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Hopkins stem cell research to examine how gene variants cause blood clotting disorders

4 Aug 2011

Scientists look to create blood platelets from stem cells to study genetics of blood clotting disorders

Johns Hopkins scientists have launched a pioneering research program to create, for the first time, human platelet cells from stem cells in order to study inherited blood clotting abnormalities ranging from clots that cause heart attacks and stroke to bleeding disorders. The study is funded by a $9 million grant from the National Institutes of Health (NIH) as part of a nationwide initiative to examine how genetic variations cause heart, lung and blood diseases.

2 Aug 2011

Researchers identify elusive gene responsible for Grey Platelet Syndrome

Researchers have identified an elusive gene responsible for Grey Platelet Syndrome, an extremely rare blood disorder in which only about 50 known cases have been reported. As a result, it is hoped that future cases will be easier to diagnose with a DNA test.

26 Jul 2011

FDA approves U.S. launch of Wiskott-Aldrich gene therapy clinical trial

The U.S. Food & Drug Administration (FDA) approved the launching in the U.S. of a clinical trial for gene therapy for a rare immunodeficiency, Wiskott-Aldrich syndrome.

22 Jul 2011

AstraZeneca receives FDA approval for BRILINTA to treat acute coronary syndrome

AstraZeneca announced today that the US Food and Drug Administration (FDA) has approved BRILINTA (ticagrelor) tablets to reduce the rate of heart attack and cardiovascular (CV) death in adult patients with acute coronary syndrome (ACS), compared to clopidogrel.

21 Jul 2011

Stopping Aspirin may raise heart attack death risk by 60%: Study

The study results revealed that patients with a history of heart disease who stopped taking a low-dose daily aspirin had a 60% increased risk of having a heart attack over the three-year follow-up, compared with patients who continued the daily aspirin, says study researcher Luis A. Garcia Rodriguez, director of the Spanish Center for Pharmacoepidemiologic Research (CEIFE) in Madrid. The study is published in the British Medical Journal.

20 Jul 2011

American Red Cross acquires HemaCare's red blood cell collection operation assets

HemaCare Corporation announced today that it has reached a definitive agreement to sell certain assets of its Blood Services operations to the American Red Cross. Under the terms of the sale, which closed today, HemaCare sold its red blood cell collection operation assets to the American Red Cross. The sale does not include HemaCare's platelet collection business.

11 Jul 2011

Pregnant women face higher risk of stroke

High blood pressure during pregnancy is a leading cause of maternal and fetal mortality worldwide.

8 Jul 2011

Acetylon to advance ACY-1215 drug candidate with $27M Series B Preferred equity investment round of financing

Acetylon Pharmaceuticals, Inc. announced today that it has completed a $27 million Series B Preferred equity investment round of financing.

29 Jun 2011

Ticagrelor drug with low-dose aspirin effective against acute coronary syndrome

When taken with higher doses of aspirin, the experimental antiplatelet drug ticagrelor was associated with worse outcomes than the standard drug, clopidogrel, but the opposite was true with lower doses of aspirin.

28 Jun 2011

Angioplasty may be an option for liver transplant candidates with heart disease

A small, retrospective study determined that percutaneous coronary intervention (PCI) was safe in patients with significant coronary artery disease (CAD) who were referred for liver transplantation. Larger studies are needed to determine the effectiveness of angioplasty in patients with end-stage liver disease (ESLD). Details of the study are available in the July issue of Liver Transplantation, published by Wiley-Blackwell on behalf of the American Association for the Study of Liver Diseases.

22 Jun 2011

Study finds PCI safe and feasible option for End-Stage Liver Disease patients with significant heart disease

22 Jun 2011

Celerion generates over 25,000 platelet aggregation samples, achieves major milestone

Celerion, the premier provider of innovative early stage drug development solutions, announces it has achieved a major milestone of generating over 25,000 platelet aggregation sample results.

22 Jun 2011

Positive results from LCP-Tacro Phase III trial in stable kidney transplant recipients

LifeCycle Pharma A/S today reported that the company's lead product candidate, LCP-Tacro, successfully demonstrated non-inferiority compared to tacrolimus in its Phase III trial, Study 3001.

21 Jun 2011

Platelet Derived Growth Factor Receptor-beta plays key role in onset of obesity

A new study from Mount Sinai School of Medicine has found that a cellular signaling pathway governs the differentiation of cells into fat tissue or smooth muscle, which lines the vascular system. Engaging this signaling pathway and its capacity to govern cell differentiation has important implications in preventing obesity and cardiovascular disease.

16 Jun 2011

Saint-Gobain introduces new C-Flex ULTRA TPE pump tubing for biopharmaceutical applications

Saint-Gobain Performance Plastics has expanded its line of thermoplastic elastomer (TPE) tubing with the addition of new C-Flex® ULTRA pump tubing, a product designed specifically to perform in demanding biopharmaceutical applications such as pumping, single-use assemblies, process filling and sampling.

15 Jun 2011

ESC publishes position paper to raise the profile of vulnerable plaques

The European Society of Cardiology (ESC) Working Group of Atherosclerosis and Vascular Biology has published a position paper to raise the profile of vulnerable plaques and the need for greater use of therapies to promote plaque stabilisation.

15 Jun 2011

Liver stiffness measurement could replace liver biopsy for evaluation of hepatitis C

Non-invasive tests for liver fibrosis, such as liver stiffness measurement or the FibroTest, can predict survival of patients with chronic hepatitis C, according to a new study in Gastroenterology, the official journal of the American Gastroenterological Association (AGA) Institute.

15 Jun 2011

Astellas, Ambit Biosciences announce interim results from AC220 Phase 2 trial against AML

Ambit Biosciences Corporation and Astellas Pharma Inc. announced today results from a planned interim analysis in an ongoing Phase 2 study evaluating AC220, a potent and selective FLT3 inhibitor.

14 Jun 2011

Final data from Alexion's Soliris Phase 2 studies on aHUS presented at EHA 2011

Alexion Pharmaceuticals, Inc. today announced the presentation of final data from the two Phase 2 studies of Soliris as a treatment for patients with atypical hemolytic uremic syndrome.

13 Jun 2011

Platelet News and Research

Hopkins stem cell research to examine how gene variants cause blood clotting disorders

Scientists look to create blood platelets from stem cells to study genetics of blood clotting disorders

Researchers identify elusive gene responsible for Grey Platelet Syndrome

FDA approves U.S. launch of Wiskott-Aldrich gene therapy clinical trial

AstraZeneca receives FDA approval for BRILINTA to treat acute coronary syndrome

Stopping Aspirin may raise heart attack death risk by 60%: Study

American Red Cross acquires HemaCare's red blood cell collection operation assets

Pregnant women face higher risk of stroke

Acetylon to advance ACY-1215 drug candidate with $27M Series B Preferred equity investment round of financing

Ticagrelor drug with low-dose aspirin effective against acute coronary syndrome

Angioplasty may be an option for liver transplant candidates with heart disease

Study finds PCI safe and feasible option for End-Stage Liver Disease patients with significant heart disease

Celerion generates over 25,000 platelet aggregation samples, achieves major milestone

Positive results from LCP-Tacro Phase III trial in stable kidney transplant recipients

Platelet Derived Growth Factor Receptor-beta plays key role in onset of obesity

Saint-Gobain introduces new C-Flex ULTRA TPE pump tubing for biopharmaceutical applications

ESC publishes position paper to raise the profile of vulnerable plaques

Liver stiffness measurement could replace liver biopsy for evaluation of hepatitis C

Astellas, Ambit Biosciences announce interim results from AC220 Phase 2 trial against AML

Final data from Alexion's Soliris Phase 2 studies on aHUS presented at EHA 2011

Industry Focus eBook - Neurology/Neuroscience - 2nd edition eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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