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DSMB recommends discontinuation of Aeterna Zentaris’ perifosine Phase 3 study for MM

Aeterna Zentaris Inc. today announced that an independent Data Safety Monitoring Board has recommended discontinuing the ongoing Phase 3 study comparing the efficacy and safety of perifosine to placebo when combined with bortezomib (Velcade) and dexamethasone in patients with relapsed or relapsed/refractory multiple myeloma.

12 Mar 2013

MiR-198 controls migration of skin cells necessary for wounds to close and heal

Patients with diseases such as diabetes suffer from painful wounds that take a long time to heal making them more susceptible to infections that could even lead to amputations. A*STAR's discovery paves the way for therapeutics to improve healing of such chronic wounds, which are a significant burden to patients.

11 Mar 2013

Weill Cornell receives NIMH grant to discover novel biomarkers for chronic fatigue syndrome

Weill Cornell Medical College has been awarded more than $1.9 million by the National Institute of Mental Health of the National Institutes of Health to lead an innovative research study using advanced neuroimaging and clinical evaluations of patients with chronic fatigue syndrome (CFS).

8 Mar 2013

Family-focused therapy improves mood symptoms in youth at risk of bipolar disorder

A study published in the February 2013 issue of the Journal of the American Academy of Child and Adolescent Psychiatry found that children and adolescents with major depression or subthreshold forms of bipolar disorder - and who had at least one first-degree relative with bipolar disorder - responded better to a 12-session family-focused treatment than to a briefer educational treatment.

8 Mar 2013

TV ads may drive over-diagnosis of high cholesterol and over-treatment with statins

Television advertising may drive over-diagnosis of high cholesterol and over-treatment with statins, according to a new study¹ by Dr. Jeff Niederdeppe from Cornell University in the US and colleagues. It appears that a trip to the doctor enquiring about statins advertised on TV often leads to a prescription.

8 Mar 2013

Nearly 90% of young children continue to struggle with ADHD symptoms despite treatment

A study published in the March 2013 issue of the Journal of the American Academy of Child and Adolescent Psychiatry found that 9 out of 10 young children with moderate to severe attention-deficit/hyperactivity disorder (ADHD) continue to experience serious to severe symptoms and impairment long after their original diagnoses, and in many cases, despite treatment.

8 Mar 2013

Southeast Asia's commercial trade plays a central role in spread of amphibian pathogens

A team of scientists led by the Wildlife Conservation Society (WCS) and the National University of Singapore (NUS), revealed in a new study, for the first time, the presence of the pathogenic chytrid fungus (Batrachochytrium dendrobatidis) in amphibians sampled in Singapore. And the American bullfrog may be a central player in the spread of the disease.

8 Mar 2013

Technique breathes new life into gastric cancer diagnosis

A nanomaterial breath test can accurately distinguish gastric cancer from benign stomach disorders, preliminary results show.

7 Mar 2013

Lower back pain and spinal cancer: an interview with Dr Nicholas Henschke, University of Heidelberg

While lower back pain is a common condition around the world, in only a very small proportion of people – less than 5% - will this be caused by a serious problem such as fracture, infection, or tumour.

7 Mar 2013

Study evaluates patients with regional myocardial wall thinning

Among patients with coronary artery disease referred for cardiovascular magnetic resonance and found to have regional myocardial wall thinning (of the heart muscle), limited scar burden was associated with improved contraction of the heart and reversal of wall thinning after revascularization, suggesting that myocardial thinning is potentially reversible, according to a study appearing in the March 6 issue of JAMA.

7 Mar 2013

Technology aids, such as electronic alerts, may help prevent missed diagnoses

But the authors of the analysis of past studies on electronic-based patient safety efforts say few of those studies have tracked direct improvements to patient health, Reuters reports.

7 Mar 2013

Study investigates how cancer cells 'hijack' platelets

A new research study has investigated how cancer cells 'hijack' blood cells known as platelets, enabling cancer to spread around the body and promoting the growth of new tumours, it was reported today at the annual Royal College of Surgeons in Ireland (RCSI) Research Day.

7 Mar 2013

Study shows how nanoparticles can be formed to efficiently carry cancer drugs to tumor cells

Small particles loaded with medicine could be a future weapon for cancer treatment. A recently-published study shows how nanoparticles can be formed to efficiently carry cancer drugs to tumor cells. And because the particles can be seen in MRI images, they are traceable.

7 Mar 2013

Researchers discover likely origin of epithelial ovarian cancer

Cornell University researchers have discovered a likely origin of epithelial ovarian cancer (ovarian carcinoma), the fifth leading cause of cancer death among women in the United States.

7 Mar 2013

Metamaterial would enable ultrasound to produce high-quality images

Ultrasound technology could soon experience a significant upgrade that would enable it to produce high-quality, high-resolution images, thanks to the development of a new key material by a team of researchers that includes a professor in the Department of Biomedical Engineering at Texas A&M University.

6 Mar 2013

Two novel radiolabeled small molecules can help detect prostate cancer

Two novel radiolabeled small molecules targeting prostate-specific membrane antigen (PSMA) have excellent potential for further development as diagnostic and therapeutic radiopharmaceuticals, according to research published this month in The Journal of Nuclear Medicine.

6 Mar 2013

Misdiagnosed bipolar depression has subtle clinical features

Increased appetite, sleep, and weight gain, among other clinical features, can be used to help identify patients with bipolar disorder who have been misdiagnosed with major depressive disorder.

5 Mar 2013

Study reveals key predictors of speech gains in children with autism, severe language delay

New findings published in Pediatrics (Epub ahead of print) by the Kennedy Krieger Institute's Center for Autism and Related Disorders reveal that 70 percent of children with autism spectrum disorders who have a history of severe language delay, achieved phrase or fluent speech by age eight.

5 Mar 2013

tRNA synthetases play unexpected and critical role in cancer metastasis

Studied for decades for their essential role in making proteins within cells, several amino acids known as tRNA synthetases were recently found to have an unexpected - and critical - additional role in cancer metastasis in a study conducted collaboratively in the labs of Karen Lounsbury, Ph.D., University of Vermont professor of pharmacology, and Christopher Francklyn, Ph.D., UVM professor of biochemistry.

5 Mar 2013

Microcystins in drinking water

An interview with Rohan Thakur, discussing the prevalence of microcystins in drinking water, and the use of LC-MS to identify cyanotoxins within water samples.

From Bruker Daltonics 5 Mar 2013

Diagnostic News and Research

DSMB recommends discontinuation of Aeterna Zentaris’ perifosine Phase 3 study for MM

MiR-198 controls migration of skin cells necessary for wounds to close and heal

Weill Cornell receives NIMH grant to discover novel biomarkers for chronic fatigue syndrome

Family-focused therapy improves mood symptoms in youth at risk of bipolar disorder

TV ads may drive over-diagnosis of high cholesterol and over-treatment with statins

Nearly 90% of young children continue to struggle with ADHD symptoms despite treatment

Southeast Asia's commercial trade plays a central role in spread of amphibian pathogens

Technique breathes new life into gastric cancer diagnosis

Lower back pain and spinal cancer: an interview with Dr Nicholas Henschke, University of Heidelberg

Study evaluates patients with regional myocardial wall thinning

Technology aids, such as electronic alerts, may help prevent missed diagnoses

Study investigates how cancer cells 'hijack' platelets

Study shows how nanoparticles can be formed to efficiently carry cancer drugs to tumor cells

Researchers discover likely origin of epithelial ovarian cancer

Metamaterial would enable ultrasound to produce high-quality images

Two novel radiolabeled small molecules can help detect prostate cancer

Misdiagnosed bipolar depression has subtle clinical features

Study reveals key predictors of speech gains in children with autism, severe language delay

tRNA synthetases play unexpected and critical role in cancer metastasis

Microcystins in drinking water

Industry Focus eBook - Cell biology (5th edition) eBook

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

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