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Vaccine generates antibodies that target SARS-CoV-2 spike protein regions shared among many coronaviruses

Could the SARS-CoV-2 vaccine reawaken previous antibody responses and point the way to a universal coronavirus vaccine? A new analysis of the antibody response to a COVID-19 vaccine suggests the immune system's history with other coronaviruses, including those behind the common cold, shapes the patient's response, according to a study published today in Cell Reports.

6 Jul 2022

COVID-19 vaccination with bacterial peptide conjugated to receptor-binding domain elicits potent immune response

In a new study, researchers assessed the efficiency of immunization with a bacterial peptide conjugated to the SARS-CoV-2 receptor-binding domain against SARS-CoV-2 infection.

6 Jul 2022

Targeting C5a/C5aR1 signaling ameliorates COVID-19 immunopathology

A new study investigated the role of complement component 5a (C5a) and its receptor (C5a receptor type 1, C5aR1) in the pathophysiology of COVID-19.

6 Jul 2022

Damon Runyon Cancer Research Foundation names five new Damon Runyon Clinical Investigators

The Damon Runyon Cancer Research Foundation has named five new Damon Runyon Clinical Investigators.

6 Jul 2022

Researchers challenge centuries-old beliefs about limb regeneration

Ken Muneoka is no stranger to disrupting the field of regeneration; for example, in a 2019 ground-breaking publication in Nature, the Texas A&M University College of Veterinary Medicine & Biomedical Sciences professor proved for the first time that joint regeneration in mammals was possible.

6 Jul 2022

Study reports how opioids cause gastric inflammation

Opioids are the gold standard for treatment of chronic and acute pain; however, their use may result in significant gastrointestinal side effects, including nausea, vomiting, and constipation.

6 Jul 2022

Novel method poses broad potential for the study of microbiota on a new, functional level

A research group from Turku Bioscience Centre, Finland, has developed a new method for studying the functionality of microbiota through metaproteomics.

6 Jul 2022

Running faster and dreaming help your left brain and right brain to communicate better

You’re out jogging and suddenly notice a low-hanging tree branch in your path. You quickly lower your head, narrowly avoiding the branch, and continue on the run without giving it another thought.

6 Jul 2022

Study yields molecular clues that could lead to new treatments for rare genetic disease

A new stem cell study by KAUST researchers helps to explain a rare genetic disease called Wiskott-Aldrich syndrome (WAS), yielding molecular clues that could lead to new treatments for a devastating immune deficiency disorder.

6 Jul 2022

Genetically engineered kidney organoids solve mystery of a rare disease

Researchers have solved a medical mystery in a poorly understood disease by uncovering which cells cause tumors in patients with tuberous sclerosis complex (TSC).

6 Jul 2022

The host cell membrane binding surfaces of SARS-CoV-2 spike variants

Researchers identified SARS-CoV-2 spike surfaces involved in binding to host cell membranes.

6 Jul 2022

Beyond COVID-19: the potential future applications of mRNA vaccines

Researchers described the production, mechanisms, and potential applications of mRNA vaccines.

6 Jul 2022

Study finds flaviviruses can manipulate host skin microbiota to produce a scent that attracts mosquitoes

Researchers assessed the impact of mosquito-transmitted flaviviruses on host skin microbiota.

6 Jul 2022

Intrahost genetic diversity and evolution of the SARS-CoV-2 B.1.517 lineage during chronic infection of an immunocompromised individual

Researchers investigated the intrahost evolution and genetic diversity of the SARS-CoV-2 B.1.517 variant in an immunosuppressed person with chronic COVID-19.

6 Jul 2022

New model reveals cancer-driving mutations

In this interview, News-Medical speaks to Maxwell Sherman, an MIT graduate student and one of the lead authors of a study that used a new method to investigate cancer genomes.

6 Jul 2022

How does hybrid immunity shape humoral immune response to SARS-CoV-2?

In a recent study posted to the medRxiv* preprint server, researchers illustrated that hybrid severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunity widens effective humoral signatures of SARS-CoV-2 vaccinations.

6 Jul 2022

New atomic-level models of spike protein play a key role in COVID-19 infection and immunity

When the coronavirus causing COVID-19 infects human cells, the cell's protein-processing machinery makes modifications to the spike protein that render it more flexible and mobile, which could increase its ability to infect other cells and to evade antibodies, a new study from the University of Illinois Urbana-Champaign found.

6 Jul 2022

Bone marrow transplants may be an effective treatment for ALS, research suggests

Along with the central nervous system, the immune system may play a fundamental role in Amyotrophic Lateral Sclerosis (ALS), suggesting that bone marrow transplants may be an effective novel treatment for the neurodegenerative disease.

6 Jul 2022

Paxlovid resistance associated with SARS-CoV-2 3CLpro mutations

In a recent study published in the bioRxiv* preprint server, researchers at the Medical University of Innsbruck assessed the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 3CLpro mutations responsible for Paxlovid resistance. The 3-chymotrypsin-like protease (3CLPro), or main protease (Mpro), is the main protease found in coronaviruses.

6 Jul 2022

Healthy, cancer, and immunosuppressed patients all benefit from COVID boosters

In a recent study posted to the medRxiv* pre-print server, researchers developed a mechanistic mathematical model to predict the course of vaccine-induced immunity in healthy and immunosuppressed patients for the long term, exceeding the time frames for which clinical data is currently available.

5 Jul 2022

B Cell News and Research

Vaccine generates antibodies that target SARS-CoV-2 spike protein regions shared among many coronaviruses

COVID-19 vaccination with bacterial peptide conjugated to receptor-binding domain elicits potent immune response

Targeting C5a/C5aR1 signaling ameliorates COVID-19 immunopathology

Damon Runyon Cancer Research Foundation names five new Damon Runyon Clinical Investigators

Researchers challenge centuries-old beliefs about limb regeneration

Study reports how opioids cause gastric inflammation

Novel method poses broad potential for the study of microbiota on a new, functional level

Running faster and dreaming help your left brain and right brain to communicate better

Study yields molecular clues that could lead to new treatments for rare genetic disease

Genetically engineered kidney organoids solve mystery of a rare disease

The host cell membrane binding surfaces of SARS-CoV-2 spike variants

Beyond COVID-19: the potential future applications of mRNA vaccines

Study finds flaviviruses can manipulate host skin microbiota to produce a scent that attracts mosquitoes

Intrahost genetic diversity and evolution of the SARS-CoV-2 B.1.517 lineage during chronic infection of an immunocompromised individual

New model reveals cancer-driving mutations

How does hybrid immunity shape humoral immune response to SARS-CoV-2?

New atomic-level models of spike protein play a key role in COVID-19 infection and immunity

Bone marrow transplants may be an effective treatment for ALS, research suggests

Paxlovid resistance associated with SARS-CoV-2 3CLpro mutations

Healthy, cancer, and immunosuppressed patients all benefit from COVID boosters

Using single B cell screening to boost antibody discovery eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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