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U-M leads multi-university partnership that aims to predict cognitive fatigue in individuals

Researchers at the University of Michigan are leading a multi-university partnership that aims to understand and predict cognitive fatigue in individuals.

13 Dec 2022

CRISPR/Cas9-engineered avatar mouse model of rare disease paves the way for targeted therapy

An international research team led by Dr Ana Guadaño at the Alberto Sols Biomedical Research Institute (IIBM, a combined CSIC-UAM center) and involving the Complutense University of Madrid (UCM), used CRISPR gene editing techniques to incorporate into the mice a mutation of the MCT8 protein responsible for transporting thyroid hormones to the interior of the cell.

12 Dec 2022

People with Alzheimer’s and Down syndrome may benefit from participating in Alzheimer’s clinical trials

Amyloid plaques — protein clumps that are one of the hallmarks of Alzheimer's disease—occur at roughly the same level in the brains of people with Down syndrome who have Alzheimer's as they do in people with forms of hereditary, early-onset Alzheimer's, according to research funded by the National Institutes of Health.

12 Dec 2022

Signaling pathway within brain cells regulates sleep

A good night's sleep can work wonders for both mind and body. But what is it that determines how much we need to sleep, and what can cause us to sleep more deeply?

12 Dec 2022

Severe COVID-19 causes aging-like changes in the human brain

Severe COVID-19 triggers aging-like changes in the brain's frontal cortex region that results in cognitive deficits.

11 Dec 2022

New study details the neuronal response to excessive aged-related iron accumulation

Iron (Fe) accumulates in the brain cortex with aging. A plethora of studies indicate that progressive iron accumulation in the substantia nigra (SN) in the aged human brain is a major risk factor for Parkinson's disease (PD) and other neurodegenerative diseases, but not everyone.

6 Dec 2022

Laser light therapy effective in improving working memory

Laser light therapy has been shown to be effective in improving short term memory in a study published in Science Advances.

2 Dec 2022

Study shows how ketamine administration starkly changes neuronal activity patterns in the brain

Ketamine, an established anesthetic and increasingly popular antidepressant, dramatically reorganizes activity in the brain, as if a switch had been flipped on its active circuits, according to a new study by Penn Medicine researchers.

1 Dec 2022

Research shows promising results using neurotechnological approaches to treat youth depression

New research shows promising results using neurotechnological approaches to treat depression in youth. The research, led by Simon Fraser University (SFU) professor Faranak Farzan, is published in the Journal of Affective Disorders Reports.

1 Dec 2022

Pandemic-related stressors have physically altered teens’ brains, study shows

A new study from Stanford University suggests that pandemic-related stressors have physically altered adolescents' brains, making their brain structures appear several years older than the brains of comparable peers before the pandemic.

1 Dec 2022

New transcranial magnetic stimulation array can help stimulate deeper tissue within the brain

As a noninvasive neuromodulation method, transcranial magnetic stimulation (TMS) shows great potential to treat a range of mental and psychiatric diseases, including major depression.

29 Nov 2022

Study reveals a promising therapeutic target for Alzheimer's disease

In a recent search for gene variants associated with Alzheimer's disease (AD), several affected families showed a mutation in an enzyme called protein kinase C-alpha (PKCα). Family members with this mutation had AD; those without the mutation did not.

28 Nov 2022