Gastroenterology News and Research

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Gastroenterology is the branch of medicine where the digestive system and its disorders are studied.

Researchers develop tool that speeds up analysis and publication of biomedical data

Researchers at the Icahn School of Medicine at Mount Sinai have developed a tool that speeds up the analysis and publication of biomedical data from many months or years to mere minutes, transforming the way researchers communicate results of their studies.

15 Nov 2018

Fecal microbiota transplantation effective against ICI-associated colitis

For the first time, transplanting gut bacteria from healthy donors was used to successfully treat patients suffering from severe colitis caused by treatment with immune checkpoint inhibitors.

12 Nov 2018

Scientist wins award for research in the field of commensal microbiota

The winner of the Johanna Duermueller-Bol DBMR Research Award 2018 is Dr. Stephanie Ganal-Vonarburg. As a Senior Scientist, she conducts research in the Gastroenterology / Mucosal Immunology Research Laboratory at Bern University Hospital and at the Department for BioMedical Research at the University of Bern.

8 Nov 2018

Regenstrief scientist calls for precision surveillance for colon cancer screening

The interval at which an individual undergoes a repeat colonoscopy because of previous pre-cancerous polyps -- a practice known as "surveillance" -- should be tailored to the individual and not simply be determined by the results of prior colonoscopies, according to Regenstrief Institute research scientist Thomas F. Imperiale, M.D.

8 Nov 2018

AI in medical space must be carefully tested for performance across wide range of populations

Artificial intelligence tools trained to detect pneumonia on chest X-rays suffered significant decreases in performance when tested on data from outside health systems, according to a study conducted at the Icahn School of Medicine at Mount and published in a special issue of PLOS Medicine on machine learning and health care.

6 Nov 2018

Researchers find key differences in brains of males and females with schizophrenia

Researchers from the Icahn School of Medicine at Mount Sinai have found clear disparities in the way males and females--both those with schizophrenia and those who are healthy--discern the mental states of others.

30 Oct 2018

The Lancet Infectious Diseases journal publishes clinical trial results for Shionogi’s cefiderocol

Shionogi & Co., Ltd. announced today that The Lancet Infectious Diseases journal has published clinical results from the pivotal randomized controlled trial evaluating cefiderocol for the treatment of complicated urinary tract infection in patients at risk of multidrug-resistant Gram-negative infections.

26 Oct 2018

New approach using 'cellular dust' offers hope for regenerative medicine

While stem cells have the most therapeutic potential, the benefits of regenerative medicine may best be mobilized using extracellular vesicles (EVs), also known in the past as "cellular dust".

24 Oct 2018

Biological factors not responsible for racial differences in colorectal cancer incidence

A systematic review and meta-analysis from the Regenstrief Institute and Indiana University School of Medicine has found that, in spite of the higher incidence and death rate of colorectal cancer in blacks, no difference exists in the overall prevalence of advanced, precancerous polyps between average-risk blacks and whites who underwent a screening colonoscopy.

24 Oct 2018

AbbVie’s U-ACHIEVE Phase 2b/3 dose-ranging study improves outcomes in patients with ulcerative colitis

AbbVie, a research-based global biopharmaceutical company, today announced positive results from U-ACHIEVE, an ongoing Phase 2b/3 dose-ranging study evaluating upadacitinib, an investigational JAK1-selective inhibitor, for induction and maintenance therapy in adult patients with moderately to severely active ulcerative colitis.

23 Oct 2018

Plastics now commonly found in human stools

Nearly eight billion metric tons of plastic finds its way into the oceans each year. This huge amount of plastic either washes ashore or breaks down into tiny pieces that are less than 5 millimeters in diameter and are called microplastics.

22 Oct 2018

Study: Targeting specific genomic mutation in breast cancer improves survival

Targeting a common mutation in patients with hormone receptor positive (HR+) HER2 negative (HER2-) advanced breast cancer with the alpha-specific phosphatidylinositol-3-kinase (PI3K) inhibitor alpelisib significantly improves progression-free survival, according to late-breaking results reported at ESMO 2018.

22 Oct 2018

Takeda presents vedolizumab phase 3 VISIBLE 1 trial results for treatment of moderately to severely active ulcerative colitis

Takeda Pharmaceutical Company Limited today announced results from the phase 3 VISIBLE 1 clinical trial evaluating the efficacy and safety of an investigational subcutaneous formulation of the gut-selective biologic vedolizumab for maintenance therapy in adult patients with moderately to severely active ulcerative colitis who achieved clinical response* at week 6 following two doses of open-label vedolizumab intravenous induction therapy.

22 Oct 2018

At-home biofeedback therapy effective in relieving difficult-to-treat constipation

Biofeedback therapy used at home is about 70 percent effective at helping patients learn how to coordinate and relax bowel muscles and relieve one of the most difficult-to-treat types of constipation, investigators report.

22 Oct 2018

Takeda announces positive Phase 3 ALTA-1L data in first-line therapy for advanced ALK+ NSCLC

Takeda Pharmaceutical Company Limited today announced that intracranial efficacy data from the Phase 3 ALTA-1L (ALK in Lung Cancer Trial of BrigAtinib in 1st Line) trial showed improved intracranial progression-free survival (PFS) and intracranial objective response rate (ORR) with ALUNBRIG (brigatinib) compared to crizotinib among anaplastic lymphoma kinase-positive (ALK+) non-small cell lung cancer (NSCLC) patients.

22 Oct 2018

Shorter course of trastuzumab could be an option for women with HER2+ early breast cancer

Women with HER2-positive early breast cancer with small tumours have similar disease-free survival and lower risk of cardiac toxicity with a nine-week course of adjuvant trastuzumab compared to those treated for one year, according to a subgroup analysis of the Short-HER trial reported at ESMO 2018 Congress in Munich.

22 Oct 2018

Study reports increased risk of death in children with inflammatory bowel disease

Children who develop inflammatory bowel disease (ulcerative colitis or Crohn's disease) have an increased risk of death, both in childhood and later in life, a study from Karolinska Institutet in Sweden published in the journal Gastroenterology reports.

19 Oct 2018

One-time universal screening recommended to tackle increase in hepatitis C

Physicians are encountering a growing number of younger patients who are testing positive for hepatitis C virus fueled largely by the opioid crisis impacting communities around the country.

17 Oct 2018

Researchers design modeling system to infer relationships between genes, drugs, and their environment

A team of researchers at the Icahn School of Medicine at Mount Sinai and the University of Washington has designed a modeling system that integrates genomic and temporal information to infer causal relationships between genes, drugs, and their environment, allowing for a more accurate prediction of their interactions over time.

11 Oct 2018

Bug that causes stomach cancer may increase risk of colorectal cancers

A bacterium known for causing stomach cancer might also increase the risk of certain colorectal cancers, particularly among African Americans, according to a study led by Duke Cancer Institute researchers.

10 Oct 2018

Gastroenterology News and Research

Further Reading

Researchers develop tool that speeds up analysis and publication of biomedical data

Fecal microbiota transplantation effective against ICI-associated colitis

Scientist wins award for research in the field of commensal microbiota

Regenstrief scientist calls for precision surveillance for colon cancer screening

AI in medical space must be carefully tested for performance across wide range of populations

Researchers find key differences in brains of males and females with schizophrenia

The Lancet Infectious Diseases journal publishes clinical trial results for Shionogi’s cefiderocol

New approach using 'cellular dust' offers hope for regenerative medicine

Biological factors not responsible for racial differences in colorectal cancer incidence

AbbVie’s U-ACHIEVE Phase 2b/3 dose-ranging study improves outcomes in patients with ulcerative colitis

Plastics now commonly found in human stools

Study: Targeting specific genomic mutation in breast cancer improves survival

Takeda presents vedolizumab phase 3 VISIBLE 1 trial results for treatment of moderately to severely active ulcerative colitis

At-home biofeedback therapy effective in relieving difficult-to-treat constipation

Takeda announces positive Phase 3 ALTA-1L data in first-line therapy for advanced ALK+ NSCLC

Shorter course of trastuzumab could be an option for women with HER2+ early breast cancer

Study reports increased risk of death in children with inflammatory bowel disease

One-time universal screening recommended to tackle increase in hepatitis C

Researchers design modeling system to infer relationships between genes, drugs, and their environment

Bug that causes stomach cancer may increase risk of colorectal cancers

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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