreement with NIBIO

Anaphylatoxin C5a may be responsible for devastating effects of atherosclerosis

Critical tuning dial for controlling whole body energy

Blocking activation of delta-PKC enzyme could protect lungs from neutrophil-mediated damage

Biochemical Assays for Efficient Hit Prioritization After Screening eBook

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