Genetic Engineering News and Research

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Injection of genetically modified virus effectively treats metastatic melanoma patients

Injection of a genetically modified virus that induces the body's own immune cells to attack metastatic melanoma effectively treated almost 40 percent of patients with tumors that could not be surgically removed, according to researchers from three prominent cancer centers in a study published as an "article in press" on the Journal of the American College of Surgeons website in advance of print publication.

28 Jan 2019

Defective molecular master switch could lead to age-related macular degeneration

A signaling pathway controlled by transforming growth factor beta (TGF-beta) could be involved in the progression of age-related macular degeneration.

22 Jan 2019

Sartorius launches BIOSTAT RM TX single-use bioreactor for consistent quality cellular products

Sartorius Stedim Biotech, a leading international supplier for the biopharmaceutical industry today announced the launch of the BIOSTAT RM TX single-use bioreactor, a new wave mixed system developed specifically for closed, automated expansion of consistent quality cell products such as ex vivo cellular immunotherapies.

From Sartorius 22 Jan 2019

Study takes a step closer to understanding the body's response to opioid painkillers

Researchers have taken a step closer to understanding the body's response to opioid painkillers such as morphine and fentanyl, which could lead to the development of safer opioid drugs.

21 Jan 2019

The brain's cerebellum plays role in controlling reward and social behaviors, study shows

A new study in rodents has shown that the brain's cerebellum--known to play a role in motor coordination--also helps control the brain's reward circuitry.

18 Jan 2019

New study determines the fate of DNA derived from genetically modified food

An international group of toxicologists, which includes scientists from Far Eastern Federal University, continues to study the potential risks of genetically modified products.

18 Jan 2019

Mutant mice administered with cocaine failed to exhibit hyperactivity, shows study

Cocaine is a highly addictive psychostimulant that induces complex molecular, cellular and behavioral responses. Despite various approaches and years of pre-clinical studies, effective, mechanism-based therapies to assist with cocaine misuse and dependence are still sorely lacking.

16 Jan 2019

TGF-beta signaling pathway in uterine cells protects against cancer

Two new mouse models of uterine cancer shed light on how this disease - the most common gynecological cancer in the U.S. - happens.

16 Jan 2019

Researchers identify MANF as a rejuvenating factor in parabiosis

Older mice who are surgically joined with young mice in order to share a common bloodstream get stronger and healthier, making parabiosis one of the hottest topics in age research. Publishing in Nature Metabolism, researchers from the Buck Institute report that MANF (mesencephalic astrocyte-derived neurotrophic factor) is one of the factors responsible for rejuvenating the transfused older mice.

16 Jan 2019

Measures of biochemical hypoglycemia linked to high risk of severe hypoglycemic events

Researchers have shown that measures of biochemical hypoglycemia in fingerstick blood samples are associated with an increased risk of severe hypoglycemic events.

10 Jan 2019

New findings bring about better understanding of many cancers' metabolic needs

Scientists at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have discovered that squamous cell skin cancers do not require increased glucose to power their development and growth, contrary to a long-held belief about cancer metabolism.

10 Jan 2019

Mice sleeping fitfully help unravel mystery of insomnia

Mice that sleep fitfully could help researchers unravel the mystery of insomnia. Researchers at Washington University School of Medicine in St. Louis studied mice genetically modified to mimic the genetic disease neurofibromatosis type 1, which is associated with sleep problems.

9 Jan 2019

Therapeutic implications of caffeine in neuropsychiatric disorders

An important new article reviews recently discovered properties of adenosine A2A receptor-dopamine D2 receptor and adenosine A1 receptor-dopamine D1 receptor heteromers--both of which are main targets for caffeine--and discusses the therapeutic implications of these findings.

7 Jan 2019

Cellular protein signal can be manipulated to favor bone building

In experiments in rats and human cells, Johns Hopkins Medicine researchers say they have added to evidence that a cellular protein signal that drives both bone and fat formation in selected stem cells can be manipulated to favor bone building.

7 Jan 2019

New, potential therapy can disrupt myeloid cells that promote tumor growth

Cancerous tumors trick myeloid cells, an important part of the immune system, into perceiving them as a damaged part of the body; the tumors actually put myeloid cells to work helping them grow and metastasize (spread).

7 Jan 2019

Scientists fix flawed plant genes, make plants grow 40% larger

Researchers in the US have genetically engineered a way of shortcutting photosynthesis to increase the size of tobacco plants by up to 40%.

4 Jan 2019

Senescent cells in the brain shown to cause obesity-related anxiety

Researchers have shown that obesity increases the level of semi-dormant senescent cells in the brain, which give rise to anxiety-like behaviors.

3 Jan 2019

Study reveals heart cell defect as possible cause of heart failure in pregnancy

Peripartum cardiomyopathy is a rare form of heart failure that affects women in their last month of pregnancy and up to five months after giving birth. PPCM can be difficult to detect because its symptoms -- swelling in the feet and legs and shortness of breath -- mimic many of those of third trimester pregnancy.

2 Jan 2019

Neuronal cell death in Alzheimer's disease may actually not be a bad thing, shows study

For the first time, scientists at the Champalimaud Centre for the Unknown, in Lisbon, Portugal, have shown that neuronal cell death in Alzheimer's disease may actually not be a bad thing - on the contrary, it may be the result of a cell quality control mechanism trying to protect the brain from the accumulation of malfunctioning neurons.

27 Dec 2018

Breast cancer drugs could tackle lung cancers resistant to targeted therapies

A class of drugs used to treat certain breast cancers could help to tackle lung cancers that have become resistant to targeted therapies, suggests a new study in mice from the Francis Crick Institute and the Institute of Cancer Research.

27 Dec 2018

Genetic Engineering News and Research

Injection of genetically modified virus effectively treats metastatic melanoma patients

Defective molecular master switch could lead to age-related macular degeneration

Sartorius launches BIOSTAT RM TX single-use bioreactor for consistent quality cellular products

Study takes a step closer to understanding the body's response to opioid painkillers

The brain's cerebellum plays role in controlling reward and social behaviors, study shows

New study determines the fate of DNA derived from genetically modified food

Mutant mice administered with cocaine failed to exhibit hyperactivity, shows study

TGF-beta signaling pathway in uterine cells protects against cancer

Researchers identify MANF as a rejuvenating factor in parabiosis

Measures of biochemical hypoglycemia linked to high risk of severe hypoglycemic events

New findings bring about better understanding of many cancers' metabolic needs

Mice sleeping fitfully help unravel mystery of insomnia

Therapeutic implications of caffeine in neuropsychiatric disorders

Cellular protein signal can be manipulated to favor bone building

New, potential therapy can disrupt myeloid cells that promote tumor growth

Scientists fix flawed plant genes, make plants grow 40% larger

Senescent cells in the brain shown to cause obesity-related anxiety

Study reveals heart cell defect as possible cause of heart failure in pregnancy

Neuronal cell death in Alzheimer's disease may actually not be a bad thing, shows study

Breast cancer drugs could tackle lung cancers resistant to targeted therapies

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