Inflammation News and Research

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UAlberta researchers discover potential new target for treatment of multiple sclerosis

In the relentless battle against multiple sclerosis (MS), U of A researchers recently discovered an entirely new cellular mechanism--an underlying defect in brain cells--that may to be blame for the disease, and a potential hallmark that may be a target for future treatment.

23 Mar 2017

Study links gastrointestinal disturbances of GWI with changes in intestinal microbiota

A new study from the University of South Carolina has found a gastrointestinal link that could help explain many of the health issues facing those with Gulf War Illness (GWI) as well as opening new pathways to treatment options that may improve both gastrointestinal and neurological symptoms associated with the disorder.

23 Mar 2017

Statin drugs may offer treatment option for chronic liver disease

Statin drugs are widely used to manage high cholesterol and reduce the risk of cardiovascular disease. But in a new review of more than 50 studies, researchers cite reductions in liver inflammation and improvements in other related factors as reasons why statins make good candidates for treating chronic liver disease.

23 Mar 2017

Analysis of antibodies could be new tool for predicting prognosis and choosing therapy for RA patients

In rheumatoid arthritis, antibodies are formed that affect the inflammation in the joints. In an article published today in the journal Annals of the Rheumatic Diseases, researchers at Uppsala University show that antibodies against the cartilage protein collagen II are associated with a good prognosis.

23 Mar 2017

Scientists develop new bone grafting material from sea urchin spines

More than 2 million procedures every year take place around the world to heal bone fractures and defects from trauma or disease, making bone the second most commonly transplanted tissue after blood.

23 Mar 2017

New study challenges description of airway inflammation in smokers and COPD patients

A new study challenges the widely accepted but oversimplified description of airway inflammation in smokers and patients with chronic obstructive pulmonary disease (COPD).

22 Mar 2017

New review addresses mysteries behind ‘good’ HDL cholesterol metabolism

A new review addresses the mysteries behind "good" HDL cholesterol and why boosting its levels does not necessarily provide protection from cardiovascular risk for patients. It appears that augmenting the function of HDL cholesterol, rather than its concentration, is key.

22 Mar 2017

Study shows efficacy of biologics for mucosal healing in Crohn's disease and ulcerative colitis

Although anti-inflammatory treatments are quite effective at reducing symptoms in patients with Crohn's disease and ulcerative colitis, the mucosal lining of the intestine often remains ulcerated, and many patients still ultimately require surgery.

22 Mar 2017

Changes in the vascular system could play role in initiating Alzheimer’s disease

As the average age of Americans increases, so too does the problem of Alzheimer's, one of the world's most common neurological diseases. In recent years, scientists have explored many new approaches to clear the plaques and tangles in the brain that characterize the condition, but the new drugs have largely turned out to be disappointing.

22 Mar 2017

Tsimane indigenous South Americans have lowest prevalence of coronary atherosclerosis of any population yet studied

The Tsimane people – a forager-horticulturalist population of the Bolivian Amazon – have the lowest reported levels of vascular ageing for any population, with coronary atherosclerosis (hardening of the arteries) being five times less common than in the US, according to a study published in The Lancet and being presented at the American College of Cardiology conference.

21 Mar 2017

Scientists identify molecules that may be key to drug resistance in estrogen-driven breast cancers

Three-quarters of all breast cancer tumors are driven by the hormone estrogen. These tumors are frequently treated with drugs to suppress estrogen receptor activity, but unfortunately, at least half of patients do not respond to these treatments, leaving them with drug-resistant tumors and few options.

20 Mar 2017

Early treatment with stem cells can safely help recovery in stroke patients, study shows

A multicenter trial looking at whether a single dose of millions of adult, bone-marrow-derived stem cells can aid stroke recovery indicates it's safe and well-tolerated by patients but may not significantly improve their recovery within the first three months, researchers report.

20 Mar 2017

New markers linked to recurrence of erratic heartbeats in some patients after ablation therapy

Ablation procedures restore a regular heartbeat in patients who have a dangerous, abnormal heart rhythm called atrial fibrillation. But it doesn't always work. Now, a new study suggests that certain molecules are associated with the recurrence of erratic heartbeats in some patients after ablation therapy.

20 Mar 2017

Researchers highlight how biomarkers after ACL reconstruction may signal severity of PTOA later in life

A majority of Anterior Cruciate Ligament (ACL) reconstruction patients develop a condition known as posttraumatic osteoarthritis (PTOA) within 15 years of surgery, which can be debilitating and limit activity. Researchers presenting their work at the American Orthopaedic Society for Sports Medicine's Specialty Day in San Diego are highlighting how a set of biomarkers on the day of surgery may explain why some individuals have worse PTOA than others after two years.

20 Mar 2017

Linking RNA to autoimmune diseases

An interview with Dr. Chase Spurlock, CEO, discussing IQuity's research into IncRNAs and how they are linked to autoimmue diseases.

20 Mar 2017

Blood test can identify patients with heart injury after non-cardiac surgery

A blood test for a protein called high-sensitivity troponin T, which is released into the bloodstream when injury to the heart occurs, can identify patients with heart damage after non-cardiac surgery whose lives could potentially be saved with timely treatment, according to research presented at the American College of Cardiology's 66th Annual Scientific Session.

20 Mar 2017

Novel synthetic HDL-C injection shows no benefit on arterial plaques

Injection of a novel form of synthetic high-density lipoprotein cholesterol (HDL-C), or good cholesterol, into the arteries of patients who had recently had a heart attack did not reduce the volume of fatty deposits, or plaque, in the arteries, compared with placebo injections, according to research presented at the American College of Cardiology's 66th Annual Scientific Session.

20 Mar 2017

Clinical study to examine whether antibiotics can be safe, effective alternative to appendectomy

For 130 years, surgery has been the standard treatment for appendicitis — inflammation of the appendix, a short tube extending from the colon.

17 Mar 2017

High levels of two biomarkers can predict risk for adverse cardiac events, research suggests

New research suggests that GlycA, a newly identified blood marker, and C-reactive protein both independently predict major adverse cardiac events, including heart failure and death. Patients who have high levels of both biomarkers are at especially high risk.

17 Mar 2017

Better understanding of pre-metastatic niches could lead to new preventive therapies

Metastasis is the major cause of cancer-related death and its appearance remains a phenomenon that is difficult to predict and manage.

17 Mar 2017

Inflammation News and Research

UAlberta researchers discover potential new target for treatment of multiple sclerosis

Study links gastrointestinal disturbances of GWI with changes in intestinal microbiota

Statin drugs may offer treatment option for chronic liver disease

Analysis of antibodies could be new tool for predicting prognosis and choosing therapy for RA patients

Scientists develop new bone grafting material from sea urchin spines

New study challenges description of airway inflammation in smokers and COPD patients

New review addresses mysteries behind ‘good’ HDL cholesterol metabolism

Study shows efficacy of biologics for mucosal healing in Crohn's disease and ulcerative colitis

Changes in the vascular system could play role in initiating Alzheimer’s disease

Tsimane indigenous South Americans have lowest prevalence of coronary atherosclerosis of any population yet studied

Scientists identify molecules that may be key to drug resistance in estrogen-driven breast cancers

Early treatment with stem cells can safely help recovery in stroke patients, study shows

New markers linked to recurrence of erratic heartbeats in some patients after ablation therapy

Researchers highlight how biomarkers after ACL reconstruction may signal severity of PTOA later in life

Linking RNA to autoimmune diseases

Blood test can identify patients with heart injury after non-cardiac surgery

Novel synthetic HDL-C injection shows no benefit on arterial plaques

Clinical study to examine whether antibiotics can be safe, effective alternative to appendectomy

High levels of two biomarkers can predict risk for adverse cardiac events, research suggests

Better understanding of pre-metastatic niches could lead to new preventive therapies

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Bringing real-time analytics to downstream bioprocess monitoring

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Evaluating new approaches for rare disease genomics

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