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Overlap in pro-inflammatory genes and pathways between COVID-19 and MIS-C

In a recent study posted to the medRxiv* pre-print server, researchers in the United States characterized differential host immune responses in acute coronavirus disease 2019 (COVID-19) and multisystem inflammatory syndrome in children (MIS-C) to inform future development of novel biomarkers for both diseases.

23 Jun 2022

Mild COVID causes increase in neurotoxic metabolites

In a recent study posted to the bioRxiv* pre-print server, researchers investigated the blood levels of neurotoxic metabolites in patients with mild coronavirus disease 2019 (COVID-19).

23 Jun 2022

"Founder events" that reduced genetic diversity found to be common throughout human history

Human populations have waxed and waned over the millennia, with some cultures exploding and migrating to new areas or new continents, others dropping to such low numbers that their genetic diversity plummeted.

23 Jun 2022

Fragment crystallizable-altered COVID-19 antibodies efficacious across two animal models

A recent article posted to the bioRxiv* preprint server identified numerous efficacious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies from convalescent SARS-CoV-2 patients.

23 Jun 2022

Bacterium discovery helps to solve the puzzle of what factors limit cell size

On sunken leaves in the waters of a Caribbean mangrove swamp, researchers discovered a bacterium that challenges the prevailing view of bacterial cell size; counter to the notion that microbes are only visible with a microscope, this one – named Thiomargarita magnifica – is larger than all other known giant bacteria by ~50-fold, and can be seen by the naked eye, the study's authors say.

23 Jun 2022

New method helps unravel three-dimensional structure of the human genome

Weill Cornell Medicine and New York Genome Center researchers, in collaboration with Oxford Nanopore Technologies, have developed a new method to assess on a large scale the three-dimensional structure of the human genome, or how the genome folds.

23 Jun 2022

Researchers continue a national study to evaluate COVID-19 vaccination safety pre-and post-delivery

With the SARS-CoV-2 pandemic ongoing, researchers at University of California San Diego School of Medicine, in collaboration with the American Academy of Allergy Asthma and Immunology, will continue a national study to evaluate the safety of COVID-19 vaccinations during pregnancy, and monitor immune response for mother and baby following vaccinations.

23 Jun 2022

New report estimates cancer prevalence in the U.S. and provides survivorship statistics

A new report led by researchers at the American Cancer Society in collaboration with the National Cancer Institute shows more than 18 million Americans (8.3 million males and 9.7 million females) with a history of cancer were living in the United States as of January 1, 2022, with a little over 12 million (67%) aged 65 years or older.

23 Jun 2022

Study unveils a precise model for the stinging organelle of starlet sea anemone

Summertime beachgoers are all too familiar with the painful reality of a jellyfish sting. But how do the stinging cells of jellyfish and their coral and sea anemone cousins actually work? New research from the Stowers Institute for Medical Research unveils a precise operational model for the stinging organelle of the starlet sea anemone, Nematostella vectensis.

23 Jun 2022

Molecular tumor profiling in pediatric cancer patients significantly impacts clinical care

Results of a study of molecular tumor profiling in young patients revealed a high rate of genetic alterations with potential for impacting clinical care, including clarifying diagnoses and treatment with matched, precision cancer drugs.

23 Jun 2022

Novel liquid biopsy test can quickly identify cancer DNA in patients with metastatic breast cancer

A novel, automated liquid biopsy test in development by researchers at the Johns Hopkins Kimmel Cancer Center can accurately detect the presence of cancer DNA in the blood of patients with metastatic breast cancer within five hours.

23 Jun 2022

U-M researchers reveal how a mutated protein acts as risk factor in Parkinson’s disease

In about a fifth of the cases of Parkinson’s disease, look to a small, malfunctioning protein in the lysosome as a risk factor, say University of Michigan researchers.

23 Jun 2022

Researchers discover two important novel aspects of APOE4 gene in Alzheimer's patients

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia, affecting more than 5.8 million individuals in the U.S.

23 Jun 2022

Researchers model a complex childhood disease on-a-chip

Millions of children in low- and middle-income nations suffer from environmental enteric dysfunction (EED), a chronic inflammatory disease of the intestine that is the second leading cause of death in children under five years old.

23 Jun 2022

Listeria-based booster vaccine strategy offers improved protection against recurrent colorectal cancer

Colorectal, pancreatic, esophageal and stomach cancers - some of the deadliest kinds of cancer - have high recurrence rates where the cancer comes back even after successful surgery or radiation treatment.

23 Jun 2022

Mutation in SARS-CoV-2 nucleocapsid protein found to enhance replication and pathogenicity

Researchers investigated a highly variable region at residues 203 to 205 in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleocapsid (N) protein.

23 Jun 2022

Analyzing biophysical restrictions of SARS-CoV-2 N-terminal domain

In a recent article posted to the bioRxiv* preprint server, researchers at the University of Illinois at Urbana-Champaign, Scripps Research Institute, and Case Western Reserve University evaluated the biophysical limitations of the spike (S) N-terminal domain (NTD) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

23 Jun 2022

SARS-CoV-2 evades natural killer cell cytotoxic responses

In a recent study posted to the bioRxiv* preprint server, researchers at Stanford University School of Medicine revealed the mechanism via severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) escapes natural killer (NK) cell cytotoxic reactions.

22 Jun 2022

Study provides better understanding of the brain pathways that control nausea

Nausea is a bit of a catchall sensation for the human body: the unpleasant sick feeling can hit us as a result of everything from pregnancy or a migraine to eating spoiled food or undergoing chemotherapy.

22 Jun 2022

Immune and central nervous systems may play a key role in ALS, Mount Sinai researchers report

The immune system may play a fundamental role along with the central nervous system in amyotrophic lateral sclerosis (ALS), also known as "Lou Gehrig's disease," Mount Sinai researchers report.

22 Jun 2022

B Cell News and Research

Overlap in pro-inflammatory genes and pathways between COVID-19 and MIS-C

Mild COVID causes increase in neurotoxic metabolites

"Founder events" that reduced genetic diversity found to be common throughout human history

Fragment crystallizable-altered COVID-19 antibodies efficacious across two animal models

Bacterium discovery helps to solve the puzzle of what factors limit cell size

New method helps unravel three-dimensional structure of the human genome

Researchers continue a national study to evaluate COVID-19 vaccination safety pre-and post-delivery

New report estimates cancer prevalence in the U.S. and provides survivorship statistics

Study unveils a precise model for the stinging organelle of starlet sea anemone

Molecular tumor profiling in pediatric cancer patients significantly impacts clinical care

Novel liquid biopsy test can quickly identify cancer DNA in patients with metastatic breast cancer

U-M researchers reveal how a mutated protein acts as risk factor in Parkinson’s disease

Researchers discover two important novel aspects of APOE4 gene in Alzheimer's patients

Researchers model a complex childhood disease on-a-chip

Listeria-based booster vaccine strategy offers improved protection against recurrent colorectal cancer

Mutation in SARS-CoV-2 nucleocapsid protein found to enhance replication and pathogenicity

Analyzing biophysical restrictions of SARS-CoV-2 N-terminal domain

SARS-CoV-2 evades natural killer cell cytotoxic responses

Study provides better understanding of the brain pathways that control nausea

Immune and central nervous systems may play a key role in ALS, Mount Sinai researchers report

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