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SARS-CoV-2 D614G variant enhances infectivity, replication and transmission

Researchers in the United States and Japan have conducted a study showing a common mutation in the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) - the agent that causes coronavirus disease 2019 (COVD-19) - enhances the infectivity, replication, and early transmission of the virus.

30 Sep 2020

Danish vs. Swedish data shows social interaction major risk factor for SARS-CoV-2 infection

A new study published on the preprint server medRxiv* in September 2020 compares the prevalence of antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Danish and Swedish healthcare workers, to conclude that “social interaction is one of the biggest risk factors for getting infected with SARS-CoV-2.”

30 Sep 2020

A TLR2 agonist reduces SARS-CoV-2 in upper respiratory tract of ferret model

In a recent bioRxiv* preprint paper, Professor Miles W. Carroll et al. study an agonist for reducing the SARS-CoV-2's viral load. They show that prophylactic intra-nasal administration of TLR2/6 (toll-like receptor) agonist, INNA-051, reduces viral RNA in the nose and throat, in a ferret model.

30 Sep 2020

Different triggers for Kawasaki disease suggest slightly different genetic susceptibilities

Researchers at University of California San Diego report that while Kawasaki disease (KD) occurs in clusters, the traits, and thus the triggers of the inflammatory disease vary among clusters. The findings are published in the September 2020 online issue of The Journal of Pediatrics.

30 Sep 2020

Researchers develop research model to understand the impact of coronavirus on lungs

Scientists at Boston University's National Emerging Infectious Diseases Laboratories (NEIDL) and the Center for Regenerative Medicine (CReM) joined forces to develop the most relevant research model possible for understanding how the coronavirus virus impacts the lungs, by engineering living, "breathing" human lung cells from stem cells for the task.

30 Sep 2020

Sleep apnea increases risk of severe COVID 19

Coronavirus disease (COVID-19) is a respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. A subset of COVID-19 patients face a severe form of the disease with hospitalization, respiratory failure, or death. Severe COVID-19 is primarily characterized by respiratory distress, and the common risk factors are older age, obesity, cardiovascular disease, diabetes, and poor lung function.

29 Sep 2020

College football crowds could impact COVID-19 spread

The observed increase in COVID-19 cases coinciding with the reopening of college campuses all over the US has drawn intense scientific attention. A recent paper, by Washington State University researchers, published on the preprint server medRxiv* in September 2020 reports that this threat is directly linked to the holding of in-person sporting events on these campuses.

29 Sep 2020

New graphical tool to identify potent neutralizing antibodies against SARS-CoV-2

A new study by researchers at the Indian Institute of Science and the University of Queensland and published on the preprint server medRxiv in September 2020 discusses using a novel tool to identify the most effective among currently known anti-SARS-CoV-2 NAbs.

29 Sep 2020

Australian scientists develop a nasal spray that could stop SARS-CoV-2 infection

The novel product, called INNA-051, is being developed by Ena Respiratory, and laboratory experiments have shown that it reduced viral replication by as much as 96 percent in the animal study. Spearheaded by Public Health England’s (PHE) Deputy Director, Professor Miles Carroll, the new study described the potential treatment and has been published in the open-source preprint server bioRxiv*.

29 Sep 2020

Case fatality rates for COVID-19 and health indicators

Researchers from Turkey and Switzerland collaborated to study the nation-specific case fatality rates for COVID-19 caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The pandemic has affected around 33.5 million people worldwide and killed over 1 million making it one of the largest global health crises in recent memory.

29 Sep 2020

A study contradicting the phenotypical relationship between plasmablasts and developing neutrophils

A team of scientists from Australia challenges the findings of a recent study by Wilk et al. demonstrating that plasmablasts transdifferentiate into developing neutrophils in severe coronavirus disease 2019 (COVID-19). The Australian study is currently available on the bioRxiv preprint server.

29 Sep 2020

SARS-CoV-2 infects human embryonic epithelial and lung cells

As COVID-19 continues to spread the world over, investigators are still trying to understand how it ravages the human body. A recent study published on the preprint server bioRxiv in September 2020 shows that the virus is capable of infecting human embryonic cells that are destined to form the epithelial surfaces of the body, both internal and external, as well as lung cells.

29 Sep 2020

Discovery of specific kinase as a novel drug target against SARS-CoV-2 and other coronaviruses

By using a modern genome-wide knockout approach to single out coronavirus host factors in human cells, researchers from Rega Institute in Belgium discovered a potential new target that might be exploited for developing drugs against the ongoing coronavirus disease (COVID-19) pandemic, but also future outbreaks of highly pathogenic coronaviruses

29 Sep 2020

Researchers use fruit fly to develop a novel disease model for Pitt-Hopkins syndrome

The researchers from the TalTech molecular neurobiology laboratory headed by professor Tõnis Timmusk used the fruit fly, Drosophila melanogaster to develop a novel disease model for Pitt-Hopkins syndrome (PTHS).

29 Sep 2020

Computer model unravels mystery behind severe inflammation in people with COVID-19

A study from the University of Pittsburgh School of Medicine and Cedars-Sinai addresses a mystery first raised in March: Why do some people with COVID-19 develop severe inflammation?

29 Sep 2020

A special issue on the emerging COVID-19 infection

Acta Pharmaceutica Sinica B publishes special issue on 'Research on Emerging COVID-19 (Target, Mechanism, and Therapeutics)' edited by Hai-Bin Luo, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China; Shilin Chen, Institute of Chinese Materia Medica, Beijing, China and Peiqing Liu, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China.

29 Sep 2020

Fasting blood glucose levels upon admission tied to COVID-19 prognosis, study finds

In the study, which appeared on the pre-print open-source medRxiv* server, the investigators aimed to determine the prognostic value of blood glucose in predicting outcomes in COVID-19 disease, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

28 Sep 2020

Smell and taste changes last longer than other COVID-19 symptoms

A preprint paper published on the medRxiv server details a recent study by researchers from The Hebrew University, Hadassah-Hebrew University medical center, and Hadassah University Hospital, which addresses this gap in knowledge about the symptoms experienced by COVID-19 patients.

28 Sep 2020

SARS-CoV-2 re-infection is real but rare: Case study

Now, American researchers have looked at all reported cases of re-infection and the possible reasons behind them. Their study titled, “Re-infection with SARS-CoV-2 and Failure of Humoral Immunity: a case report,” is published online on the preprint server medRxiv in September 2020.

28 Sep 2020

Cincinnati Children's research leads to approval of new drug for hypereosinophilic syndrome

Following two decades of research on a group of rare diseases called hypereosinophilic syndrome at Cincinnati Children's Hospital Medical Center, the U.S. Food and Drug Administration has approved the drug Nucala (mepolizumab) for use in the treatment of patients with hypereosinophilic syndrome.

28 Sep 2020

Syndrome News and Research

SARS-CoV-2 D614G variant enhances infectivity, replication and transmission

Danish vs. Swedish data shows social interaction major risk factor for SARS-CoV-2 infection

A TLR2 agonist reduces SARS-CoV-2 in upper respiratory tract of ferret model

Different triggers for Kawasaki disease suggest slightly different genetic susceptibilities

Researchers develop research model to understand the impact of coronavirus on lungs

Sleep apnea increases risk of severe COVID 19

College football crowds could impact COVID-19 spread

New graphical tool to identify potent neutralizing antibodies against SARS-CoV-2

Australian scientists develop a nasal spray that could stop SARS-CoV-2 infection

Case fatality rates for COVID-19 and health indicators

A study contradicting the phenotypical relationship between plasmablasts and developing neutrophils

SARS-CoV-2 infects human embryonic epithelial and lung cells

Discovery of specific kinase as a novel drug target against SARS-CoV-2 and other coronaviruses

Researchers use fruit fly to develop a novel disease model for Pitt-Hopkins syndrome

Computer model unravels mystery behind severe inflammation in people with COVID-19

A special issue on the emerging COVID-19 infection

Fasting blood glucose levels upon admission tied to COVID-19 prognosis, study finds

Smell and taste changes last longer than other COVID-19 symptoms

SARS-CoV-2 re-infection is real but rare: Case study

Cincinnati Children's research leads to approval of new drug for hypereosinophilic syndrome

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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