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Protein complex structure that plays an important role in regulating circadian rhythm identified

Structural biologists have made important progress towards better understanding the functioning of the circadian clock. The circadian or inner clock coordinates the sleep-wake rhythm and many other body processes that regulate, for example, metabolism, blood pressure, and the immune system.

31 May 2014

New research shows how misfolded proteins are precisely selected for degradation

It's almost axiomatic that misfolded proteins compromise how cells normally function and cause debilitating human disease, but how these proteins are detected and degraded within the body is not well understood.

30 May 2014

New nanoscale structures capable of introducing "cocktail" of multiple drugs into cancer cells

Biomedical engineering researchers have developed daisy-shaped, nanoscale structures that are made predominantly of anti-cancer drugs and are capable of introducing a "cocktail" of multiple drugs into cancer cells.

29 May 2014

Study detects hormone receptor's key role in normal organ development and function

A discovery by UC Irvine endocrinologists about the importance of cell surface receptors for estrogen has the potential to change how researchers view the hormone's role in normal organ development and function.

28 May 2014

TUSM scientists receive $11.5M grant to develop innovative treatments for heart failure

Innovative treatments for heart failure are lacking, leaving the nearly six million Americans who suffer from the condition with little hope for a cure.

23 May 2014

Dolutegravir drug offers added benefit in HIV patients

Dolutegravir has been approved since January 2014 in combination with other antiretroviral drugs for the treatment of human immunodeficiency virus (HIV) infected adults and adolescents above 12 years of age.

22 May 2014

Circadian disruption during chemotherapy linked to greater fatigue and body weight loss, says study

The circadian system, better known as our biological clock, is responsible for coordinating all the processes that take place in our organism.

21 May 2014

DNA-directed RNA interference and hepatitis C: an interview with Carl Stubbings, Chief Business Officer, Benitec Biopharma

RNA interference (RNAi) is a naturally occurring process, which cells can use to silence, or ‘turn off’ unwanted genes.

From Quest Diagnostics 19 May 2014

St. Jude analysis reveals how protein p53 triggers cancer cells to commit suicide

St. Jude Children's Research Hospital scientists have mapped the structural details of how p53 attaches to its regulatory protein, called BCL-xL, in the cell.

16 May 2014

Shark antibodies reveal evolutionary principles of immunoglobulins

Custom-tailored antibodies are regarded as promising weapons against a multitude of serious illnesses. Since they can accurately recognize specific structures on the surface of viruses, bacteria or cancer cells, they are already being deployed successfully in cancer diagnostics and therapy, as well as against numerous other diseases. The stability of the sensitive antibodies is a decisive factor in every step, from production and storage to therapeutic application.

15 May 2014

Researchers identify certain neurons responsible for behavioral decisions in rats

A new paper published by OIST's Neurobiology Research Unit identifies some of the neurons responsible for behavioral decisions in rats. Using a technique that employs light to control nerve cell activity, researchers in Professor Jeff Wickens' Unit inactivated a region of the brain and showed that it caused the rats to behave more flexibly while trying to get a reward.

15 May 2014

UofL institute and physician-director receive 2 MediStar awards

An institute at the University of Louisville and the physician-director of UofL's James Graham Brown Cancer Center won two MediStar awards presented May 13 at the Hyatt Regency Louisville.

15 May 2014

Researchers develop new high-tech device for transferring DNA into cells

The ability to transfer a gene or DNA sequence from one animal into the genome of another plays a critical role in a wide range of medical research-including cancer, Alzheimer's disease, and diabetes.

14 May 2014

Scientists find protein that controls DNA organization during sperm development

Infertility is generally thought of as a woman's problem. In fact, more than 3 million men across America also experience it.

13 May 2014

Researchers identify new molecular circuit that controls longevity in yeast and complex organisms

Ancient philosophers looked to alchemy for clues to life everlasting. Today, researchers look to their yeast.

9 May 2014

FABP5 protein enhances cognitive function

Case Western Reserve researchers have discovered that a protein previously implicated in disease plays such a positive role in learning and memory that it may someday contribute to cures of cognitive impairments.

5 May 2014

Researchers create tiny, biodegradable nanoparticles that carry DNA to brain cancer cells

Working together, Johns Hopkins biomedical engineers and neurosurgeons report that they have created tiny, biodegradable “nanoparticles” able to carry DNA to brain cancer cells in mice.

30 Apr 2014

Virginia Tech scientist receives grant to develop technique to detect subcellular location of protein

Virginia Tech chemical engineer Chang Lu and his colleagues have used a National Science Foundation grant to develop a technique to detect subcellular location of a protein.

26 Apr 2014

Johns Hopkins research may help manage the disruptive effects experienced by shift workers

Johns Hopkins researchers report that they have identified a protein essential to the formation of the tiny brain region in mice that coordinates sleep-wake cycles and other so-called circadian rhythms.

26 Apr 2014

Study finds role of oligomers in development of Parkinson's disease

Researchers at Aarhus University, Denmark, have drawn up the most detailed 'image of the enemy' to date of one of the body's most important players in the development of Parkinson's disease.

26 Apr 2014

Cell Nucleus News and Research

Protein complex structure that plays an important role in regulating circadian rhythm identified

New research shows how misfolded proteins are precisely selected for degradation

New nanoscale structures capable of introducing "cocktail" of multiple drugs into cancer cells

Study detects hormone receptor's key role in normal organ development and function

TUSM scientists receive $11.5M grant to develop innovative treatments for heart failure

Dolutegravir drug offers added benefit in HIV patients

Circadian disruption during chemotherapy linked to greater fatigue and body weight loss, says study

DNA-directed RNA interference and hepatitis C: an interview with Carl Stubbings, Chief Business Officer, Benitec Biopharma

St. Jude analysis reveals how protein p53 triggers cancer cells to commit suicide

Shark antibodies reveal evolutionary principles of immunoglobulins

Researchers identify certain neurons responsible for behavioral decisions in rats

UofL institute and physician-director receive 2 MediStar awards

Researchers develop new high-tech device for transferring DNA into cells

Scientists find protein that controls DNA organization during sperm development

Researchers identify new molecular circuit that controls longevity in yeast and complex organisms

FABP5 protein enhances cognitive function

Researchers create tiny, biodegradable nanoparticles that carry DNA to brain cancer cells

Virginia Tech scientist receives grant to develop technique to detect subcellular location of protein

Johns Hopkins research may help manage the disruptive effects experienced by shift workers

Study finds role of oligomers in development of Parkinson's disease

Event Guide: 3rd Annual TRP Supply Chain & Manufacturing Summit eBook

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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