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Artificial intelligence for predicting TMB-H colorectal cancer from histopathological characteristics

Biomarkers are important determinants of appropriate and effective therapeutic approaches for various diseases including cancer.

14 Jun 2021

Cell therapy improves outcomes for heart failure patients, clinical trial shows

A clinical trial conducted at the University of Louisville has shown for the first time that heart failure treatments using cells derived from the patient's own bone marrow and heart resulted in improved quality of life and reduced major adverse cardiac events for patients after one year.

14 Jun 2021

Leducq Foundation provides $7 million to support Cardiac Splicing as a Therapeutic Target project

Diverse messenger RNAs are produced in cells by “alternative splicing.” The Leducq Foundation is now supporting a transatlantic network dedicated to investigating this process in heart muscle cells and how changes in this process contribute to disease. Professor Michael Gotthardt of the MDC and Professor Leslie Leinwand of the University of Colorado Boulder are coordinating the project.

14 Jun 2021

Nanoparticle-based therapy alleviates pulmonary hypertension in mouse model of rare lung disease

The disease is so rare and complex that its acronym is hard to pronounce. But for infants unlucky enough to be born with this lung disease, the outcome is usually fatal.

14 Jun 2021

Kirigami-inspired stent to improve drug delivery for diseases that affect tubular organs

Diseases that affect tubular structures in the body, such as the gastrointestinal (GI) system, vasculature and airway, present a unique challenge for delivering local treatments.

14 Jun 2021

Intranasal monoclonal SARS-CoV-2 antibody therapy shows promise in preclinical trials

A new study, released as a preprint on the bioRxiv* server, presents a new monoclonal antibody (MAb) called DZIF-10c that powerfully neutralizes SARS-CoV-2, including the current variants of concern (VOCs). With high bioavailability in the lungs and wide distribution in the body, the antibody was able to prevent SARS-CoV-2 infection in mice after intranasal administration.

14 Jun 2021

UCSF launches new initiative to propel the development of living therapeutics

UC San Francisco is launching a new initiative to propel the development of living therapeutics - a category of treatments broadly defined as human and microbial living cells that are selected, modified, or engineered to treat or cure disease - and bring them quickly to patients.

14 Jun 2021

Enterprise Therapeutics doses first subjects in Phase I trial for novel cystic fibrosis therapy ETD001

Enterprise Therapeutics Ltd today announced it has successfully dosed the first subjects in a Phase 1 trial for its novel inhaled cystic fibrosis therapy, ETD001.

14 Jun 2021

Forkhead box O's potential therapeutic use in the treatment of COVID-19

In a recent study, Indian researchers from the Department of Biochemistry, University of Delhi, reviewed a possible vital coalition of FoxOs - the Forkhead Box O subfamily of protein transcription factors, with SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), the etiological agent of COVID-19 (coronavirus disease).

13 Jun 2021

An analysis links COVID-19 to brain microvascular injury and inflammation

The ongoing COVID-19 pandemic is caused by the severe acute respiratory syndrome-2 (SARS-CoV-2), an RNA virus that belongs to the family Coronaviridae. According to research, coronavirus disease 2019 (COVID-19) patients often suffer from neurological disorders like strokes, lost taste or smell, memory loss, confusion, and delirium.

13 Jun 2021

New radiopharmaceutical shows therapeutic efficacy in preclinical model of ovarian cancer

Preclinical trials of a new radiopharmaceutical to treat ovarian cancer have produced successful results, dramatically limiting tumor growth and decreasing tumor mass.

11 Jun 2021

Study shows feasibility of using Olfactory Virtual Reality to address anxiety, pain and stress

Findings from a study on the feasibility of addressing anxiety, pain and stress with Olfactory Virtual Reality (OVR) - a new form of VR that incorporates the sense of smell into its augmented reality - paint a clearer picture for clinical psychiatrists about how it could be used to safely and effectively help mental health and mood disorders.

11 Jun 2021

Study identifies mechanisms by which COVID-19 can lead to Alzheimer's disease-like dementia

A new Cleveland Clinic-led study has identified mechanisms by which COVID-19 can lead to Alzheimer's disease-like dementia.

11 Jun 2021

Metformin prevents pulmonary or lung inflammation in animals infected with SARS-CoV-2

Metformin is a widely prescribed blood sugar-lowering drug. It is often used as an early therapy (in combination with diet and lifestyle changes) for type 2 diabetes, which afflicts more than 34 million Americans.

11 Jun 2021

Study: cis P-tau is an early marker of vascular dementia, Alzheimer's disease

Researchers remain perplexed as to what causes dementia and how to treat and reverse the cognitive decline seen in patients.

11 Jun 2021

Ketogenic metabolic therapy could work synergistically with IDH1-mutant glioblastoma

A British man who rejected the standard of care to treat his brain cancer has lived with the typically fatal glioblastoma tumor growing very slowly after adopting a ketogenic diet, providing a case study that researchers say reflects the benefits of using the body's own metabolism to fight this particularly aggressive cancer instead of chemo and radiation therapy.

11 Jun 2021

AMP’s new consensus can promote standardization of PGx gene/allele testing, improve patient care

The Association for Molecular Pathology (AMP), the premier global, molecular diagnostic professional society, today published consensus recommendations to aid in the design and validation of clinical CYP2D6 assays, promote standardization of testing across different laboratories and improve patient care

11 Jun 2021

Therapy News and Research

Artificial intelligence for predicting TMB-H colorectal cancer from histopathological characteristics

Cell therapy improves outcomes for heart failure patients, clinical trial shows

Leducq Foundation provides $7 million to support Cardiac Splicing as a Therapeutic Target project

Nanoparticle-based therapy alleviates pulmonary hypertension in mouse model of rare lung disease

Kirigami-inspired stent to improve drug delivery for diseases that affect tubular organs

Intranasal monoclonal SARS-CoV-2 antibody therapy shows promise in preclinical trials

UCSF launches new initiative to propel the development of living therapeutics

Enterprise Therapeutics doses first subjects in Phase I trial for novel cystic fibrosis therapy ETD001

Forkhead box O's potential therapeutic use in the treatment of COVID-19

An analysis links COVID-19 to brain microvascular injury and inflammation

New radiopharmaceutical shows therapeutic efficacy in preclinical model of ovarian cancer

Study shows feasibility of using Olfactory Virtual Reality to address anxiety, pain and stress

Study identifies mechanisms by which COVID-19 can lead to Alzheimer's disease-like dementia

Metformin prevents pulmonary or lung inflammation in animals infected with SARS-CoV-2

Study: cis P-tau is an early marker of vascular dementia, Alzheimer's disease

Ketogenic metabolic therapy could work synergistically with IDH1-mutant glioblastoma

AMP’s new consensus can promote standardization of PGx gene/allele testing, improve patient care

Study provides treatment options for children with average risk medulloblastoma

Macrophages can aid tumor growth by distracting cancer-killing CD8+ T cells

Discovery suggests new pathways for safeguarding the immune system’s ability to fight cancer

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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