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Plant-based monoclonal antibody increases potency of antibody cocktail against SARS-CoV-2 Omicron variant

A novel mAb against the SARS-CoV-2 RBD through a hybridoma technique, followed by chimerization and expression in plants.

22 Nov 2022

Potent hypervalent nanoparticles against HIV, Lassa and SARS-CoV-2 variants

In a recent study published in the journal Advanced Science, researchers developed molecularly imprinted nanoparticles (nanoMIPs) with broad-spectrum activity against lethal viruses.

21 Nov 2022

Kiwira virus: a new bat-borne hantavirus detected in Africa

Researchers discover a novel hantavirus called the Kiwira virus.

21 Nov 2022

New method for isolating Omicron subvariant and evaluating resistance to therapeutic and vaccine-elicited antibodies

Researchers demonstrated a viral amplification procedure to isolate the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron subvariants.

21 Nov 2022

Evaluating cell-free DNA-based blood tests for early detection of multiple cancers

Researchers assessed several approaches for a circulating cell-free deoxyribonucleic acid (cfDNA)-based multi-cancer early detection (MCED) test. Defining the clinical limit of detection (LOD) based on circulating tumor allele fraction (cTAF) enables the comparison of different approaches.

21 Nov 2022

WHO‒recommended alcohol-based hand rub formulations show efficacy against Monkeypox virus

Researchers demonstrated the efficacy of two World Health Organization (WHO)‒recommended alcohol-based hand rub solutions to inactivate the monkeypox virus (MPXV).

21 Nov 2022

Chitin-immobilized nanobodies for SARS-CoV-2 detection

Researchers demonstrated a novel strategy to detect SARS-CoV-2 using chitin-immobilized nanobodies.

21 Nov 2022

SARS-CoV-2 infection and mRNA vaccination prime transcriptionally distinct CD4+ T cell memory landscapes

Researchers reported that SARS-CoV-2 infection and mRNA vaccination induce distinct memory T cells.

21 Nov 2022

Bispecific antibodies neutralize Sarbecoviruses with increased breadth and potency

In a recent study posted to the bioRxiv* preprint server, researchers developed bispecific antibodies (bsAbs), neutralizing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants.

17 Nov 2022

Comparing post–COVID-19 symptoms two years after SARS-CoV-2 infection

Researchers compared the presence of post–coronavirus disease 2019 (COVID-19) symptoms among hospitalized and non-hospitalized patients in Spain.

17 Nov 2022

Study concludes monkeypox virus is readily detected by qPCR using three clinically validated assays

Researchers validated monkeypox virus (MPXV) quantitative polymerase chain reaction (qPCR) assays.

17 Nov 2022

Researchers identify a conserved site on SARS-CoV-2 spike that a broadly neutralizing macrocyclic peptide can target

Researchers explored the efficiency of a macrocyclic peptide in inhibiting the SARS-CoV-2 spike protein.

17 Nov 2022

SARS-CoV-2 RNA levels, IFN-1, ISGs, and NF-κB gene responses within the respiratory tract of mild and severe COVID-19 patients

Researchers characterized the expression of IFN-1 and IFN-2, ISGs, and NF-κB in the upper respiratory tracts of patients with mild and severe COVID-19, to understand innate immune responses to SARS-CoV-2 infections.

17 Nov 2022

SARS-CoV-2 ‘Deltacron’ variant exhibits immune-escape properties similar to Omicron BA.1

The SARS-CoV-2 Deltacron does not exhibit higher transmissibility or immune evasion than the Omicron BA.1 variant.

16 Nov 2022

SARS-CoV-2 antibodies persist in breast milk following two and three COVID-19 vaccine doses

A new study assesses anti-SARS-CoV-2 antibody levels in breast milk obtained from lactating individuals following two or three COVID-19 vaccine doses.

16 Nov 2022

Development of a potent, broadly protective vaccine against all SARS-CoV-2 variants

In a recent study published in the journal npj Vaccines, researchers in China designed, produced, and evaluated the neutralization efficacy of a recombinant coronavirus disease 2019 (COVID-19) vaccine containing four hot-spot substitution mutations based on a prefusion-stabilized severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein (S) trimer.

15 Nov 2022

Study points to a pathogenic role for compromised anti-SARS-CoV-2 responses in cerebrospinal fluid

Researchers used a high throughput systems serology method to compare serum and CSF samples from SARS-CoV-2 infected individuals with and without long COVID symptoms to determine changes in the SARS-CoV-2 humoral immune responses.

15 Nov 2022

Harnessing the natural potential of venom for drug discovery

Steven Trim, Founder and Cheif Scientific Officer at Venomtech, tells NewsMedical how UK-based Venomtech® harnesses the power of naturally-produced venoms obtained from a collection of nearly 200 species of spiders, scorpions, and centipedes to create compound libraries for drug discovery.

From INTEGRA Biosciences 14 Nov 2022

What was the global SARS-CoV-2 seroprevalence from January 2020 to April 2022?

Researchers assessed SARS-CoV-2 seroprevalence worldwide between January 2020 and April 2022.

14 Nov 2022

Blood samples from healthy individuals have pre-existing anti-SARS-CoV-2 IgGs and IVIg may be an effective therapy for severe COVID-19

A new paper introduces evidence of effective alleviation of disease severity using intravenous immunoglobulin (IVIg).

14 Nov 2022

Assay News and Research

Plant-based monoclonal antibody increases potency of antibody cocktail against SARS-CoV-2 Omicron variant

Potent hypervalent nanoparticles against HIV, Lassa and SARS-CoV-2 variants

Kiwira virus: a new bat-borne hantavirus detected in Africa

New method for isolating Omicron subvariant and evaluating resistance to therapeutic and vaccine-elicited antibodies

Evaluating cell-free DNA-based blood tests for early detection of multiple cancers

WHO‒recommended alcohol-based hand rub formulations show efficacy against Monkeypox virus

Chitin-immobilized nanobodies for SARS-CoV-2 detection

SARS-CoV-2 infection and mRNA vaccination prime transcriptionally distinct CD4+ T cell memory landscapes

Bispecific antibodies neutralize Sarbecoviruses with increased breadth and potency

Comparing post–COVID-19 symptoms two years after SARS-CoV-2 infection

Study concludes monkeypox virus is readily detected by qPCR using three clinically validated assays

Researchers identify a conserved site on SARS-CoV-2 spike that a broadly neutralizing macrocyclic peptide can target

SARS-CoV-2 RNA levels, IFN-1, ISGs, and NF-κB gene responses within the respiratory tract of mild and severe COVID-19 patients

SARS-CoV-2 ‘Deltacron’ variant exhibits immune-escape properties similar to Omicron BA.1

SARS-CoV-2 antibodies persist in breast milk following two and three COVID-19 vaccine doses

Development of a potent, broadly protective vaccine against all SARS-CoV-2 variants

Study points to a pathogenic role for compromised anti-SARS-CoV-2 responses in cerebrospinal fluid

Harnessing the natural potential of venom for drug discovery

What was the global SARS-CoV-2 seroprevalence from January 2020 to April 2022?

Blood samples from healthy individuals have pre-existing anti-SARS-CoV-2 IgGs and IVIg may be an effective therapy for severe COVID-19

Measuring Drug-Target Residence Times with Biochemical Assays eBook

How Omics Technologies Are Transforming Biological Research and Drug Discovery

How microplastics and bacteria interact to drive antibiotic resistance

Single-cell proteomics: Revealing proteome diversity from cellular heterogeneity to non-canonical biology

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