Research News and Research

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AbbVie plans to advance ABT-494 to Phase 3 studies in rheumatoid arthritis

AbbVie, a global biopharmaceutical company, today announced that it will advance ABT-494, its internally developed investigational selective JAK1 inhibitor, to Phase 3 studies in rheumatoid arthritis. Following a thorough review of available data, AbbVie will not exercise its right to in-license the Galapagos JAK1 inhibitor, filgotinib.

25 Sep 2015

AbbVie reports positive results from ABT-494 Phase 2 clinical trials in patients with rheumatoid arthritis

AbbVie, a global biopharmaceutical company, today announced results from two Phase 2 clinical trials evaluating its investigational selective JAK1 inhibitor, ABT-494, in patients with inadequate response to either methotrexate or TNF inhibitors.

25 Sep 2015

Amgen gets positive CHMP opinions for Kyprolis (carfilzomib) and BLINCYTO (blinatumomab)

"We are pleased to receive positive CHMP opinions for Kyprolis and BLINCYTO as this is an important step in providing new treatment options for patients in Europe with rare forms of cancer," said Sean E. Harper, M.D., executive vice president of Research and Development at Amgen.

25 Sep 2015

UCSF researchers map genetic signature of unusual stem cells in the human brain

The human cerebral cortex contains 16 billion neurons, wired together into arcane, layered circuits responsible for everything from our ability to walk and talk to our sense of nostalgia and drive to dream of the future. In the course of human evolution, the cortex has expanded as much as 1,000-fold, but how this occurred is still a mystery to scientists.

25 Sep 2015

Researchers develop new blood test to diagnose coeliac disease

Diagnosis of coeliac disease requires a tissue sample from the small intestine, which can be extremely unpleasant. Researchers at the Faculty of Medicine have developed a blood test which provides a rapid, painless answer.

25 Sep 2015

New guideline on the use of prescription medications for treatment of opioid addiction

Medications play an important role in managing patients with opioid use disorders, but there are not enough physicians with the knowledge and ability to use these often-complex treatments.

25 Sep 2015

Kessler Foundation study may simplify cognitive assessment for MS in clinical settings

Kessler Foundation scientists found that the Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) predicted performance of activities of daily living using Actual Reality (AR). The article, "Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) and performance of everyday life tasks," was published in Multiple Sclerosis Journal.

25 Sep 2015

Proportion of young female anesthesiologists increases, but payment still lower than male peers

An increasing number of young female physicians are becoming anesthesiologists, but the pay of those women lags behind their male peers, even after accounting for differences such as hours worked and experience, according to a new RAND Corporation study.

25 Sep 2015

Researchers identify new biochemical pathway that could be a potential target for insulin control

In the final event leading to the development of Type 2 diabetes, the pancreas loses its ability to secrete insulin and clear glucose from the blood. Preventing this breakdown in insulin secretion is a key goal in the fight to reduce the burden of a disease that afflicts an estimated 29 million people in the United States.

25 Sep 2015

Delayed umbilical cord clamping may benefit extremely preterm infants

Clamping and cutting of the umbilical cord happens within 10 seconds after birth in most cases, in part so members of a medical team can more quickly begin caring for a newborn. But research from Nationwide Children's Hospital shows that waiting 30 to 45 seconds to clamp could have advantages for extremely preterm infants.

25 Sep 2015

Prevalence of frailty in older people varies by region and race

A large-scale survey of older Americans living at home or in assisted living settings found that 15 percent are frail, a diminished state that makes people more vulnerable to falls, chronic disease and disability, while another 45 percent are considered pre-frail, or at heightened risk of becoming physically diminished.

25 Sep 2015

Novel brain-computer interface technology allows paralyzed man to walk

Novel brain-computer interface technology created by University of California, Irvine researchers has allowed a paraplegic man to walk for a short distance.

25 Sep 2015

Valspar and NDSU announce scholarship and research program for students studying coatings, polymeric materials

The Valspar Corporation, a leading global manufacturer of paints and coatings, and North Dakota State University announced scholarship and research opportunities for students studying coatings and polymeric materials at NDSU.

25 Sep 2015

Weight loss and exercise improve ovulation in women with polycystic ovary syndrome

Weight loss and exercise improve ovulation in women who have polycystic ovary syndrome, a common hormone disorder that often causes infertility, according to a new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism.

25 Sep 2015

Fungi research may lead to cheaper anti-cancer drugs for humans

Cheaper anti-cancer drugs for humans might ultimately stem from a new study by University of Guelph scientists into a kind of microbial "bandage" that protects yew trees from disease-causing fungi.

25 Sep 2015

DNA nanostructures provide novel applications in molecular medicine

Researchers from Aalto University have published an article in the recent Trends in Biotechnology journal. The article discusses how DNA molecules can be assembled into tailored and complex nanostructures, and further, how these structures can find uses in therapeutics and bionanotechnological applications.

25 Sep 2015

Researchers develop chip-based instrument for reliable detection of Ebola virus

A team led by researchers at UC Santa Cruz has developed chip-based technology for reliable detection of Ebola virus and other viral pathogens. The system uses direct optical detection of viral molecules and can be integrated into a simple, portable instrument for use in field situations where rapid, accurate detection of Ebola infections is needed to control outbreaks.

25 Sep 2015

UCSF researchers develop molecular 'on switch' that allows control over the actions of T cells

UC San Francisco researchers have engineered a molecular "on switch" that allows tight control over the actions of T cells, immune system cells that have shown great potential as therapies for cancer. The innovation lays the groundwork for sharply reducing severe, sometimes deadly side effects that have been a significant hurdle to advancing T cell-based treatments.

25 Sep 2015

Research highlights potential new treatment strategy for degenerative diseases

St. Jude Children's Research Hospital scientists have discovered evidence of a mechanism at the heart of amyotrophic lateral sclerosis (ALS) and related degenerative diseases. The research appears in today's edition of the journal Cell and highlights a possible new treatment strategy for the devastating disorders.

25 Sep 2015

HIV cure research may shift from single-therapy development model to combination therapy trials

The next five years of HIV research should shift gears from the classic single-therapy development model to moving directly from in vitro studies to combination therapy trials, authors argue in a new paper published online today.

25 Sep 2015

Research News and Research

AbbVie plans to advance ABT-494 to Phase 3 studies in rheumatoid arthritis

AbbVie reports positive results from ABT-494 Phase 2 clinical trials in patients with rheumatoid arthritis

Amgen gets positive CHMP opinions for Kyprolis (carfilzomib) and BLINCYTO (blinatumomab)

UCSF researchers map genetic signature of unusual stem cells in the human brain

Researchers develop new blood test to diagnose coeliac disease

New guideline on the use of prescription medications for treatment of opioid addiction

Kessler Foundation study may simplify cognitive assessment for MS in clinical settings

Proportion of young female anesthesiologists increases, but payment still lower than male peers

Researchers identify new biochemical pathway that could be a potential target for insulin control

Delayed umbilical cord clamping may benefit extremely preterm infants

Prevalence of frailty in older people varies by region and race

Novel brain-computer interface technology allows paralyzed man to walk

Valspar and NDSU announce scholarship and research program for students studying coatings, polymeric materials

Weight loss and exercise improve ovulation in women with polycystic ovary syndrome

Fungi research may lead to cheaper anti-cancer drugs for humans

DNA nanostructures provide novel applications in molecular medicine

Researchers develop chip-based instrument for reliable detection of Ebola virus

UCSF researchers develop molecular 'on switch' that allows control over the actions of T cells

Research highlights potential new treatment strategy for degenerative diseases

HIV cure research may shift from single-therapy development model to combination therapy trials

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