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Why does convalescent plasma therapy for severe COVID-19 show mixed success?

A surprising new preprint, released on the medRxiv* server, suggests that the beneficial effects of convalescent plasma (CP) in this disease stem not only from the presence of neutralizing antibodies, but also the immunomodulatory effects of this plasma that shapes the host immune response.

15 Mar 2021

Neutralizing nanobodies effective against SARS-CoV-2 variants

Nanobodies have different mechanisms to neutralize viruses, and some target epitopes not accessible to monoclonal antibodies, making them an alternative for developing therapies for COVID-19.

15 Mar 2021

The boom in out-of-state telehealth threatens in-state providers

When the Hazelden Betty Ford Foundation began offering telehealth services in Montana in early February, the nation's largest nonprofit addiction treatment provider promised quality care for far-flung residents without their even having to leave home.

15 Mar 2021

Cognitive behavioral therapy can reduce dental anxiety in children

A pioneering study led by the University of Sheffield and Sheffield Teaching Hospitals will investigate whether Cognitive Behavioral Therapy (CBT) could help reduce the worryingly high number of children who are afraid of the dentist.

15 Mar 2021

Immuno-PET detects changes in different cancer receptors in response to targeted therapies

Immuno-positron emission tomography (PET) imaging can provide early insight into a tumor's response to targeted therapy, allowing physicians to select the most effective treatment for patients who have cancer.

13 Mar 2021

Cats with chronic kidney disease may help inform treatment for humans in future

The Wake Forest Institute for Regenerative Medicine is investigating how cats with chronic kidney disease could someday help inform treatment for humans.

13 Mar 2021

Otago researchers find how to treat heart disease in type-2 diabetics

University of Otago researchers have discovered one of the reasons why more than 50 per cent of people with type 2 diabetes die from heart disease.

12 Mar 2021

New approach could treat infertility caused by abnormal GnRH secretion

Reports suggest that at least 25% of ovarian disorders are due to dysfunction of the brain mechanism in the hypothalamus that controls the gonadotropin-releasing hormone (GnRH), which is a molecule that governs the reproductive function in men and women by regulating the release of a range of reproductive hormones into the body, particularly gonadotropins, from the pituitary gland, which is located underneath the brain.

12 Mar 2021

NCCN publishes new guidance for management of COVID-19 in cancer patients

The National Comprehensive Cancer Network--an alliance of leading cancer centers--has published new best practice recommendations for Management of COVID-19 Infection in Patients with Cancer.

11 Mar 2021

New biodegradable nanoprobes could help detect cancer more accurately

New Imperial-developed nanoprobes tested in zebrafish could help detect cancer more accurately and might aid diagnosis and therapy in the future.

11 Mar 2021

Studies reveal how kidney tumors' microenvironments change in response to immunotherapy

In the last two decades, immunotherapy has emerged as a leading treatment for advanced renal carcinoma cancer (more commonly known as kidney cancer).

11 Mar 2021

Delays in treatment at the hospital may have severe consequences on stroke recovery

For every 10-minute delay between arrival at the emergency room (ER) and starting stroke treatment, patients with severe strokes may lose eight weeks of healthy life, according to preliminary research to be presented at the American Stroke Association's International Stroke Conference 2021.

11 Mar 2021

NIAID awards $2.5 million in grants to support research on bacteriophage therapy

The National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, has awarded $2.5 million in grants to 12 institutes around the world to support research on bacteriophage therapy.

11 Mar 2021

Lithium chloride can alleviate radiation-induced oral mucositis and taste dysfunction

Oral mucositis and taste dysfunction (dysgeusia) occurs in nearly all patients receiving head and neck radiotherapy and tremendously affects the quality of life and treatment outcome.

11 Mar 2021

Novel CRISPR-based gene editor developed to correct mutations that cause genetic disorders

A team of researchers from the Agency for Science, Technology and Research's (A*STAR) Genome Institute of Singapore have developed a CRISPR-based gene editor, C-to-G Base Editor (CGBE), to correct mutations that cause genetic disorders.

11 Mar 2021

Healthy Diet Index facilitates the assessment of diet quality

The Healthy Diet Index developed by Finnish nutrition experts facilitates the assessment of diet quality. Its effectiveness was demonstrated in a recently published study.

11 Mar 2021

Pregnant women in Japan had higher levels of anxiety during COVID-19 pandemic

Pregnant women in Japan who responded to an online survey early in the COVID-19 pandemic demonstrated higher levels of anxiety compared to women undergoing fertility treatments and to pregnant women in Iran.

11 Mar 2021

New system may offer improved options for cancer treatment

Improved options for cancer treatment are on the way, thanks to a new system developed at Los Alamos National Laboratory for producing alpha-emitting medical radioisotopes intended to target and overpower diseased tissue while sparing the healthy tissue around it.

11 Mar 2021

Music-based interventions can improve stroke, Parkinson's disease

Music-based interventions have become a core ingredient of effective neurorehabilitation in the past 20 years thanks to the growing body of knowledge.

11 Mar 2021

Whole genome sequencing may guide blood cancer treatment

For certain blood cancers, such as acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS), deciding whether patients need an aggressive treatment typically hinges on a set of lab tests to identify genetic changes.

11 Mar 2021