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Study provides important insights into prostate cancer metabolism

South Australian medical researchers have identified a new way in which prostate cancer cells use glucose to grow and survive, which in turn could be the secret to destroying them.

27 Aug 2021

New machine learning techniques help resolve structural biology challenges

Determining the 3D shapes of biological molecules is one of the hardest problems in modern biology and medical discovery. Companies and research institutions often spend millions of dollars to determine a molecular structure – and even such massive efforts are frequently unsuccessful.

27 Aug 2021

New machine learning method enhances computational prediction of RNA structures

Researchers present ARES (Atomic Rotationally Equivariant Scorer) – a machine learning method that significantly improves the computational prediction of RNA structures over previous approaches. Like proteins, RNA molecules twist and fold into intricate three-dimensional shapes that are crucial to their function.

27 Aug 2021

Testing for inflammatory proteins will help diagnose earlier onset, progression of Alzheimer’s disease

Testing for some inflammatory proteins associated with the nervous and immune systems will help diagnose the earlier onset and progression of Alzheimer's disease, according to a Rutgers study.

26 Aug 2021

FDA releases the results of first PFAS survey in nationally distributed processed foods

Today, the U.S. Food and Drug Administration released the results of the first survey of per- and polyfluoroalkyl substances (PFAS) in nationally distributed processed foods, including several processed baby foods, collected from the agency's Total Diet Study (TDS), which monitors levels of nutrients and contaminants in foods consumed in the U.S.

26 Aug 2021

Neuroinflammation is the key upstream mechanism in Alzheimer’s disease progression

Neuroinflammation is the key driver of the spread of pathologically misfolded proteins in the brain and causes cognitive impairment in patients with Alzheimer's disease, researchers from the University of Pittsburgh School of Medicine reveal in a paper published today in Nature Medicine.

26 Aug 2021

Technique sheds new light on the processes involved in kidney stone formation

Up to 15% of people will experience kidney stones, and for 50% of those that do, they will recur. It is therefore important to understand as much as possible about how kidney stones form to improve both prevention and treatment.

26 Aug 2021

Researchers reveal mechanism underlying most common cause of epileptic seizures

During fetal development, cells should migrate to the outer edge of the brain to form critical connections for information transfer and regulation in the body.

26 Aug 2021

Restoring DAXX protein levels may prevent misfolding of rogue proteins known to drive Alzheimer's

For the first time, Penn Medicine researchers showed how restoring levels of the protein DAXX and a large group of similar proteins prevents the misfolding of the rogue proteins known to drive Alzheimer's and other neurodegenerative diseases, as well as certain mutations that contribute to cancers.

26 Aug 2021

Pregnant women with COVID-19 are more susceptible to pre-eclampsia

A review of the scientific literature published by Brazilian researchers shows that pregnant women infected by the novel coronavirus run a higher risk of developing pre-eclampsia, a pregnancy complication characterized by persistent high blood pressure, usually in the second half of pregnancy or shortly after delivery.

26 Aug 2021

Oral mucosa identified as potential target for SARS-CoV-2 infection

A recent study suggested that ACE2 receptors are expressed in oral tissues, making the oral cavity an important potential entry point of SARS-CoV-2.

26 Aug 2021

The influence of COVID-19 on platelet activation and aggregation

In a paper recently uploaded to the bioRxiv* preprint server, humanized ACE2 mice are infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and platelets are subsequently isolated from the blood for quantitative proteomic analysis.

26 Aug 2021

Scientists assess SARS-CoV-2 mutants in ferret hosts

In a paper recently uploaded to the preprint server bioRxiv* by the cause of SARS-CoV-2 mutations observed in mink and ferrets is investigated, and the danger posed by such mutations to humans assessed.

26 Aug 2021

Brain organoids provide a valuable model to study autism

Variations in the 16p11.2 region of the genome are associated with autism spectrum disorder. While people with genetic deletions in this region have larger heads (macrocephaly) and people with genetic duplications have smaller heads (microcephaly), both variation types affect brain development and function.

26 Aug 2021

Two mRNA vaccines are effective even without post-shot symptoms or prior SARS-CoV-2 infection

Vaccination with the two messenger RNA (mRNA) vaccines for SARS-CoV-2, the virus that causes COVID-19, yields a robust antibody response, even if a person did not develop significant symptoms following vaccination or did not have a prior SARS-CoV-2 infection.

26 Aug 2021

Researchers identify potential new treatment for osteoarthritis

Osteoarthritis (OA) is a debilitating joint disease that affects millions of individuals worldwide. Common in the older adult population, OA is associated with loss of cartilage over time.

26 Aug 2021

Research offers new insight into how to treat endometriosis

Endometriosis is a painful, chronic condition in which tissue from the uterus inappropriately grows outside the uterus.

26 Aug 2021

Study unravels widespread tumor suppression mechanism that halts cancer metastasis

According to a study by The Wistar Institute, the tumor suppressor Parkin, whose levels are reduced in different cancer types, causes acute metabolic and oxidative stress, suppresses mitochondrial trafficking, and blocks tumor cell movement, reducing primary and metastatic tumor growth.

26 Aug 2021

Could soluble CD24 offer some hope against severe COVID-19?

A recent randomized phase III trial conducted by researchers at the Ohio State University, Columbus, OH, US, evaluated the impact of CD24Fc in severe COVID-19 patients and showed promising clinical efficacy. This study is available as a preprint on the medRxiv* server.

26 Aug 2021

MSK researchers identify potential biomarker of response to checkpoint immunotherapy

In recent years, immune-based treatments for cancer have buoyed the hopes of doctors and patients alike. Drugs called immune checkpoint inhibitors have provided lifesaving benefits to a growing list of people with several types of cancer, including melanoma, lung cancer, bladder cancer, and many more.

25 Aug 2021