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Fear and isolation drives PTSD among health/social workers in COVID-19

A new study, published on the preprint server medRxiv* in October 2020, identifies the factors that predict distress in HSCW and emphasizes the importance of adequate supplies of personal protective equipment (PPE).

27 Oct 2020

Genome-wide screens reveal new helpful and harmful COVID-19 related genes

Researchers at Yale University and the Broad Institute of MIT and Harvard screened hundreds of millions of cells exposed to the COVID-19 and MERS viruses and identified dozens of genes that both enable the viruses to replicate in cells and also those that seem to slam the door on the virus.

27 Oct 2020

Scientists identify new target for developing novel drugs against several types of cancer

The Bcl-2 protein family comprises anti- and proapoptotic members, i.e. they protect the cell from death or favour it.

27 Oct 2020

Study analyzes link between clonal hematopoiesis and treatment-related blood cancer risk

In recent years, improvements in cancer therapy have led to a significant increase in cancer survivorship. Experts estimate that by 2022, the United States will have 18 million cancer survivors, but a subset of those survivors will have long-term health problems to be addressed.

27 Oct 2020

New peptide derivatives that target the SARS-CoV-2 spike protein

In a new study published in the journal Cellular and Molecular Bioengineering, researchers report peptide derivatives, or peptidomimetics, based on the circle residues involved in the interaction of the spike protein and ACE2.

26 Oct 2020

Transcriptomics identifies possible COVID-19 therapies

By using a diverse set of transcriptomic SARS-CoV-2 signatures, US researchers put to use their previously developed drug repositioning pipeline to pinpoint potential drug candidates for the treatment of coronavirus disease (COVID-19). The study is currently available on bioRxiv preprint server.

26 Oct 2020

Small molecules block SARS-CoV-2 spike-ACE2 attachment

The search includes immunological agents, enzyme inhibitors, and soluble competitive inhibitors. Now, a new study published on the preprint server bioRxiv in October 2020 provides preliminary evidence that small molecules can inhibit viral entry by inhibiting spike-ACE2 attachment.

26 Oct 2020

Population-based COVID-19 prevalence surveys in Europe and Americas show risk of bias

A team of researchers from the Federal University of Health Sciences of Porto Alegre and the Federal University of Rio Grande do Sul performed a systematic review to assess these population-based COVID-19 prevalence surveys' reliability and biases qualitatively. Their study is published on the preprint server medRxiv.

26 Oct 2020

New inhibitor of SARS-CoV-2 RNA translation

As the search for effective severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inhibitors continues, a recent study by Yale University School of Medicine researchers published on the preprint server bioRxiv in October 2020 reports the inhibitory effect of the drug merofloxacin on frameshifting during SARS-CoV-2 replication.

26 Oct 2020

Antenatal steroids improve preterm newborn survival in low-resource settings, finds study

The results of a new clinical trial, published today in the New England Journal of Medicine, show that dexamethasone- a glucocorticoid used to treat many conditions, including rheumatic problems and severe COVID-19- can boost survival of premature babies when given to pregnant women at risk of preterm birth in low-resource settings.

23 Oct 2020

Mathematical modeling study offers new insights into optimal timing of antiviral therapies against COVID-19

A new mathematical modeling study by Ashish Goyal and colleagues, informed by data collected from 25 patients hospitalized with COVID-19 in 4 different countries, offers some important new insights into the optimal timing of 4 different antiviral therapies to combat the disease.

23 Oct 2020

Drugs News and Research

Fear and isolation drives PTSD among health/social workers in COVID-19

Genome-wide screens reveal new helpful and harmful COVID-19 related genes

Scientists identify new target for developing novel drugs against several types of cancer

Study analyzes link between clonal hematopoiesis and treatment-related blood cancer risk

New peptide derivatives that target the SARS-CoV-2 spike protein

Transcriptomics identifies possible COVID-19 therapies

Small molecules block SARS-CoV-2 spike-ACE2 attachment

Population-based COVID-19 prevalence surveys in Europe and Americas show risk of bias

New inhibitor of SARS-CoV-2 RNA translation

Antenatal steroids improve preterm newborn survival in low-resource settings, finds study

Mathematical modeling study offers new insights into optimal timing of antiviral therapies against COVID-19

Clinical trial launched to test existing drugs for treatment of a rare blood cancer

Molecular processes in kidney cells may increase diabetics' vulnerability to COVID-19 infection

Potentially inappropriate medication prescribing linked with increased hospitalizations, costs

HU laboratories develop novel treatment methods and technology to fight against COVID-19

Preventive antimalarial treatments drastically reduce malaria infections among school children

Researchers create AI system that matches tumors to best drug combinations

Researchers develop a novel method to test for COVID-19 antibodies

Dexamethasone drug may not benefit COVID-19 patients with diabetes or low albumin levels

Researchers develop a novel way to simplify cellular optogenetic tools

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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