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New findings could help scientists devise optimal therapies for Friedreich's ataxia

Scripps Research Institute scientists have taken a step closer to understanding the cause of Friedreich's ataxia, a debilitating neurological condition that affects tens of thousands of people worldwide, and so far has no cure.

8 Nov 2010

Scientists identify genes that enable some immune systems to halt HIV; finding could spur drug, vaccine development

Tiny variants in a protein that alerts the body to infection could explain how one in 300 HIV-infected people are able to resist the onset of AIDS for years without needing any treatment, researchers said Thursday in a study published online in the journal Science, Agence France-Presse reports

8 Nov 2010

Affymetrix to contribute genotyping data to 1000 Genomes Project

Affymetrix, Inc. today announced that it will contribute genotyping data for a large set of validated rare and common genomic variants to the 1000 Genomes Project. This powerful data consists of genotyping information from more than 2 million single nucleotide polymorphisms (SNPs), and insertions/deletions (indels), many of which were not previously available from any source.

4 Nov 2010

New Ovation systems improve nucleic acid extraction from FFPE tissue samples

NuGEN Technologies, the provider of innovative RNA and DNA sample preparation solutions for genomic analysis, today announced the availability of the Ovation WGA FFPE System and the Ovation RNA-Seq FFPE System. These are the first commercially available products designed specifically to enable researchers to utilize next-generation sequencing (NGS) technologies to analyze nucleic acids extracted from Formalin-Fixed Paraffin-Embedded (FFPE) tissues.

3 Nov 2010

Inhibitex to present INX-189 data for HCV infections at AASLD Meeting

Inhibitex, Inc. announced today that three posters describing preclinical data on INX-189, the Company's nucleotide polymerase inhibitor in clinical development for the treatment of chronic hepatitis C (HCV) infections, will be presented by various scientists from the Company at the 61st Annual Meeting of the American Association for the Study of Liver Diseases (AASLD) in Boston, MA.

2 Nov 2010

Rubicon's PicoPlex kits provide DNA methylation profiling using next-generation sequencing

Rubicon Genomics today reported data demonstrating that its PicoPlex kits currently marketed for the analysis of single cells for research and diagnostic applications also provide important advantages for genetic and epigenetic profiling using next-generation sequencing (NGS).

2 Nov 2010

454 Life Sciences and DNA Electronics partner to develop high-throughput DNA sequencing system

454 Life Sciences, a Roche Company, announced today that it has entered an exclusive partnership with DNA Electronics for the development of a low-cost, high-throughput DNA sequencing system. As part of the agreement, Roche has signed a non-exclusive license for relevant IP from DNA Electronics' proprietary semiconductor technology portfolio, which enables sensitive detection of nucleotide incorporation during sequencing.

1 Nov 2010

Inhibitex announces initiation of INX-189 Phase 1b clinical trial for HCV infection

Inhibitex, Inc. announced today that it has initiated a Phase 1b, multiple ascending dose (MAD) clinical trial of INX-189, its nucleotide polymerase inhibitor in development for the treatment of chronic infections caused by hepatitis C virus (HCV).

1 Nov 2010

Pharmasset's PSI-938 phase I monotherapy trial shows positive result for HCV treatment

Pharmasset, Inc. reported positive preliminary results today from its phase I monotherapy trial of PSI-352938 for the treatment of chronic hepatitis C (HCV). PSI-938 is a guanosine nucleotide analog polymerase inhibitor in development for the treatment of chronic HCV infection.

28 Oct 2010

1000 Genomes Project publishes comprehensive map of genetic variations in Nature journal

Small genetic differences between individuals help explain why some people have a higher risk than others for developing illnesses such as diabetes or cancer. Today in the journal Nature, the 1000 Genomes Project, an international public-private consortium, published the most comprehensive map of these genetic differences, called variations, estimated to contain approximately 95 percent of the genetic variation of any person on Earth.

28 Oct 2010

New computational techniques to overcome obstacles in hard-to-study genes

Scientists have invented methods to scout the human genome's repetitive landscapes, where DNA sequences are highly identical and heavily duplicated. These advances, as reported today in Science, can identify subtle but important differences among people in the number and content of repeated DNA segments.

28 Oct 2010

Long non-protein coding RNAs respond to SARS virus infection, says study

For the first time, scientists have discovered that a poorly understood class of RNA produced in a mammal's cells during a respiratory virus attack may affect the outcome of the infection. Their findings are reported today in mBio, a journal of the American Society for Microbiology.

27 Oct 2010

Sirius receives U.S. patent for using SNP in Protein C gene

Sirius Genomics, a developer of companion diagnostics, announced today that U.S. Patent 7,820,376 entitled "Protein C Polymorphisms" has been issued by the United States Patent and Trademark Office. The patent relates to a novel use of a Single Nucleotide Polymorphism (SNP) located in the Protein C gene.

27 Oct 2010

SNP array's snapshot of Anopheles gambiae genome can help eliminate malaria

The development and first use of a high-density SNP array for the malaria vector mosquito have established 400,000 genetic markers capable of revealing new insights into how the insect adapts to outsmart insecticides and other preventive measures, according to findings published in the current edition of the journal Science.

26 Oct 2010

Helicos names Illumina and Life Technologies as additional defendants in lawsuit against Pacific Biosciences

Helicos BioSciences Corporation announced today that it has amended its lawsuit against Pacific Biosciences of California, Inc. for patent infringement by naming Illumina, Inc. and Life Technologies Corporation as additional defendants.

From Illumina, Inc. 25 Oct 2010

Researchers find gene mutation mechanism that cause mitochondrial diseases

Scientists have discovered a new cause of spastic ataxia, and believe this cause is also a trigger for other mitochondrial diseases neurological disorders that can lead to serious coordination, growth, visual, speech, and muscle defects.

22 Oct 2010

Genetic variations linked to early menopause: Study

In a new study scientists have found that particular genetic variations are linked to early menopause before the age of 45. They compared the DNA of more than 2,000 women who had experienced early menopause with that of women who had menopause later than 45 years.

19 Oct 2010

Researchers determine genetic blueprint of 13 strains of Lyme disease causing bacteria

Benjamin Luft, M.D., Professor of Medicine, Stony Brook University Medical Center, and a team of medical researchers have determined the genetic blueprint of 13 strains of the bacteria that cause Lyme disease. The finding is crucial to advancing research on Lyme disease, the most frequent tick-borne infection in North America and Europe, and may lead to better diagnostics and a vaccine.

14 Oct 2010

MTN-007 phase trial evaluates vaginal microbicide to prevent rectal transmission of HIV

Tenofovir gel, a vaginal microbicide that has shown promise for preventing HIV through vaginal sex, is being tested in a new trial looking at its safety and acceptability when used rectally. The results of the study, being led by the U.S. National Institutes of Health (NIH)-funded Microbicide Trials Network (MTN), will help determine if the gel should be evaluated further for its potential to prevent HIV among both men and women who engage in receptive anal intercourse.

13 Oct 2010

Akonni receives NIJ grant to develop HCID system for SNP identification

Akonni Biosystems, a molecular diagnostics company that develops, manufactures, and plans to market sophisticated genetic testing devices for diagnosing complex infectious and human diseases, today announced receipt of a nearly $500,000 Phase III Grant from the National Institutes of Justice (NIJ).

13 Oct 2010

Nucleotides News and Research

New findings could help scientists devise optimal therapies for Friedreich's ataxia

Scientists identify genes that enable some immune systems to halt HIV; finding could spur drug, vaccine development

Affymetrix to contribute genotyping data to 1000 Genomes Project

New Ovation systems improve nucleic acid extraction from FFPE tissue samples

Inhibitex to present INX-189 data for HCV infections at AASLD Meeting

Rubicon's PicoPlex kits provide DNA methylation profiling using next-generation sequencing

454 Life Sciences and DNA Electronics partner to develop high-throughput DNA sequencing system

Inhibitex announces initiation of INX-189 Phase 1b clinical trial for HCV infection

Pharmasset's PSI-938 phase I monotherapy trial shows positive result for HCV treatment

1000 Genomes Project publishes comprehensive map of genetic variations in Nature journal

New computational techniques to overcome obstacles in hard-to-study genes

Long non-protein coding RNAs respond to SARS virus infection, says study

Sirius receives U.S. patent for using SNP in Protein C gene

SNP array's snapshot of Anopheles gambiae genome can help eliminate malaria

Helicos names Illumina and Life Technologies as additional defendants in lawsuit against Pacific Biosciences

Researchers find gene mutation mechanism that cause mitochondrial diseases

Genetic variations linked to early menopause: Study

Researchers determine genetic blueprint of 13 strains of Lyme disease causing bacteria

MTN-007 phase trial evaluates vaginal microbicide to prevent rectal transmission of HIV

Akonni receives NIJ grant to develop HCID system for SNP identification

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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