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Freiburg researchers discover molecule that smuggles toxins from intestinal pathogens into human cells

Prof. Dr. Dr. Klaus Aktories and Dr. Panagiotis Papatheodorou from the Institute of Experimental and Clinical Pharmacology and Toxicology of the University of Freiburg have discovered the receptor responsible for smuggling the toxin of the bacterium Clostridium perfringens into the cell.

17 Apr 2014

Researchers coax human embryonic stem cells to turn into working spinal cord cells

The sponginess of the environment where human embryonic stem cells are growing affects the type of specialized cells they eventually become, a University of Michigan study shows.

16 Apr 2014

Researchers identify experimental drugs to block treatment-resistant leukemia

Research in mice and human cell lines has identified an experimental compound dubbed TTT-3002 as potentially one of the most potent drugs available to block genetic mutations in cancer cells blamed for some forms of treatment-resistant leukemia.

9 Apr 2014

Research provides new approach to developing better treatment options for scleroderma

Scleroderma is a rare and often fatal disease, causing the thickening of tissue, that currently lacks a cure and any effective treatments. A group of researchers, including a Michigan State University professor, is looking to change that.

7 Apr 2014

Personalized treatment approach may benefit patients with common breast cancer subtype

The second-most common type of breast cancer is a very different disease than the most common and appears to be a good candidate for a personalized approach to treatment, according to a multidisciplinary team led by scientists at the University of Pittsburgh Cancer Institute (UPCI), a partner with UPMC CancerCenter.

7 Apr 2014

NCCN ORP awarded grant to study effectiveness of enzalutamide in solid tumors

The National Comprehensive Cancer Network Oncology Research Program has been awarded a $2.2-million grant from Astellas Pharma, Inc. and Medivation, Inc. to develop a program to scientifically evaluate and define the clinical effectiveness of enzalutamide in solid tumors, including bladder, breast, endometrial, hepatocellular, ovarian, and prostate cancers.

1 Apr 2014

Findings reveal potential drug targets for small cell lung cancer

Cancer cells undergo extensive genetic alterations as they grow and spread through the body. Some of these mutations, known as "drivers," help spur cells to grow out of control, while others ("passengers") are merely along for the ride.

17 Mar 2014

UC Davis MIND Institute named Intellectual and Developmental Disabilities Research Center

The UC Davis MIND Institute has been named an Intellectual and Developmental Disabilities Research Center, through a prestigious grant from the Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health - a distinction held by only a handful of neurodevelopmental centers nationwide committed to the diagnosis, prevention, treatment and amelioration of developmental disorders such as autism, fragile X syndrome and Down syndrome.

14 Mar 2014

Patient with advanced bladder cancer shows complete response to everolimus and pazopanib drugs

A patient with advanced bladder cancer experienced a complete response for 14 months to the drug combination everolimus and pazopanib in a phase I trial, and genomic profiling of his tumor revealed two alterations that may have caused this exceptional response, according to a study published in Cancer Discovery, a journal of the American Association for Cancer Research.

13 Mar 2014

Study provides insight into the mechanisms underlying diabetic peripheral neuropathy

Iron overload can lead to cytotoxicity, and it is a risk factor for diabetic peripheral neuropathy. However, the underlying mechanism remains unclear.

13 Mar 2014

Researchers examine role of alpha-synuclein in neuronal cells

Alpha-synuclein is a principal component of Lewy bodies and Lewy neurites, which are pathologic hall-marks of Parkinson's disease. Alpha-synuclein is generally considered to play a role in synaptic activity, although its function remains largely unknown.

13 Mar 2014

Protein interaction network provides invaluable resource to identify targets for Huntington's disease

Researchers at the Buck Institute have identified and categorized thousands of protein interactions involving huntingtin, the protein responsible for Huntington's disease (HD). To use an analogy of a human social network, the identified proteins are like "friends" and "friends of friends" of the HD protein.

28 Feb 2014

UH scientists working to develop next generation of prostate cancer therapies

A University of Houston scientist and his team are working to develop the next generation of prostate cancer therapies, which are targeted at metabolism.

27 Feb 2014

Certain fragments of DNA shed by tumors can be used to non-invasively screen for early-stage cancers

Certain fragments of DNA shed by tumors into the bloodstream can potentially be used to non-invasively screen for early-stage cancers, monitor responses to treatment and help explain why some cancers are resistant to therapies, according to results of an international study led by Johns Hopkins Kimmel Cancer Center investigators.

20 Feb 2014

Researchers detail how psoralen blocks signaling pathway of HER2-positive cancers

A common compound known to fight lymphoma and skin conditions actually has a second method of action that makes it particularly deadly against certain aggressive breast tumors, researchers at Duke Medicine report.

18 Feb 2014

Study points to unique therapeutic approach for managing muscle-wasting conditions

New findings on why skeletal muscle stem cells stop dividing and renewing muscle mass during aging points up a unique therapeutic opportunity for managing muscle-wasting conditions in humans, says a new University of Colorado Boulder study.

17 Feb 2014

Scientists explain why women with dense breast tissue at greater risk of developing breast cancer

Scientists from The University of Manchester working with IBM Research have identified a key biological mechanism that for the first time explains why women with dense breast tissue are at greater risk of developing breast cancer.

12 Feb 2014

Two oncogenes work together to sustain population of cells in lung squamous cell carcinoma

Patients with a common form of lung cancer — lung squamous cell carcinoma — have very few treatment options. That situation may soon change.

10 Feb 2014

Researchers discover new signaling pathway that could impact treatment of autoinflammatory diseases

Researchers from Virginia Commonwealth University (VCU) Massey Cancer Center have discovered a new signaling pathway in sterile inflammation that could impact the treatment of diseases such as cancer, multiple sclerosis and rheumatoid arthritis.

4 Feb 2014

Researchers identify protein critical to hematopoietic stem cell function, blood formation

Researchers at the University of California, San Diego School of Medicine have identified a protein critical to hematopoietic stem cell function and blood formation. The finding has potential as a new target for treating leukemia because cancer stem cells rely upon the same protein to regulate and sustain their growth.

3 Feb 2014

Signaling Pathway News and Research

Freiburg researchers discover molecule that smuggles toxins from intestinal pathogens into human cells

Researchers coax human embryonic stem cells to turn into working spinal cord cells

Researchers identify experimental drugs to block treatment-resistant leukemia

Research provides new approach to developing better treatment options for scleroderma

Personalized treatment approach may benefit patients with common breast cancer subtype

NCCN ORP awarded grant to study effectiveness of enzalutamide in solid tumors

Findings reveal potential drug targets for small cell lung cancer

UC Davis MIND Institute named Intellectual and Developmental Disabilities Research Center

Patient with advanced bladder cancer shows complete response to everolimus and pazopanib drugs

Study provides insight into the mechanisms underlying diabetic peripheral neuropathy

Researchers examine role of alpha-synuclein in neuronal cells

Protein interaction network provides invaluable resource to identify targets for Huntington's disease

UH scientists working to develop next generation of prostate cancer therapies

Certain fragments of DNA shed by tumors can be used to non-invasively screen for early-stage cancers

Researchers detail how psoralen blocks signaling pathway of HER2-positive cancers

Study points to unique therapeutic approach for managing muscle-wasting conditions

Scientists explain why women with dense breast tissue at greater risk of developing breast cancer

Two oncogenes work together to sustain population of cells in lung squamous cell carcinoma

Researchers discover new signaling pathway that could impact treatment of autoinflammatory diseases

Researchers identify protein critical to hematopoietic stem cell function, blood formation

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