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Omicron spike N679K mutation acts as a loss-of-function mutation attenuating SARS-CoV-2 in vitro & in vivo

Researchers explored the impact of a loss-of-function mutation in the SARS-CoV-2 Omicron variants on the expression of the spike protein.

20 Apr 2023

Protective mucosal and systemic immunity provided by a single-dose novel live-attenuated intranasal SARS-CoV-2 vaccine candidate

Researchers explored the protective systemic and mucosal immunity provided by a single dose of a live-attenuated SARS-CoV-2 vaccine candidate.

20 Apr 2023

Study indicates that SARS-CoV-2 has evolved to gain increased replicative fitness and become well-adapted in epithelial cells of human airways

Researchers explored increasing replicative fitness of emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants

20 Apr 2023

Protein OCLN found to play crucial role in SARS-CoV-2 cell-to-cell transmission

Research explains how the SARS-CoV-2 virus spreads efficiently by directly infecting neighboring cells through a process called cell-to-cell transmission. The virus uses a protein called occludin (OCLN) to enter the cells and causes syncytium formation, which leads to viral spread.

20 Apr 2023

Sex-specific differences in the risk and resilience for Alzheimer's disease

Two-thirds of people living with Alzheimer's disease in the United States are women, according to the Alzheimer's Association's 2019 Alzheimer's Disease Facts & Figures report.

19 Apr 2023

First-in-human clinical study begins investigating the duoCAR T-cell therapy for treatment of HIV

UC Davis Health researchers have dosed the second participant in their clinical trial looking to identify a potential cure for HIV utilizing CAR T-cell therapy.

19 Apr 2023

Mice study reveals a way to turn back the clock after heart attack

A recent study using mice has revealed a way to turn back the clock after heart attack. The researchers behind the work used RNAs to instruct cells in an injured heart to eliminate scar tissue and recreate cardiac muscle, allowing the heart to function like new again.

19 Apr 2023

Infectious particles of the SARS-CoV-2 virus isolated from hospital air

Quebec scientists have succeeded in isolating infectious particles of the SARS-CoV-2 virus from air samples collected from hospital rooms of COVID-19 patients and kept frozen for more than a year, a new study shows.

19 Apr 2023

Researchers develop novel molecular nanocages for siRNA delivery

Small interfering RNAs (siRNAs) are novel therapeutics that can be used to treat a wide range of diseases.

19 Apr 2023

Clinical trial may set a new 'gold standard' for the treatment of childhood craniopharyngioma

St. Jude Children's Research Hospital is reporting phase 2 clinical trial results treating the brain tumor craniopharyngioma with proton therapy.

19 Apr 2023

Researchers compare the action of natural and therapeutic opioids

The human body naturally produces opioid-like substances, such as endorphins, which block the perception of pain and increase the feeling of well-being.

19 Apr 2023

Next-generation vaccine strategies to combat current and emerging SARS-CoV-2 variants

Announcing a new article publication for Zoonoses journal. Vaccines are among the most effective medical countermeasures against infectious diseases.

19 Apr 2023

Study reveals a previously unknown mechanism for DNA folding

A hitherto unknown mechanism for DNA folding is described in a study in Nature published by researchers from Karolinska Institutet and the Max Planck Institute for Biophysics.

19 Apr 2023

Study advances understanding of how melanocyte stem cells work to color hair

Certain stem cells have a unique ability to move between growth compartments in hair follicles, but get stuck as people age and so lose their ability to mature and maintain hair color, a new study shows.

19 Apr 2023

Novel imaging method shows link between iron redox and Alzheimer’s disease

There is a growing body of evidence that iron in the brain may play a role in Alzheimer's disease. Lending weight to that idea, a new imaging probe has for the first time shown that in the same regions of the brain where the amyloid beta plaques associated with Alzheimer's occur, there is also an increase in iron redox, meaning the iron in these regions is more reactive in the presence of oxygen.

19 Apr 2023

Newly discovered protein may be pivotal for traumatic heterotopic ossification

A team led by UT Southwestern Medical Center researchers has discovered a protein that appears to be pivotal for traumatic heterotopic ossification (HO), a condition in which bone forms in muscles, tendons, and other soft tissues after traumatic injury or surgery.

19 Apr 2023

Small vesicles released by intestinal bacteria induce immune activation and progression of liver cirrhosis

Researchers from Niigata University and Kyoto Prefectural University have revealed that small vesicles, around 100 nm in size, released by intestinal bacteria induce immune activation and progression of liver cirrhosis, as well as reduction of serum albumin level, subsequently leading to edema and ascites.

19 Apr 2023

Cell News and Research

Omicron spike N679K mutation acts as a loss-of-function mutation attenuating SARS-CoV-2 in vitro & in vivo

Protective mucosal and systemic immunity provided by a single-dose novel live-attenuated intranasal SARS-CoV-2 vaccine candidate

Study indicates that SARS-CoV-2 has evolved to gain increased replicative fitness and become well-adapted in epithelial cells of human airways

Protein OCLN found to play crucial role in SARS-CoV-2 cell-to-cell transmission

Sex-specific differences in the risk and resilience for Alzheimer's disease

First-in-human clinical study begins investigating the duoCAR T-cell therapy for treatment of HIV

Mice study reveals a way to turn back the clock after heart attack

Infectious particles of the SARS-CoV-2 virus isolated from hospital air

Researchers develop novel molecular nanocages for siRNA delivery

Clinical trial may set a new 'gold standard' for the treatment of childhood craniopharyngioma

Researchers compare the action of natural and therapeutic opioids

Next-generation vaccine strategies to combat current and emerging SARS-CoV-2 variants

Study reveals a previously unknown mechanism for DNA folding

Study advances understanding of how melanocyte stem cells work to color hair

Novel imaging method shows link between iron redox and Alzheimer’s disease

Newly discovered protein may be pivotal for traumatic heterotopic ossification

Small vesicles released by intestinal bacteria induce immune activation and progression of liver cirrhosis

Is there an association between exposure to ultrafine particles during pregnancy and influenza infection severity?

Could laughter yoga be a therapeutic approach for type 2 diabetic glycemic control?

Discovery offers a potential target for TB therapies

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