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SARS-CoV-2 ORF8 protein binds to dendritic cells and induces a hyper-inflammatory cytokine storm

In a recent study posted to the bioRxiv* pre-print server, researchers examined how the interaction of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) open reading frame 8 (ORF8) protein with host dendritic cells (DCs) induced cytokine storm.

8 Jun 2022

Pregnant people in Sub-Saharan Africa are at higher risk of complications and death from COVID-19

Pregnant people who are hospitalized with COVID-19 in Sub-Saharan Africa are dying at a rate far greater than pregnant people without COVID-19 and non-pregnant people with COVID-19, according to a new multicenter study encompassing six African countries.

8 Jun 2022

People with HIV are at greater risk of breakthrough COVID-19 infections after vaccination

People with HIV have a higher rate of breakthrough COVID-19 infections after vaccination, compared to people without HIV, according to findings from a study led by researchers at the Johns Hopkins Bloomberg School of Public Health.

7 Jun 2022

Monkeypox virus transmission via sexual contact

A new study discusses the transmission of monkeypox through sexual contact.

6 Jun 2022

Details of SARS-CoV-2 seroprevalence surveys supported by the US CDC

Researchers reviewed and analyzed data from SARS-CoV-2 serosurveys supported by the United States Centers for Disease Prevention and Control in the low- and middle-income countries.

6 Jun 2022

Pandemic-era changes to prescribing opioid use disorder treatment improved treatment outcomes

Pandemic-era changes to prescribing guidelines for the lifesaving drug buprenorphine led to improved treatment outcomes for patients with opioid use disorder in Philadelphia, according to a recently published study in the journal Drug and Alcohol Dependence Reports from researchers at Drexel University's Dornsife School of Public Health.

3 Jun 2022

Epidemiology and the public health response of monkeypox

Monkeypox is a zoonotic disease, i.e. it can be transmitted between animals and humans via direct or indirect contacts.

3 Jun 2022

Highly sensitive blood test could give doctors a new tool to quickly identify and treat tuberculosis

Researchers at Tulane University School of Medicine have developed a new highly sensitive blood test for tuberculosis (TB) that screens for DNA fragments of the Mycobacterium tuberculosis bacteria that causes the deadly disease.

1 Jun 2022

Combination bNAb therapy may offer a future alternative to daily ART for people living with HIV

Individuals with HIV who began taking antiretroviral therapy (ART) in the early stages of infection achieved a lengthy period of HIV suppression without ART after receiving two broadly neutralizing anti-HIV antibodies (bNAbs), according to a small study published today in the journal Nature.

1 Jun 2022

Common experiences of stigma in people living with Long Covid

The vast majority of individuals, both with and without a long COVID diagnosis, have experienced some form of stigma.

1 Jun 2022

HIV research enables knowledge transfer for improved COVID-19 response

Global virology and immunology networks that were originally developed for HIV vaccine research were rapidly adapted to study COVID-19.

31 May 2022

Sarbecovirus open reading frame 7a suppresses major histocompatibility complex-I antigen presentation

Researchers demonstrated the sarbecovirus open reading frame 7a (ORF7a)-induced hindrance of the antigen presentation by the major histocompatibility complex class I (MHC-I) in hosts.

30 May 2022

After SARS-CoV-2 infection, anti-chemokine antibodies correlate with better outcomes

A recent study posted to the bioRxiv* preprint server illustrated that specific chemokine antibodies aid in recognizing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) convalescent individuals with a desirable disease course.

26 May 2022

UCLA researchers discover key molecular mechanism behind memory linking

Our brains rarely record single memories - instead, they store memories into groups so that the recollection of one significant memory triggers the recall of others connected by time.

25 May 2022

STIs could be prevented with a dose of doxycycline after unprotected sex

A significant proportion of bacterial sexually transmitted infections (STIs) - gonorrhea, chlamydia or syphilis - were prevented with a dose of doxycycline after unprotected sex, according to preliminary results of a clinical trial that closed early because it was very effective for men who have sex with men and transgender women who are living with HIV or are taking HIV pre-exposure prophylaxis (PrEP).

25 May 2022

The effectiveness of sotrovimab vs. molnupiravir in preventing severe COVID-19 outcomes in non-hospitalized high-risk COVID-19 adult patients

Researchers compared the efficacy of sotrovimab and molnupiravir in preventing severe COVID-19 outcomes among non-hospitalized and high-risk COVID-19 patients across England.

25 May 2022

The Blackfeet nation’s plight underscores the fentanyl crisis on reservations

As the pandemic was setting in during summer 2020, Justin Lee Littledog called his mom to tell her he was moving from Texas back home to the Blackfeet Indian Reservation in Montana with his girlfriend, stepson, and son.

25 May 2022

Study reports on the first instances of in-hospital, household transmission of monkeypox

A new retrospective study of seven patients diagnosed with monkeypox in the UK between 2018 and 2021, suggests that some antiviral medications might have the potential to shorten symptoms and reduce the amount of time a patient is contagious.

24 May 2022

Hamster contact exposure challenge model assesses protection conferred by SARS-CoV-2 vaccination or prior infection against reinfection

Researchers assessed the neutralization efficacy of a saRNA vaccine targeting SARS-CoV-2 S protein against reinfection among hamsters with prior vaccination or infection.

24 May 2022

Study suggests that recall of B cell memory may depend on relative locations of prime and boost immunization

A new study investigated whether a specific population of local Bmem cells in the proximal LNs produce secondary GC responses that are different from those at distal sites and if the location in humoral immunity is relevant only to nonlymphoid tissues.

23 May 2022

HIV 1 News and Research

SARS-CoV-2 ORF8 protein binds to dendritic cells and induces a hyper-inflammatory cytokine storm

Pregnant people in Sub-Saharan Africa are at higher risk of complications and death from COVID-19

People with HIV are at greater risk of breakthrough COVID-19 infections after vaccination

Monkeypox virus transmission via sexual contact

Details of SARS-CoV-2 seroprevalence surveys supported by the US CDC

Pandemic-era changes to prescribing opioid use disorder treatment improved treatment outcomes

Epidemiology and the public health response of monkeypox

Highly sensitive blood test could give doctors a new tool to quickly identify and treat tuberculosis

Combination bNAb therapy may offer a future alternative to daily ART for people living with HIV

Common experiences of stigma in people living with Long Covid

HIV research enables knowledge transfer for improved COVID-19 response

Sarbecovirus open reading frame 7a suppresses major histocompatibility complex-I antigen presentation

After SARS-CoV-2 infection, anti-chemokine antibodies correlate with better outcomes

UCLA researchers discover key molecular mechanism behind memory linking

STIs could be prevented with a dose of doxycycline after unprotected sex

The effectiveness of sotrovimab vs. molnupiravir in preventing severe COVID-19 outcomes in non-hospitalized high-risk COVID-19 adult patients

The Blackfeet nation’s plight underscores the fentanyl crisis on reservations

Study reports on the first instances of in-hospital, household transmission of monkeypox

Hamster contact exposure challenge model assesses protection conferred by SARS-CoV-2 vaccination or prior infection against reinfection

Study suggests that recall of B cell memory may depend on relative locations of prime and boost immunization

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