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Age-associated B cells found to be important drivers of lupus

A group of University of Pittsburgh researchers has given new meaning to "knowing your ABCs."

3 Mar 2023

Brain over-activation could be causing seizures and social deficits in genetic subtype of autism

Northwestern Medicine scientists have identified the cause of a genetic subtype of autism and schizophrenia that results in social deficits and seizures in mice and humans.

28 Feb 2023

Digital twins can lead to more personalized drug therapies for inflammatory diseases

Inflammatory diseases like rheumatoid arthritis have complex disease mechanisms that can differ from patient to patient with the same diagnosis.

28 Feb 2023

Head injuries may contribute to the development of glioma

Researchers from the UCL Cancer Institute have provided important molecular understanding of how injury may contribute to the development of a relatively rare but often aggressive form of brain tumor called a glioma.

24 Feb 2023

Synthetic hydrogels enable neuronal tissue growth in areas of brain damage

Synthetic hydrogels were shown to provide an effective scaffold for neuronal tissue growth in areas of brain damage, providing a possible approach for brain tissue reconstruction.

24 Feb 2023

First clinical trial of GABA/GAD focused exclusively on children with recent onset Type 1 diabetes

For the first time, humans with newly diagnosed Type 1 diabetes, or T1D, have received two treatments called GABA and GAD that have shown promise in animal studies and in isolated human pancreas islets. This investigator-initiated clinical trial, published in Nature Communications, focused exclusively on children with recent onset T1D.

22 Feb 2023

Research identifies potential treatment target for infantile spasms syndrome

New research from Tufts University School of Medicine and the Graduate School of Biomedical Sciences suggests that the timing of the death of certain inhibitory neurons in the brain shortly after birth may be at least partly to blame for infantile spasms syndrome (ISS), a rare but devastating form of epilepsy that develops most frequently between four and eight months of age but can emerge within weeks of birth until ages 4 or 5.

21 Feb 2023

Fetal cell program appears to protect against acute myeloid leukemia

During the fetal stage, a number of so-called cell programs run that are vital to the development of the fetus.

21 Feb 2023

Study indicates that macrophages that reside in the lymph nodes contribute to the initial Zika virus spread

Researchers mapped Zika virus infections in the lymph nodes to determine how the Zika virus enters from different points in the skin and disseminates through the body.

20 Feb 2023

UTHSC researchers secure $308,000 grant from Department of Defense for dementia study

Repeated traumatic brain injuries (TBI) in soldiers and military personnel can cause behavioral, neurological, and cognitive effects and lead to dementia.

19 Feb 2023

Researchers use the drug fasudil to reverse two key symptoms of schizophrenia

A team from Nagoya University in Japan used the drug fasudil to reverse two common symptoms associated with schizophrenia: reduced density of pyramidal neurons and cognitive dysfunction associated with methamphetamine treatment.

17 Feb 2023

Small molecule inhibitor reverses malignant hyper-editing by an inflammation-induced protein isoform

Researchers at University of California San Diego School of Medicine, Sanford Stem Cell Institute and Moores Cancer Center report that a late-stage, pre-clinical small molecule inhibitor, called rebecsinib, reverses malignant hyper-editing by an inflammation-induced protein isoform, known as ADAR1 p150.

16 Feb 2023

Mouse Model News and Research

Age-associated B cells found to be important drivers of lupus

Brain over-activation could be causing seizures and social deficits in genetic subtype of autism

Digital twins can lead to more personalized drug therapies for inflammatory diseases

Head injuries may contribute to the development of glioma

Synthetic hydrogels enable neuronal tissue growth in areas of brain damage

First clinical trial of GABA/GAD focused exclusively on children with recent onset Type 1 diabetes

Research identifies potential treatment target for infantile spasms syndrome

Fetal cell program appears to protect against acute myeloid leukemia

Study indicates that macrophages that reside in the lymph nodes contribute to the initial Zika virus spread

UTHSC researchers secure $308,000 grant from Department of Defense for dementia study

Researchers use the drug fasudil to reverse two key symptoms of schizophrenia

Small molecule inhibitor reverses malignant hyper-editing by an inflammation-induced protein isoform

Similar genes may lead to different patterns of fat distribution in women

Repurposing or improving drugs for spinocerebellar ataxia type 5

First successful correction of limb length in mouse model of autosomal dominant Robinow Syndrome

Migraine drug could be a potential treatment for acute kidney injury

B lymphocytes play a pivotal role in promoting an emergent response during infection

New mouse model demonstrates clear differences in virulence among mpox virus clades

New research could help explain how sense of smell is impacted in individuals with autism

The immunogenicity of two leading malaria vaccine candidates delivered as mRNA-LNP vaccines

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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