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Research identifies potential treatment target for infantile spasms syndrome

New research from Tufts University School of Medicine and the Graduate School of Biomedical Sciences suggests that the timing of the death of certain inhibitory neurons in the brain shortly after birth may be at least partly to blame for infantile spasms syndrome (ISS), a rare but devastating form of epilepsy that develops most frequently between four and eight months of age but can emerge within weeks of birth until ages 4 or 5.

21 Feb 2023

Fetal cell program appears to protect against acute myeloid leukemia

During the fetal stage, a number of so-called cell programs run that are vital to the development of the fetus.

21 Feb 2023

Study indicates that macrophages that reside in the lymph nodes contribute to the initial Zika virus spread

Researchers mapped Zika virus infections in the lymph nodes to determine how the Zika virus enters from different points in the skin and disseminates through the body.

20 Feb 2023

UTHSC researchers secure $308,000 grant from Department of Defense for dementia study

Repeated traumatic brain injuries (TBI) in soldiers and military personnel can cause behavioral, neurological, and cognitive effects and lead to dementia.

19 Feb 2023

Researchers use the drug fasudil to reverse two key symptoms of schizophrenia

A team from Nagoya University in Japan used the drug fasudil to reverse two common symptoms associated with schizophrenia: reduced density of pyramidal neurons and cognitive dysfunction associated with methamphetamine treatment.

17 Feb 2023

Small molecule inhibitor reverses malignant hyper-editing by an inflammation-induced protein isoform

Researchers at University of California San Diego School of Medicine, Sanford Stem Cell Institute and Moores Cancer Center report that a late-stage, pre-clinical small molecule inhibitor, called rebecsinib, reverses malignant hyper-editing by an inflammation-induced protein isoform, known as ADAR1 p150.

16 Feb 2023

Similar genes may lead to different patterns of fat distribution in women

Obesity causes many health problems and worsens several chronic illnesses, including type 2 diabetes and cardiovascular disease, however, some obese people are more susceptible to complications than others.

16 Feb 2023

Repurposing or improving drugs for spinocerebellar ataxia type 5

A team of researchers has developed a new method to screen FDA-approved drugs to determine if they could be repurposed or improved to help patients with a rare, debilitating disease of the nervous system.

16 Feb 2023

First successful correction of limb length in mouse model of autosomal dominant Robinow Syndrome

Robinow Syndrome is the best known of a set of genetic disorders that affect the growth and development of the skeletal system.

15 Feb 2023

Migraine drug could be a potential treatment for acute kidney injury

The drug lasmiditan, which is used to treat migraines, shows promise as a possible treatment for acute kidney injury, according to a new study from the University of Arizona.

15 Feb 2023

B lymphocytes play a pivotal role in promoting an emergent response during infection

An SOS signals a call for immediate action during an emergency to request a need for protection. The immune system, a network of defense mechanisms, enhances protection to recover the body's internal stability.

15 Feb 2023

New mouse model demonstrates clear differences in virulence among mpox virus clades

Scientists from the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health have removed a major roadblock to better understanding of mpox (formerly, monkeypox).

14 Feb 2023

New research could help explain how sense of smell is impacted in individuals with autism

New research from New York Institute of Technology College of Osteopathic Medicine could help explain how the sense of smell is impacted in individuals with autism.

14 Feb 2023

The immunogenicity of two leading malaria vaccine candidates delivered as mRNA-LNP vaccines

Researchers evaluated the immunogenicity of two vaccine candidates, Pfs25 and PfCSP, based on the mRNA-lipid nanoparticle (LNP) platform.

13 Feb 2023

Study suggests SARS-CoV-2 is likely to only infect placental mammals

Researchers perform ontological and taxonomical analysis of human coronavirus hosts.

9 Feb 2023

Researchers find possible genetic basis and mouse model for nonalcoholic steatohepatitis

A mutant or damaged gene may be a cause of a severe, mysterious form of nonalcoholic fatty liver disease, University of Illinois Urbana-Champaign researchers have found.

9 Feb 2023

Inhalable powder could protect lungs and airways from viral invasion

Researchers have developed an inhalable powder that could protect lungs and airways from viral invasion by reinforcing the body's own mucosal layer.

9 Feb 2023

Researchers find a way to block anaphylaxis caused by peanut allergies

Researchers from Indiana University School of Medicine have found a way to block anaphylaxis caused by peanut allergies.

9 Feb 2023

New strategies to beat rare tumors of the adrenal gland

Only one in 100,000 people suffer from a pheochromocytoma, a tumor of the adrenal gland. If the tumor has already metastasized, a radioactive compound can be used to detect malignant cells that have spread to other parts of the body, and to irradiate them from the inside.

9 Feb 2023

High-fat diet allows the immune system to eliminate a parasitic worm from the intestine

Scientists have discovered that a high-fat diet allows the immune system to eliminate a parasitic worm which is a major cause of death and illness in the developing world.

7 Feb 2023

Mouse Model News and Research

Research identifies potential treatment target for infantile spasms syndrome

Fetal cell program appears to protect against acute myeloid leukemia

Study indicates that macrophages that reside in the lymph nodes contribute to the initial Zika virus spread

UTHSC researchers secure $308,000 grant from Department of Defense for dementia study

Researchers use the drug fasudil to reverse two key symptoms of schizophrenia

Small molecule inhibitor reverses malignant hyper-editing by an inflammation-induced protein isoform

Similar genes may lead to different patterns of fat distribution in women

Repurposing or improving drugs for spinocerebellar ataxia type 5

First successful correction of limb length in mouse model of autosomal dominant Robinow Syndrome

Migraine drug could be a potential treatment for acute kidney injury

B lymphocytes play a pivotal role in promoting an emergent response during infection

New mouse model demonstrates clear differences in virulence among mpox virus clades

New research could help explain how sense of smell is impacted in individuals with autism

The immunogenicity of two leading malaria vaccine candidates delivered as mRNA-LNP vaccines

Study suggests SARS-CoV-2 is likely to only infect placental mammals

Researchers find possible genetic basis and mouse model for nonalcoholic steatohepatitis

Inhalable powder could protect lungs and airways from viral invasion

Researchers find a way to block anaphylaxis caused by peanut allergies

New strategies to beat rare tumors of the adrenal gland

High-fat diet allows the immune system to eliminate a parasitic worm from the intestine

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