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Scientists devised technique to make antibody-drug conjugates, basis of new therapies

Chemists at The Scripps Research Institute (TSRI) have devised a new technique for connecting drug molecules to antibodies to make advanced therapies.

8 Oct 2013

Anti-inflammatory mechanism leads to development of oral medications for atherosclerosis, IBS

Research led by Charles Nichols, PhD, Associate Professor of Pharmacology at LSU Health Sciences Center New Orleans, describes a powerful new anti-inflammatory mechanism that could lead to the development of new oral medications for atherosclerosis and inflammatory bowel disorders (IBS).

7 Oct 2013

Glutamergic agents may be used as novel treatment for mood and anxiety disorders

Glutamergic agents may one day be used as a novel treatment for mood and anxiety disorders, new research presented at the 26th ECNP Congress suggests.

7 Oct 2013

New therapeutic targets and drugs may benefit people with leukemia

An Indiana University cancer researcher and his colleagues have discovered new therapeutic targets and drugs that may someday benefit people with certain types of leukemia or blood cancer.

5 Oct 2013

Study: Physical activity reduces risk of breast cancer in postmenopausal women

A large new American Cancer Society study adds to increasing evidence that physical activity reduces the risk of breast cancer in postmenopausal women. Researchers say moderate recreational activity was associated with a 14 percent lower risk and high physical activity with a 25 percent lower risk of breast cancer compared to women who were active at the lowest level.

4 Oct 2013

Walking an hour per day associated with lower risk of breast cancer in women

Postmenopausal women who were very active or walked for at least seven hours a week had a reduced risk for breast cancer, according to a study published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research.

4 Oct 2013

New picture of interaction between nervous & immune systems could lead to novel therapies

A new picture of how the nervous system interacts with the immune system to cause the itch and inflammation associated with eczema, a chronic skin disease, could lead to new therapies for the condition, according to University of California, Berkeley, scientists.

4 Oct 2013

New method to monitor activity of gene promoters during response to drug

When developing new drugs, monitoring cellular responses to candidate compounds is essential for assessing their efficacy and safety. Researchers from the RIKEN Center for Life Science Technologies report a new method to monitor and quantify the activity of gene promoters during the response to a drug, using the advanced gene expression analysis method CAGE followed by single-molecule sequencing.

3 Oct 2013

Hypertension Drug May Aid Cancer Treatment

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2 Oct 2013

Mutant protein blocks HIV infection and transmission, scientists find

A mutant of an immune cell protein called ADAP (adhesion and degranulation-promoting adaptor protein) is able to block infection by HIV-1 (human immunodeficiency virus 1), new University of Cambridge research reveals. The researchers, who were funded by the Wellcome Trust, believe that their discovery will lead to new ways of combatting HIV.

2 Oct 2013

Women of Mexican descent more likely to be diagnosed with aggressive form of breast cancer

Scientific data suggest that a woman reduces her risk of breast cancer by breastfeeding, having multiple children and giving birth at a younger age. A study led by the University of California, San Diego School of Medicine and recently published online by Cancer Epidemiology, Biomarkers & Prevention, indicates that women of Mexican descent may not fit that profile. In fact, results suggest that women of Mexican descent with more children and those who breastfeed are more likely to be diagnosed with an aggressive form of breast cancer.

2 Oct 2013

Breast cancer incidence rates increasing among African Americans; reasons unclear

Breast cancer incidence rates increased slightly among African American women from 2006 to 2010, bringing those rates closer to the historically higher rates among white women, according to a new analysis by American Cancer Society researchers. The explanation behind the rise is unclear.

1 Oct 2013

Research reveals significant role of Axl receptor in progression, therapeutic resistance of AML

BerGenBio AS, an oncology biopharmaceutical company, announces that a paper entitled "Axl, a prognostic and therapeutic target in acute myeloid leukemia mediates paracrine cross-talk of leukemia cells with bone marrow stroma" by Ben-Batalla et al., has been published in Blood, the most cited peer-reviewed research journal in the field of hematology.

1 Oct 2013

MD Anderson-developed aerosol triggers innate immunity to squelch infections

Research on an aerosol that jump-starts a rapid immune response to stifle viral respiratory infections before they can provoke asthma attacks has earned major funding from the National Institutes of Health.

1 Oct 2013

Intercalated erlotinib/chemotherapy shows mixed results in NSCLC

A study comparing erlotinib alone with erlotinib intercalated with chemotherapy has failed to demonstrate a clear advantage of the combination strategy when used to treat relapsed patients with non-small-cell lung cancer, Dutch researchers report.

30 Sep 2013

Study reveals new findings on role of psychotherapy in regulating serotonin receptors

A paper published in the current issue of Psychotherapy and Psychosomatics provides new findings on the role of psychotherapy in regulating serotonin receptors.

30 Sep 2013

Study indicates that RNA translation is dictated by translational hotspots

Protein synthesis in the extensions of nerve cells, called dendrites, underlies long-term memory formation in the brain, among other functions. "Thousands of messenger RNAs reside in dendrites, yet the dynamics of how multiple dendrite messenger RNAs translate into their final proteins remain elusive," says James Eberwine, PhD, professor of Pharmacology, Perelman School of Medicine at the University of Pennsylvania, and co-director of the Penn Genome Frontiers Institute.

27 Sep 2013

Mayo Clinic experts to discuss risk factors, screening and treatments for breast cancer

October is National Breast Cancer Awareness Month, and Mayo Clinic breast cancer experts are available to discuss risk factors, screening and treatments.

27 Sep 2013

Study: Antidepressant drugs prove to be effective against SCLC patients

A bioinformatics approach to repurposing drugs resulted in identification of a class of antidepressants as a potential new treatment for small-cell lung cancer (SCLC), according to a study published in Cancer Discovery, a journal of the American Association for Cancer Research.

27 Sep 2013

Icotinib matches gefitinib in NSCLC second or third line

Icotinib has been found to be noninferior to gefitinib in patients with non-small-cell lung cancer, according to reports from the phase III Chinese double-blind ICOGEN study.

26 Sep 2013

Receptor News and Research

Scientists devised technique to make antibody-drug conjugates, basis of new therapies

Anti-inflammatory mechanism leads to development of oral medications for atherosclerosis, IBS

Glutamergic agents may be used as novel treatment for mood and anxiety disorders

New therapeutic targets and drugs may benefit people with leukemia

Study: Physical activity reduces risk of breast cancer in postmenopausal women

Walking an hour per day associated with lower risk of breast cancer in women

New picture of interaction between nervous & immune systems could lead to novel therapies

New method to monitor activity of gene promoters during response to drug

Hypertension Drug May Aid Cancer Treatment

Mutant protein blocks HIV infection and transmission, scientists find

Women of Mexican descent more likely to be diagnosed with aggressive form of breast cancer

Breast cancer incidence rates increasing among African Americans; reasons unclear

Research reveals significant role of Axl receptor in progression, therapeutic resistance of AML

MD Anderson-developed aerosol triggers innate immunity to squelch infections

Intercalated erlotinib/chemotherapy shows mixed results in NSCLC

Study reveals new findings on role of psychotherapy in regulating serotonin receptors

Study indicates that RNA translation is dictated by translational hotspots

Mayo Clinic experts to discuss risk factors, screening and treatments for breast cancer

Study: Antidepressant drugs prove to be effective against SCLC patients

Icotinib matches gefitinib in NSCLC second or third line

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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