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Genomic analysis of Ashaninka individuals reveals an unexpected amount of underlying diversity

The Ashaninka are the most numerous Indigenous people living in the rainforests of Peru and Brazil where they inhabit a crucial area between the Andes and sources of the Amazon River. And yet, despite the size of the population and their importance in the past and present, their genetic history has remained understudied.

17 Mar 2023

Computational analysis of large genetic datasets reveals rare disease etiologies

Using a new computational approach they developed to analyze large genetic datasets from rare disease cohorts, researchers at the Icahn School of Medicine at Mount Sinai and colleagues have discovered previously unknown genetic causes of three rare conditions: primary lymphedema (characterized by tissue swelling), thoracic aortic aneurysm disease, and congenital deafness.

17 Mar 2023

Loss of a beta cell subset might contribute to type 2 diabetes

Multiple types of beta cells produce insulin in the pancreas, helping to balance blood sugar levels. Losing a particularly productive type of beta cell may contribute to the development of diabetes, according to a new study by Weill Cornell Medicine investigators.

17 Mar 2023

When mass spectrometry redefines molecular biology and biochemistry – the future of spatial omics

In this interview, Bruker speaks with Ramon Sun on the topic of SpatialOMx - a field that is currently experiencing great changes. Dive in to discover how Bruker will rise to the challenge.

From Bruker Daltonics 17 Mar 2023

Does vitamin D play an anti-viral role against SARS-CoV-2?

Researchers screened various compounds for anti-viral properties against SARS-CoV-2.

17 Mar 2023

Anti-Omicron antibodies are induced by hypermutation with ancestral BNT162b2 COVID vaccine

Scientists from the Republic of Korea have analyzed B-cell receptor repertoires induced by an mRNA-based coronavirus disease 2019 (COVID-19) vaccine and found that somatic hypermutations in B-cell receptor heavy chain are responsible for broadening its specificity for unexposed antigens.

16 Mar 2023

Monoclonal antibody-based blocking ELISA for SARS-CoV-2 detection in animals

In a recent study posted to the bioRxiv* preprint server, researchers in the United States described a blocking enzyme-linked immunosorbent assay (ELISA) to identify severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exposure in animals.

16 Mar 2023

Study implicates gut microbiome and immune response in hospital-acquired infections

In a recent study published in the journal Nature Medicine, researchers at the University of Calgary analyzed the dynamics of fecal microbiota and conducted single-cell profiling of inflammatory responses and systemic immunity to determine associations between gut microbiome dysbiosis and an increased risk of nosocomial infections.

16 Mar 2023

Ipsilateral vaccination improves response to second dose of COVID-19 vaccine

Researchers examine whether the involvement of the ipsilateral or contralateral lymph nodes affected the immune response during sequential vaccination.

16 Mar 2023

Research highlights the importance of ventilation and air filtration to reduce pathogen transmission

Testing of ambient air can be used to monitor the community circulation of respiratory pathogens.

16 Mar 2023

Trial shows encouraging results for neoadjuvant dual immunotherapy and chemotherapy in patients with resectable NSCLC

In a Phase II trial led by researchers from The University of Texas MD Anderson Cancer Center, adding ipilimumab to a neoadjuvant, or pre-surgical, combination of nivolumab plus platinum-based chemotherapy, resulted in a major pathologic response (MPR) in half of all treated patients with early-stage, resectable non-small cell lung cancer (NSCLC).

16 Mar 2023

Detecting tissue-resident memory T cells in solid tumors

In this interview, NewsMedical talks with Cerba Research about in situ multiplex analysis of regulatory and effector T cells in tumors.

16 Mar 2023

Creating more effective and safe treatments for COVID-19

When approaching a task, members of a team need to work in synergy. Nothing can be accomplished if you're pulling in different directions.

16 Mar 2023

Study highlights a persistent life expectancy gap among patients living with sickle cell disease

While research has long established disparities in health outcomes among individuals living with sickle cell disease (SCD), few studies have quantified these gaps.

16 Mar 2023

Scientists develop genetically defined mouse models for multiple myeloma subtypes

A team of scientists led by Martin Janz and Klaus Rajewsky at the Max Delbrück Center has successfully generated genetically defined mouse models for two subtypes of multiple myeloma.

16 Mar 2023

One-Pot-LAMP: A promising tool for non-small cell lung cancer diagnosis

Researchers assessed the efficiency of a genetic decoding system for diagnosing non-small cell lung cancer (NSCLC).

16 Mar 2023

Structure of cellular shredders varies according to cell type, study shows

"Miniature shredders" are at work in each cell, disassembling and recycling cell components that are defective or no longer required.

16 Mar 2023

A high-throughput CAMP assay for the evaluation of the vitamin D-dependent antimicrobial response

A recent developed a novel and high-throughput assay to evaluate cathelicidin antimicrobial peptide.

16 Mar 2023

Albumedix and Heartseed announce Recombumin® as a critical excipient in the manufacture of Heartseed's HS-001 investigational cell therapy as its first in-human trial commences

Albumedix Ltd, Nottingham, United Kingdom, now part of the global life science group Sartorius, and Heartseed Inc ('Heartseed'), Tokyo, Japan, Tuesday 14th March 2023, announce that Recombumin® is a critical component of Heartseed's HS-001, an investigational cardiac remuscularization cell therapy which has commenced first in human dosing.

From Albumedix Ltd. 16 Mar 2023

Forecasting adverse effects and prognosis in TB patients using AI

A recent study applied AI to forecast the prognosis and adverse effects of TB.

16 Mar 2023

Cell News and Research

Genomic analysis of Ashaninka individuals reveals an unexpected amount of underlying diversity

Computational analysis of large genetic datasets reveals rare disease etiologies

Loss of a beta cell subset might contribute to type 2 diabetes

When mass spectrometry redefines molecular biology and biochemistry – the future of spatial omics

Does vitamin D play an anti-viral role against SARS-CoV-2?

Anti-Omicron antibodies are induced by hypermutation with ancestral BNT162b2 COVID vaccine

Monoclonal antibody-based blocking ELISA for SARS-CoV-2 detection in animals

Study implicates gut microbiome and immune response in hospital-acquired infections

Ipsilateral vaccination improves response to second dose of COVID-19 vaccine

Research highlights the importance of ventilation and air filtration to reduce pathogen transmission

Trial shows encouraging results for neoadjuvant dual immunotherapy and chemotherapy in patients with resectable NSCLC

Detecting tissue-resident memory T cells in solid tumors

Creating more effective and safe treatments for COVID-19

Study highlights a persistent life expectancy gap among patients living with sickle cell disease

Scientists develop genetically defined mouse models for multiple myeloma subtypes

One-Pot-LAMP: A promising tool for non-small cell lung cancer diagnosis

Structure of cellular shredders varies according to cell type, study shows

A high-throughput CAMP assay for the evaluation of the vitamin D-dependent antimicrobial response

Albumedix and Heartseed announce Recombumin® as a critical excipient in the manufacture of Heartseed's HS-001 investigational cell therapy as its first in-human trial commences

Forecasting adverse effects and prognosis in TB patients using AI

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