Signaling Pathway News and Research

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'Hijacked' cell response to stress reveals potential therapeutic targets for leukemia

A signaling pathway that helps promote normal cell growth worsens a form of leukemia by taking control of another pathway better known for protecting cells from biological stress, a new study shows.

24 Jul 2018

Homogenous BTK occupancy assay used in tirabrutinib clinical studies

In a new SLAS Discovery article, Helen Yu and a team of researchers at Gilead Sciences, Inc. present a time-resolved fluorescence resonance energy transfer-based Bruton's tyrosine kinase occupancy assay that can measure target engagement in peripheral blood mononuclear cells and in lymph-node and bone-marrow samples.

17 Jul 2018

3D modeling of drug resistance could lead to more effective cancer treatment

The National Institutes of Health is funding the research of a University of Akron scientist that could lead to more effective cancer treatment.

16 Jul 2018

Researchers describe key role of enzyme in regulating immune response against Chagas disease parasite

In an article published recently in the journal Nature Communications, researchers affiliated with the University of São Paulo in Brazil describe the central role played by an enzyme called phosphatidylinositol 3-kinase gamma in regulating the immune response against Trypanosoma cruzi, the protozoan parasite that causes Chagas disease.

16 Jul 2018

UM researchers awarded NIH funding to study bacterium that causes Lyme disease

University of Montana researchers Dan Drecktrah and Scott Samuels were recently awarded $449,998 from the National Institutes of Health for the first year of a five-year project to study the bacterium that causes Lyme disease.

11 Jul 2018

Researchers elucidate role of mutations in deadly brain cancer

Researchers from the University of North Carolina Lineberger Comprehensive Cancer Center have discovered how different mutations in a specific gene help drive glioblastoma, the most lethal form of brain cancer.

11 Jul 2018

Study elucidates pathophysiology of systemic lupus erythematosus

Osaka University researchers elucidated the pathophysiology of systemic lupus erythematosus, an autoimmune disorder that causes inflammation and tissue damage.

11 Jul 2018

Researchers find ATM protein that can trigger production of antioxidants

One reason we're supposed to eat a variety of colorful fruits and vegetables is because they contain nutritious compounds called antioxidants.

11 Jul 2018

Researchers discover mechanism that shuts down cell-to-cell communications pathway

Cellular functions rely on several communications networks that allow cells to rapidly respond to signals affecting the organism.

10 Jul 2018

U.S. researchers recommend development of anti-cancer drugs based on mechanism of Namodenoson

Can-Fite BioPharma Ltd., a biotechnology company advancing a pipeline of proprietary small molecule drugs that address cancer, liver and inflammatory diseases, today announced that U.S. researchers published scientific findings recommending development of anti-Liver Cancer Drugs based on a mechanism of action utilized by Namodenoson.

2 Jul 2018

Researchers find link between mutations in TRAF7 gene and multisystem disorder

A group of seven patients presenting with a similar disorder of unknown origin now know of a possible genetic root of their condition.

28 Jun 2018

Researchers show how mutant CALR protein triggers cancer

Researchers at Juntendo University report in the journal Leukemia how mutants of the protein calreticulin lead to molecular mechanisms triggering myeloproliferative neoplasms, which can cause cancer. The findings may lead to the development of novel therapies for certain types of blood cancer.

28 Jun 2018

Study links molecular changes in the brain to key behaviors in addiction

Changes in a brain signaling system contribute to the development of alcohol addiction-like behaviors in rats, according to a new study led by researchers at Linköping University, Sweden.

25 Jun 2018

New studies on molecular and cellular proteomics

Researchers at the Karolinska Institute were using a proteomic screen to determine the mechanism by which cancer drug candidates killed cells when they realized a potential flaw in the standard experimental design.

21 Jun 2018

Research sheds light on pathways involved in transmitting itch sensations from skin to brain

Researchers from North Carolina State University have pinpointed a particular neuropeptide associated with transmitting itch signals in mice with atopic dermatitis.

14 Jun 2018

Study opens new potential avenue for treating ovarian cancer

Researchers at Houston Methodist Research Institute and The University of Texas MD Anderson Cancer Center have found a prescription drug, Calcitriol, approved by the Food and Drug Administration for the treatment of calcium deficiency and kidney diseases, may increase the likelihood of surviving ovarian cancer.

14 Jun 2018