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Excluding children from COVID-19 clinical trials may limit their treatment options

A new viewpoint article from Harvard Medical School, published in the journal JAMA Pediatrics, discusses the hesitancy to include children in coronavirus disease 2019 (COVID-19) clinical trials, potentially diminishing their therapeutic options in the long run.

7 May 2020

Growth hormone plays a key role in increasing survival rates following liver surgery

Growth hormone has been identified as playing a key role in reducing inflammation and increasing survival rates following liver surgery.

5 May 2020

Scientists decode herpes simplex virus 1

Until now, scientists had assumed that there are about 80 so-called open reading frames (ORFs) in the genome of herpes simplex virus 1 (HSV-1).

27 Apr 2020

Bayreuth researchers discover natural protective mechanism against cancer

Susanne Hellmuth and Olaf Stemmann from the Chair of Genetics at the University of Bayreuth have discovered a natural protective mechanism that leads to the programmed death of potentially diseased cells.

23 Apr 2020

A new method to deliver therapeutic proteins inside the body

A new way to deliver therapeutic proteins inside the body uses an acoustically sensitive carrier to encapsulate the proteins and ultrasound to image and guide the package to the exact location required, according to Penn State researchers. Ultrasound then breaks the capsule, allowing the protein to enter the cell.

23 Apr 2020

New study may offer a breakthrough in treating telomere diseases

Capping decades of research, a new study may offer a breakthrough in treating dyskeratosis congenita and other so-called telomere diseases, in which cells age prematurely.

21 Apr 2020

AI may help eliminate use of biopsy for brain cancer patients

Brain cancer patients in the coming years may not need to go under the knife to help doctors determine the best treatment for their tumors.

21 Apr 2020

Greater occurrence of infections correlates with future cancer diagnosis

Patients experienced a greater occurrence of infections in the years preceding a cancer diagnosis.

17 Apr 2020

Experimental drug could stop tumor relapse, mice study shows

A drug that is well-tolerated in patients and prevents cancer coming back in mice has been identified by researchers at the Francis Crick Institute.

14 Apr 2020

Researchers develop a unique radiochemical synthesis approach for treating cancer

Radiolabeled molecules, so-called radiotracers, help nuclear physicians to detect and precisely target tumors, which are often developing due to pathological changes in metabolic processes.

7 Apr 2020

Hereditary genetic defect linked to medulloblastoma destabilizes protein regulation

The causes of 40 percent of all cases of certain medulloblastoma - dangerous brain tumors affecting children - are hereditary.

1 Apr 2020

Understanding hereditary medulloblastomas in children

This is a combined press release between EMBL, the Hopp Children's Cancer Center Heidelberg and the German Cancer Consortium.

1 Apr 2020

Inherited gene mutation can predispose children to SHH medulloblastoma

Investigators at St. Jude Children's Research Hospital, the European Molecular Biology Laboratory, and the German Cancer Research Center have identified ELP1 as a novel predisposition gene in the SHH subgroup of pediatric medulloblastoma.

1 Apr 2020

New type of immunotherapy shows promise for future treatment of ovarian cancer

Malignant ovarian cancer is insidious: Known and feared for vague and uncharacteristic symptoms that often mean the disease is discovered so late that on average only four out of six patients are still alive after five years.

26 Mar 2020

New handheld, high-resolution medical imaging device has potential for bedside scanning

Scientists at Nanyang Technological University, Singapore have developed the prototype of a handheld medical imaging device that can produce images down to resolutions of 1 to 2 micrometers.

25 Mar 2020

YAP signal pathway plays a vital role in the onset of head-and-neck cancer

Joint research between Kobe University and National Hospital Organization Kyushu Cancer Center has revealed that mice with mutations in the YAP signal pathway develop head-and-neck cancer over an extremely short period of time (world's fastest cancer onset mouse model), indicating that this pathway plays a crucial role in the onset of these cancers.

25 Mar 2020

Study provides better understanding of how dangerous cancer metastases arise

In order to colonize other organs and grow into metastases, tumor cells that detach from the parent tumor need to manipulate their new microenvironment and create a 'metastatic niche'.

23 Mar 2020

Immunotherapy treatment shows promise for some patients with advanced rare cancers

A study conducted by researchers at The University of Texas MD Anderson Cancer Center demonstrated acceptable toxicity and anti-tumor activity in patients with four types of advanced, hard-to-treat rare cancers.

20 Mar 2020

Novel MRI contrast agent for early detection of brain metastases

A group of researchers led by Leif Schroeder from the Leibniz-Forschungsinstitut fuer Molekulare Pharmakologie have found a way to detect metastases in certain types of cancer in the brain at an early stage, using only minimal amounts of contrast agent.

19 Mar 2020

Bacteria-trapping protein may contribute to breast cancer metastasis

The protein peptidyl arginine deiminase 4 (PAD4), which enables some immune cells to trap bacteria, promoted breast cancer metastasis in mice when expressed in cancer cells, according to data published in Molecular Cancer Research, a journal of the American Association for Cancer Research.

19 Mar 2020