Protein C News and Research

RSS

Study identifies mechanism of resistance and presents a much-needed target for advanced leukemias

Too many "exhausted" T cells left in the wake of aggressive chemotherapy regimens for patients with advanced chronic lymphocytic leukemia (CLL) make it more challenging for chimeric antigen receptor (CAR) T cell therapy to do its job.

16 Aug 2021

Obtained SARS-CoV-2 immunity, naturally or via vaccination persists 12 months

In a research paper recently uploaded to the preprint server medRxiv* by Havervall et al. (August 12th, 2021), neutralizing antibody titers towards wild-type SARS-CoV-2 and several variants of concern in individuals having either been vaccinated or infected with mild COVID-19 one year earlier are assessed, finding a reduced neutralization capacity against some strains.

16 Aug 2021

Response to a third SARS-CoV-2 vaccine dose amongst immunocompromised

In a research paper recently uploaded to the preprint server medRxiv* by Schrezenmeier et al. (August 12th, 2021) the potential benefit of three vaccine doses in either a homogenous or heterogeneous dosing regimen amongst kidney transplant patients is assessed, finding that the search for viable vaccination approaches amongst these patients remains an urgent medical need.

16 Aug 2021

Researchers assess the genetic features of T-cell immunity development to SARS-CoV-2 variants

The continuing emergence of new SARS-CoV-2 mutations allows the virus to spread more effectively and evade antibodies. However, it is unclear whether new strains are capable of evading T-cell immunity - one of the body's main lines of defense against COVID-19.

16 Aug 2021

SARS-CoV-2 Spike may trigger production of antibodies that cross-react with human thrombopoietin to induce thrombocytopenia

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infected individuals often suffer from thrombocytopenia, a condition associated with low platelet counts. The cytokine thrombopoietin regulates platelet count. Previous studies have reported that thrombocytopenia can increase the coronavirus disease 2019 (COVID-19) mortality rate by about five times.

16 Aug 2021

Research suggests toll-like receptor 4 appears to play role in severe COVID

A group of researchers re-evaluated their previously proposed hypothesis, which stated that the TLR4 activated by the spike glycoprotein S1 domain increases ACE2 expression and, thereby, aids in COVID-19 infection.

16 Aug 2021

Certain intestinal bacteria induce cross-reactive IgA responses to the SARS-CoV-2 spike RBD

A new study finds that human gut bacteria can induce antibodies of the immunoglobulin A (IgA) subtype that cross-react with the SARS-CoV-2 spike RBD.

15 Aug 2021

World-first trial of third dose COVID-19 booster vaccine shows improved protection in transplant patients

Scientists with the Ajmera Transplant Centre at UHN have conducted a first-in-the-world randomized placebo-controlled trial of third dose COVID-19 booster vaccine for transplant patients that shows substantially improved protection.

14 Aug 2021

Enzyme acts as a sensor to find the hiding spots of viruses

While some types of RNA viruses cloak themselves to hide inside a cell and create copies of themselves, a "detective enzyme" might be attuned to their whereabouts. A slight variation in their genomic code gives some people's cells the capacity to produce this sensor.

14 Aug 2021

Study illuminates the link between cholesterol and Alzheimer's-associated toxic protein clumps

A team co-led by scientists at Scripps Research has used advanced imaging methods to reveal how the production of the Alzheimer's-associated protein amyloid beta (Aβ) in the brain is tightly regulated by cholesterol.

13 Aug 2021

Researchers develop new method to quantify protein droplets involved in neurodegenerative diseases

Some proteins in cells can separate into small droplets like oil droplets in water, but faults in this process may underlie neurodegenerative diseases in the brains of older people. Now, Rutgers researchers have developed a new method to quantify protein droplets involved in these diseases.

13 Aug 2021

Structure of BRCA2 protein complex critical for DNA repair solved

The initials BRCA2 may be best known for a gene associated with many cases of breast cancer, and the protein encoded by the BRCA2 gene is critical to repairing breaks in DNA.

13 Aug 2021

L452R mutations may have triggered the emergence of several COVID-19 variants

Most of the recently risen coronavirus variants of interest or concern -- delta, kappa, epsilon, iota and lambda -- are universally carrying a mutation in amino acid L452 of the Spike protein that helps the virus bind to host cells.

13 Aug 2021

Novel CRISPR-based technique could inspire a new class of medical diagnostics

Scientists have repurposed the genetic modification technology CRISPR to identify antibodies in patient blood samples in a move that could inspire a new class of medical diagnostics in addition to a host of other applications.

13 Aug 2021

Study uncovers a subset of human short introns spliced out by a distinct mechanism

The interrupted non-coding regions in pre-mRNAs, termed “introns,” are excised by “splicing” to generate mature coding mRNAs that are translated into proteins.

13 Aug 2021

Researchers identify genetic program in fruit fly that protects neurons from degeneration

Researchers at the University of Bonn have identified a previously unknown genetic program in the fruit fly. The genetic material involved controls the development of the neurons while also protecting them from degeneration.

13 Aug 2021

Discovery of highly potent neutralizing monoclonal antibodies against SARS-CoV-2

A new study published in the journal Nature Communications has reported two neutralizing antibodies, namely, nCoVmab1 and nCoVmab2, which are potent against SARS-CoV-2.

13 Aug 2021

How replication and recombination contribute to emergence of SARS-CoV-2 variants

The coronavirus disease 2019 (COVID-19) pandemic has been caused by the rapid outbreak of a novel coronavirus, namely, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). SARS-CoV-2 was first reported in late December 2019 in Wuhan, China. Since then, the virus has already claimed more than 4.3 million lives worldwide.

13 Aug 2021

Advances in plant-made vaccines revive interest in plant-produced pharmaceuticals and edible drugs

Recent progress in developing and testing plant-made vaccines has revived interest in plant-produced pharmaceuticals, including edible drugs, for human use. Advances in technology and manufacturing could boost the uptake of therapeutics made in this way, say Hugues Fausther-Bovendo and Gary Kobinger in this Perspective.

13 Aug 2021

SARS-CoV-2 variants containing L452R spike mutation more resistant to antibody-mediated neutralization

A team of scientists from Frankfurt, Germany, has recently explored the efficacy of vaccine- or infection-induced antibodies and therapeutic monoclonal antibodies in neutralizing kappa and delta variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

12 Aug 2021

Protein C News and Research

Study identifies mechanism of resistance and presents a much-needed target for advanced leukemias

Obtained SARS-CoV-2 immunity, naturally or via vaccination persists 12 months

Response to a third SARS-CoV-2 vaccine dose amongst immunocompromised

Researchers assess the genetic features of T-cell immunity development to SARS-CoV-2 variants

SARS-CoV-2 Spike may trigger production of antibodies that cross-react with human thrombopoietin to induce thrombocytopenia

Research suggests toll-like receptor 4 appears to play role in severe COVID

Certain intestinal bacteria induce cross-reactive IgA responses to the SARS-CoV-2 spike RBD

World-first trial of third dose COVID-19 booster vaccine shows improved protection in transplant patients

Enzyme acts as a sensor to find the hiding spots of viruses

Study illuminates the link between cholesterol and Alzheimer's-associated toxic protein clumps

Researchers develop new method to quantify protein droplets involved in neurodegenerative diseases

Structure of BRCA2 protein complex critical for DNA repair solved

L452R mutations may have triggered the emergence of several COVID-19 variants

Novel CRISPR-based technique could inspire a new class of medical diagnostics

Study uncovers a subset of human short introns spliced out by a distinct mechanism

Researchers identify genetic program in fruit fly that protects neurons from degeneration

Discovery of highly potent neutralizing monoclonal antibodies against SARS-CoV-2

How replication and recombination contribute to emergence of SARS-CoV-2 variants

Advances in plant-made vaccines revive interest in plant-produced pharmaceuticals and edible drugs

SARS-CoV-2 variants containing L452R spike mutation more resistant to antibody-mediated neutralization

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Latest News