Bone Marrow News and Research

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Bone Marrow is the soft, sponge-like tissue in the center of most bones. It produces white blood cells, red blood cells, and platelets.

Allowing low-level CMV infection may boost immunity in stem cell transplant recipients

Patients who develop cytomegalovirus infections after allogeneic stem cell transplantation may be able to develop an immunity against the virus, strengthen their immune system and reduce reliance on strong antiviral medications, a team of cellular-therapy specialists from Roswell Park Comprehensive Cancer Center has found.

25 Aug 2020

New York Blood Center receives $15.6 million NIH grant for sickle cell transfusion research

The National Heart, Lung and Blood Institute of the National Institutes of Health has awarded a five-year grant of $15.6 million to Karina Yazdanbakhsh, PhD, of New York Blood Center’s Lindsley F. Kimball Research Institute, to lead a collaborative research program studying the consequences of transfusions in patients with sickle cell disease and developing strategies to optimize transfusion management for this patient group.

21 Aug 2020

Microbial diversity can improve treatment for cancer patients

Physicians at City of Hope, working in collaboration with scientists at Translational Genomics Research Institute (TGen), have found that greater gut microbial diversity in patients with metastatic kidney cancer is associated with better treatment outcomes on Food and Drug Administration-approved immunotherapy regimens.

19 Aug 2020

Antibody and cellular immunity in severe vs. mild COVID-19

Now, a new study published in the journal Signal Transduction and Targeted Therapy in August 2020 shows that while humoral and T-cell immune responses are more robust in severe infection, the disease activates memory T cells as part of the adaptive immune system in COVID-19 patients irrespective of disease severity.

18 Aug 2020

RNA-based therapeutic approach holds promise as potential cure for hereditary diseases

ETH Zurich scientists have developed an RNA molecule that can be used in bone marrow cells to correct genetic errors that affect protein production.

18 Aug 2020

Gene editing approach removes oral herpes

Infectious disease researchers at Fred Hutchinson Cancer Research Center have used a gene editing approach to remove latent herpes simplex virus 1, or HSV-1, also known as oral herpes.

18 Aug 2020

Scientists identify genetic link to predict treatment response in patients with aggressive blood cancer

A Singapore team led by clinician-scientists and researchers from the National Cancer Centre Singapore (NCCS) discovered a genetic link to better predict treatment response for relapsed/refractory patients with natural- killer T-cell lymphoma (NKTCL), a highly aggressive form of blood cancer.

13 Aug 2020

Researchers explore association of malaria, HIV with anemia during pregnancy

Pregnant women from sub-Saharan Africa with malaria and human immunodeficiency virus (HIV) have a higher prevalence of anemia than pregnant women without infections according to Penn State College of Medicine researchers.

12 Aug 2020

Researchers develop an integrated technology for seeing into cells at greater detail

Invading cells' private space - prying into their internal functions, decisions and communications - could be a powerful tool that may help researchers develop new immunotherapy treatment for cancer.

12 Aug 2020

New techniques help replace malfunctioning microglia associated with neurological disorders

Researchers at Fudan University in Shanghai, China have developed three different techniques that successfully replace almost all malfunctioning microglia - each technique with its own advantage in application

12 Aug 2020

Study may help optimize materials used in implants, enhance their safety

Using highly complex analytical techniques, a group of researchers from Charité - Universitätsmedizin Berlin were able to observe in detail how different metals are released from joint implants and accumulate in the surrounding bone tissue.

11 Aug 2020

First clinical trial could become an effective way to deliver chemotherapy to abdominal cancer patients

City of Hope surgical researchers are the first in the nation to open a clinical trial that could one day become an effective way to deliver chemotherapy to abdominal cancer patients who currently have very few treatment options.

11 Aug 2020

Nanomedicine-based strategy enhances anti-PD1 therapy to eradicate PTEN-negative GBM

A nanomedicine-based strategy for chemo-immunotherapy (CIT) of glioblastoma (GBM), which has the worst prognosis among brain tumors, was successfully developed.

7 Aug 2020

New alpha-radioimmunotherapy for multiple myeloma shows promise in preclinical study

A new alpha-radioimmunotherapy, 212Pb-anti-CD38, has proven effective in preventing tumor growth and increasing survival in multiple myeloma tumor-bearing mice, according to new research published in the July issue of the Journal of Nuclear Medicine. Given the long half-life, central production and worldwide distribution of 212Pb-anti-CD38, researchers have determined that the α-radioimmunotherapy is not only effective but also clinically feasible as a multiple myeloma treatment.

6 Aug 2020

Cats susceptible to and potential reservoirs for novel coronavirus

The study published on the preprint server bioRxiv in August 2020 shows that this is indeed taking place, with pet cats being infected and passing on the infection to contacts. It also offers the chance to see how the disease progresses in a susceptible host.

6 Aug 2020

Bisphosphonates may be safe and beneficial for osteoarthritis patients

Bisphosphonates (a class of drugs that prevent the loss of bone density and used to treat osteoporosis and similar diseases) appear to be safe and beneficial for osteoarthritis patients.

5 Aug 2020

Study identifies impact of gene mutations on severity of myelodysplastic syndrome

The Myelodysplastic Syndromes Group of Josep Carreras Leukaemia Research Institute, led by Dr. Francesc Solé, has participated in the first international study that confirms that having two mutated copies of the TP53 gene, as opposed to a single mutated copy, is associated with a worse prognosis in patients diagnosed with myelodysplastic syndrome (MDS).

4 Aug 2020

Bone Marrow News and Research

Further Reading

Allowing low-level CMV infection may boost immunity in stem cell transplant recipients

New York Blood Center receives $15.6 million NIH grant for sickle cell transfusion research

Microbial diversity can improve treatment for cancer patients

Antibody and cellular immunity in severe vs. mild COVID-19

RNA-based therapeutic approach holds promise as potential cure for hereditary diseases

Gene editing approach removes oral herpes

Scientists identify genetic link to predict treatment response in patients with aggressive blood cancer

Researchers explore association of malaria, HIV with anemia during pregnancy

Researchers develop an integrated technology for seeing into cells at greater detail

New techniques help replace malfunctioning microglia associated with neurological disorders

Study may help optimize materials used in implants, enhance their safety

First clinical trial could become an effective way to deliver chemotherapy to abdominal cancer patients

Nanomedicine-based strategy enhances anti-PD1 therapy to eradicate PTEN-negative GBM

New alpha-radioimmunotherapy for multiple myeloma shows promise in preclinical study

Cats susceptible to and potential reservoirs for novel coronavirus

Bisphosphonates may be safe and beneficial for osteoarthritis patients

Study identifies impact of gene mutations on severity of myelodysplastic syndrome

Researcher is exploring safer and more effective treatment for leukemia

Study sheds light on potential new treatment approach in AML patients

Researchers report a liquid biopsy for COVID-19

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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