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High-intensity walking exercise benefits people with peripheral artery disease

No pain means no gain when it comes to reaping exercise benefits for people with peripheral artery disease (PAD), reports a new Northwestern Medicine study.

6 Apr 2021

$10.8 million grant from NIH helps establish Arkansas Integrative Metabolic Research Center

A $10.8 million grant from the National Institutes of Health will enable an interdisciplinary team of researchers at the University of Arkansas and University of Arkansas for Medical Sciences to address the role of cell and tissue metabolism in rare and common diseases such as cancer, diabetes, obesity and mitochondrial disorders.

6 Apr 2021

Tissue architecture impacts the evolutionary course of cancer

Tumors are genetically diverse with different mutations arising at different times throughout growth and development.

6 Apr 2021

Researchers evaluate new drug for spinal muscular atrophy in a broader spectrum of patients

The rarity of spinal muscular atrophy (SMA) means that promising new treatments may be tested in only a limited spectrum of patients before approval. Investigators evaluated a newly approved drug, onasemnogene abeparvovec, in a broader spectrum of patients in order to obtain expanded data on its side effects profile.

6 Apr 2021

UCL scientists use AI to identify three new multiple sclerosis subtypes

Scientists at UCL have used artificial intelligence (AI) to identify three new multiple sclerosis (MS) subtypes. Researchers say the groundbreaking findings will help identify those people more likely to have disease progression and help target treatments more effectively.

6 Apr 2021

World's first human tracheal transplant performed by Mount Sinai surgeons

A team of Mount Sinai surgeons has performed the world's first human tracheal transplant--an achievement that has the potential to save the lives of thousands of patients around the world who have tracheal birth defects, untreatable airway diseases, burns, tumors, or severe tracheal damage from intubation, including those who had been hospitalized with COVID-19 and placed on a ventilator.

6 Apr 2021

Researchers define genetic landscape of uterine leiomyosarcomas

In a new study, Yale Cancer Center researchers have defined the genetic landscape of uterine leiomyosarcomas (uLMS).

6 Apr 2021

Research explores sex differences in placental defenses against SARS-CoV-2 infection

A plethora of earlier studies has reported on the differences between the sexes in susceptibility to the currently circulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), as well as its severity. A new preprint research paper posted to the bioRxiv* server extends this to the placenta in pregnancy.

6 Apr 2021

Oncogenic RAS mutations are responsible for regrowth of cancer cells following genotoxic therapies

In the fight against cancers, activating mutations in the RAS family of genes stand in the way of finding viable treatment options.

6 Apr 2021

New exosome-coated stent repairs damaged tissue, heals vascular injury

Researchers from North Carolina State University have developed an exosome-coated stent with a "smart-release" trigger that could both prevent reopened blood vessels from narrowing and deliver regenerative stem cell-derived therapy to blood-starved, or ischemic, tissue.

6 Apr 2021

New approach to CAR T gene therapy yields efficient and longer-lasting response against HIV

A UCLA research team has shown that using a truncated form of the CD4 molecule as part of a gene therapy to combat HIV yielded superior and longer-lasting results in mouse models than previous similar therapies using the CD4 molecule.

3 Apr 2021

Treatment resistance in triple-negative breast cancers linked to softer tissue environment

Researchers at the University of California, San Francisco, have discovered that aggressive, triple-negative breast cancers (TNBCs) can evade treatment by reorganizing and softening the collagen matrix that surrounds the cancer cells.

3 Apr 2021

Combination of tumor cell vaccine and checkpoint therapy creates effective immune response

A personalized tumor cell vaccine strategy targeting Myc oncogenes combined with checkpoint therapy creates an effective immune response that bypasses antigen selection and immune privilege, according to a pre-clinical study for neuroblastoma and melanoma.

3 Apr 2021

American College of Cardiology offers new EP Device Implant Registry

Effective immediately, the American College of Cardiology is offering the EP Device Implant Registry, which will include data on ICD and CRT-D procedures previously captured in the NCDR ICD Registry as well as provide the flexibility to capture novel pacemaker procedures.

3 Apr 2021

Research offers new clues about the underlying mechanisms of itch

Eczema, or atopic dermatitis (AD), is sometimes called "the itch that rashes." Often, the itch begins before the rash appears, and, in many cases, the itchiness of the skin condition never really goes away.

3 Apr 2021

Study explores long-term outcomes and costs of non-muscle invasive bladder cancer

A new research study leveraging a database from the largest equal access health system in the US, the Department of Veteran Affairs, offers insight into the outcome of specific treatment patterns for advanced bladder cancer patients.

2 Apr 2021

Changing diet and exercise can make chemotherapy more effective in youth with leukemia

Overweight children and adolescents receiving chemotherapy for treatment of leukemia are less successful battling the disease compared to their lean peers.

1 Apr 2021

Stem cell transplants offer long-term benefits for pediatric cancer patients receiving immunotherapy

Children and young adults who receive CAR T-cell therapy for the most common childhood cancer - acute lymphoblastic leukemia - suffer remarkably fewer relapses and are far more likely to survive when the treatment is paired with a subsequent stem cell transplant, a new study finds.

1 Apr 2021

New update addresses key issues in the delivery of sleep care using telemedicine

The American Academy of Sleep Medicine recently published an update on the use of telemedicine for the diagnosis and treatment of sleep disorders to reflect lessons learned from the transition to telemedicine during the COVID-19 pandemic and the benefits of continuing to utilize remote care when appropriate.

1 Apr 2021

Single injection of RNA therapy improves vision in patient with genetic form of childhood blindness

A Penn Medicine patient with a genetic form of childhood blindness gained vision, which lasted more than a year, after receiving a single injection of an experimental RNA therapy into the eye.

1 Apr 2021

Therapy News and Research

High-intensity walking exercise benefits people with peripheral artery disease

$10.8 million grant from NIH helps establish Arkansas Integrative Metabolic Research Center

Tissue architecture impacts the evolutionary course of cancer

Researchers evaluate new drug for spinal muscular atrophy in a broader spectrum of patients

UCL scientists use AI to identify three new multiple sclerosis subtypes

World's first human tracheal transplant performed by Mount Sinai surgeons

Researchers define genetic landscape of uterine leiomyosarcomas

Research explores sex differences in placental defenses against SARS-CoV-2 infection

Oncogenic RAS mutations are responsible for regrowth of cancer cells following genotoxic therapies

New exosome-coated stent repairs damaged tissue, heals vascular injury

New approach to CAR T gene therapy yields efficient and longer-lasting response against HIV

Treatment resistance in triple-negative breast cancers linked to softer tissue environment

Combination of tumor cell vaccine and checkpoint therapy creates effective immune response

American College of Cardiology offers new EP Device Implant Registry

Research offers new clues about the underlying mechanisms of itch

Study explores long-term outcomes and costs of non-muscle invasive bladder cancer

Changing diet and exercise can make chemotherapy more effective in youth with leukemia

Stem cell transplants offer long-term benefits for pediatric cancer patients receiving immunotherapy

New update addresses key issues in the delivery of sleep care using telemedicine

Single injection of RNA therapy improves vision in patient with genetic form of childhood blindness

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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