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Clearer understanding of ORC offers new insight into fundamental DNA replication initiation mechanisms

A clearer understanding of the origin recognition complex (ORC) - a protein complex that directs DNA replication - through its crystal structure offers new insight into fundamental mechanisms of DNA replication initiation. This will also provide insight into how ORC may be compromised in a subset of patients with Meier-Gorlin syndrome, a form of dwarfism in humans.

9 Apr 2015

Northwestern Medicine launches mobile 'therapist' to combat depression, anxiety

Feeling blue or anxious? Now, there's a mobile 'therapist' designed to understand you and suggest the ideal mini-app to lift your particular mood.

9 Apr 2015

Study looks at connections between cerebral cortex and cerebellum in children with autism

In early childhood, the neurons inside children's developing brains form connections between various regions of brain "real estate." As described in a paper published last week in the journal Biological Psychiatry, cognitive neuroscientists at San Diego State University found that in children and adolescents with autism spectrum disorder, the connections between the cerebral cortex and the cerebellum appear to be overdeveloped in sensorimotor regions of the brain.

9 Apr 2015

Biologists discover vulnerability of brain cancer cells

Biologists at MIT and the Whitehead Institute for Biomedical Research have discovered a vulnerability of brain cancer cells that could be exploited to develop more-effective drugs against brain tumors.

9 Apr 2015

Phase 2 IMAGO trial of SHP625 fails to meet primary endpoints in pediatric patients with ALGS

Shire plc today announced that the 13-week Phase 2 IMAGO trial of its investigational compound SHP625 (LUM001) did not meet the primary or secondary endpoints in the study of 20 pediatric patients with Alagille syndrome (ALGS), a rare, life-threatening genetic disorder that presents with chronic cholestasis (accumulation of bile acids in the liver) and severe pruritus (itching).

9 Apr 2015

Indoor UV tanning causes skin cancer

The U.S. Surgeon General should declare that indoor ultraviolet radiation tanning causes skin cancer, according to an article published today by the American Journal of Preventive Medicine.

9 Apr 2015

Yale University-led research explores directional cues that influence cancer cells

Scientists are mapping the habits of cancer cells, turn by microscopic turn. Using advanced technology and an approach that merges engineering and medicine, a Yale University-led team has compiled some of the most sophisticated data yet on the elaborate signaling networks directing highly invasive cancer cells. Think of it as a digital field guide for a deadly scourge.

9 Apr 2015

Researchers find Fountain of Youth while conducting breast cancer research

The Fountain of Youth has been discovered and it's not in Florida as Ponce de Leon claimed. Instead, it was found in the mammary glands of genetically modified mice.

9 Apr 2015

Plymouth researchers receive grant to develop effective therapy for Huntington's disease

Huntington's disease is an hereditary disorder of the nervous system caused by a faulty gene on chromosome four. The faulty gene leads to nerve damage in the area of the brain resulting in gradual physical, mental and emotional changes. Those born to a parent with Huntington's disease have a 50:50 chance of developing it, and there is currently no cure.

9 Apr 2015

Diet rich in high glucoraphanin broccoli reduces blood LDL-cholesterol levels by around 6%

Including a new broccoli variety in the diet reduces blood LDL-cholesterol levels by around 6%, according to the results of human trials led by the Institute of Food Research.

9 Apr 2015

TABS study: Older people can improve their health by reducing sitting time

"I feel lethargic when I sit all day," said Gerald Alexander, an 82-year-old retired social service worker among the 25 Group Health patients who participated in the Take Active Breaks from Sitting (TABS) pilot study. "I feel much peppier when I stand and take walks."

9 Apr 2015

Understanding emotional processing deficit

Kessler Foundation researchers have linked the inability to recognize facial affect (emotion) with white matter damage after traumatic brain injury (TBI), an important first step toward understanding this emotional processing deficit. Their findings indicate a pattern of white matter damage and gray matter atrophy associated with this specific impairment of social cognition after TBI.

9 Apr 2015

UL researchers awarded €250,000 to develop assistive exoskeletons for older adults

Researchers at the Design Factors Research Group at the University of Limerick have been awarded €250,000 funding to develop an exoskeleton to assist older adults. The research will be carried out as part of the AXO-SUIT project, which will run for 3 years with a total budget of almost €3 million. UL will partner with Cork based company MTD Ltd in the design and manufacture of the concept.

9 Apr 2015

Countdown begins for 10th BIOVISION forum

The countdown begins with only one week to go until the life science event of the year. The BIOVISION forum is now in it’s 10th year, hosting over 1,500 attendees from the international health care and life sciences sector.

9 Apr 2015

Short-term balance program can reduce risk of falling in older population

Falling is bad news for senior citizens—oftentimes resulting in life-changing injuries, such as hip fractures and head traumas, and an increased risk of early death. New research findings at University of the Sciences into how and why seniors fall may provide healthcare providers with insight on improved balance and strength-training strategies to prevent tumbles by the elderly.

8 Apr 2015

$Incidence, costs of osteoporotic fractures in China to double by 2035$

Incidence, costs of osteoporotic fractures in China to double by 2035

The results of the first study using a health economics model to project osteoporosis-related fractures and costs for the Chinese population, shows that the country's healthcare system will face a dramatic rise in costs over the next few decades.

8 Apr 2015

UTMB scientists develop quick-acting vaccine that is effective against Ebola strain

An interdisciplinary team from The University of Texas Medical Branch at Galveston and Profectus BioSciences, Inc. has developed a quick-acting vaccine that is both safe and effective with a single dose against the Ebola strain that killed thousands of people in West Africa last year.

8 Apr 2015

Phase 1 clinical trial: Anti-HIV antibody significantly decreases HIV levels

A single infusion of an experimental anti-HIV antibody called 3BNC117 resulted in significantly decreased HIV levels that persisted for as long as 28 days in HIV-infected individuals, according to Phase 1 clinical trial findings published online today in Nature.

8 Apr 2015

Changes in height can affect risk of coronary heart disease

The shorter you are- the more your risk of coronary heart disease. That's the key finding of a new study led by the University of Leicester which discovered that every 2.5 inches change in your height affected your risk of coronary heart disease by 13.5%. For example, compared to a 5ft 6inch tall person, a 5 foot tall person on average has a 32% higher risk of coronary heart disease because of their relatively shorter stature.

8 Apr 2015

Prolong Pharmaceuticals' SANGUINATE granted FDA Orphan Drug Designation for SCD treatment

Prolong Pharmaceuticals, LLC, a biopharmaceutical company dedicated to developing products for the treatment of anemias, cancers and their debilitating comorbidities, announced today that the U.S. Food and Drug Administration has granted Orphan Drug Designation for its flagship product SANGUINATE for the treatment of Sickle Cell Disease (SCD).

8 Apr 2015

Research News and Research

Clearer understanding of ORC offers new insight into fundamental DNA replication initiation mechanisms

Northwestern Medicine launches mobile 'therapist' to combat depression, anxiety

Study looks at connections between cerebral cortex and cerebellum in children with autism

Biologists discover vulnerability of brain cancer cells

Phase 2 IMAGO trial of SHP625 fails to meet primary endpoints in pediatric patients with ALGS

Indoor UV tanning causes skin cancer

Yale University-led research explores directional cues that influence cancer cells

Researchers find Fountain of Youth while conducting breast cancer research

Plymouth researchers receive grant to develop effective therapy for Huntington's disease

Diet rich in high glucoraphanin broccoli reduces blood LDL-cholesterol levels by around 6%

TABS study: Older people can improve their health by reducing sitting time

Understanding emotional processing deficit

UL researchers awarded €250,000 to develop assistive exoskeletons for older adults

Countdown begins for 10th BIOVISION forum

Short-term balance program can reduce risk of falling in older population

Incidence, costs of osteoporotic fractures in China to double by 2035

UTMB scientists develop quick-acting vaccine that is effective against Ebola strain

Phase 1 clinical trial: Anti-HIV antibody significantly decreases HIV levels

Changes in height can affect risk of coronary heart disease

Prolong Pharmaceuticals' SANGUINATE granted FDA Orphan Drug Designation for SCD treatment

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