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New comprehensive edition for neurologists provides invaluable source of reference

A new comprehensive edition of a standard work, detailing and illustrating the organization, structure, function and connectivity of all individual brainstem nuclei. For neuroscientists and neurologists this atlas provides an invaluable and complete source of reference for both their scientific research and everyday clinical practice.

17 Dec 2013

U-M researchers report novel approach for treating tinnitus in humans

For tens of millions of Americans, there's no such thing as the sound of silence. Instead, even in a quiet room, they hear a constant ringing, buzzing, hissing, humming or other noise in their ears that isn't real. Called tinnitus, it can be debilitating and life-altering.

17 Dec 2013

Researchers discover completely new targets for treatment of blood cancers

A particularly aggressive form of leukemia is the acute lymphoblastic leukemia (ALL). It is especially common among children and very difficult to treat. Researchers from the University of Veterinary Medicine, Vienna have now discovered completely new targets for the treatment of blood cancers.

13 Dec 2013

Increased levels of protein HSET linked with worse breast cancer outcomes in African-Americans

Among African-American women with breast cancer, increased levels of the protein HSET were associated with worse breast cancer outcomes, according to results presented here at the Sixth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved, held Dec. 6-9.

9 Dec 2013

PKM2 protein controls mitosis, saving cancer cells from death and promoting brain tumor growth

Researchers have caught a protein they previously implicated in a variety of cancer-promoting roles performing a vital function in cell division, survival and development of brain tumors.

8 Dec 2013

Understanding biochemical mechanisms associated with memory formation

A discovery by a research team led by Dr. Ryohei Yasuda at the Max Planck Florida Institute for Neuroscience has significantly advanced basic understanding of biochemical mechanisms associated with how memories are formed.

6 Dec 2013

Researchers produce erythrocyte progenitor cells by transducing two genes into iPS and ES cells

By transducing two genes (c-MYC and BCL-XL) into iPS cells and ES cells, a Kyoto University research team led by Prof. Koji Eto at CiRA has succeeded in producing erythrocyte progenitor cells with almost unlimited ability to replicate in vitro, which they then differentiated successfully into mature erythrocytes. Although these erythrocytes consisted mostly of fetal-type hemoglobin, they were confirmed to have oxygen-carrying capacity and to have circulatory capacity following transfusion into mice.

6 Dec 2013

Neurosurgery in Parkinson's disease: Social adjustment, quality of life and coping strategies

Subthalamic nucleus deep brain stimulation can significantly improve the motor features of the Parkinson's disease in carefully selected patients. However, effects of subthalamic nucleus deep brain stimulation on the social adjustment, coping strategies and mental health-related quality of life of these patients remain unclear.

5 Dec 2013

Scientists design small synthetic molecules capable of blocking AIDS virus replication

A multidisciplinary team of scientists from Spanish universities and research centres, among which is the University of Valencia, has managed to design small synthetic molecules capable of joining to the genetic material of the AIDS virus and blocking its replication.

28 Nov 2013

DFG approves establishment of new Collaborative Research Centres

The Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) has approved the establishment of nine new Collaborative Research Centres (CRCs).

27 Nov 2013

CSHL identifies specific stretch of DNA that helps cancerous blood cells to proliferate in AML

A team of researchers at Cold Spring Harbor Laboratory (CSHL) has identified a leukemia-specific stretch of DNA called an enhancer element that enables cancerous blood cells to proliferate in Acute Myeloid Leukemia (AML), a devastating cancer that is incurable in 70% of patients.

27 Nov 2013

UK researchers identify a gene that regulates alcohol consumption

UK researchers have discovered a gene that regulates alcohol consumption and when faulty can cause excessive drinking. They have also identified the mechanism underlying this phenomenon.

26 Nov 2013

Neuroscientists discover new role played by common but mysterious class of brain cells

Stanford University School of Medicine neuroscientists have discovered a new role played by a common but mysterious class of brain cells.

26 Nov 2013

Research: Notch protein plays essential role in triggering T-cell development

The lab of Avinash Bhandoola, PhD, professor of Pathology and Laboratory Medicine, has studied the origins of T cells for many years. One protein called Notch, which has well-known roles in the development of multiple tissues, plays an essential role in triggering T-cell development.

25 Nov 2013

Researchers identify immune cell protein that sets off body's initial response against viral infection

A Massachusetts General Hospital-led research team has identified an immune cell protein that is critical to setting off the body's initial response against viral infection. The report that will be published in an upcoming issue of Nature Immunology and is receiving early online release describes finding that a protein called GEF-H1 is essential to the ability of macrophages - major contributors to the innate immune system - to respond to viral infections like influenza.

25 Nov 2013

Multiple sclerosis researchers receive NMSS drug development grant

A $500,000 drug development grant from the National Multiple Sclerosis Society was awarded to a partnership between a multiple sclerosis research team at the Icahn School of Medicine at Mount Sinai and Karyopharm Therapeutics Inc., a clinical stage pharmaceutical company. Dr. Patrizia Casaccia, MD, PhD, Professor in the Departments of Neuroscience and Genetics and Genomics, at Icahn School of Medicine at Mount Sinai, will be the academic lead.

21 Nov 2013

Researchers discover new human enzyme that facilitates DNA repair during DNA copying process

Every day, the human body produces new cells to regenerate tissues and repair those that have suffered injury. Each time this happens, the cells make copies of their DNA that they will pass on to the resulting daughter cells. This process of copying the DNA, also called replication, is very delicate, given that it can generate severe alterations in the DNA that are associated with malignant transformation or ageing.

21 Nov 2013

Study confirms therapeutic potential of inhibiting Aurora-A in cancer treatment

Aurora-A is a protein involved in the cell division process that is highly expressed or synthesised in a large number of human cancers, especially in those associated with a bad prognosis. Several pharmaceutical companies have recently developed these protein inhibitors, although the therapeutic and physiological effects that blocking Aurora-A might have on adult tissues are still unknown.

19 Nov 2013

Scientists reveal surprising role for HDAC1 proteins in development of skin tumors

Findings by scientists from the Max F. Perutz Laboratories (MFPL) of the University of Vienna and the Medical University of Vienna reveal a surprising role for histone deacetylase 1 (HDAC1) - a member of a family of chromatin modifying proteins - in the development of skin tumors.

18 Nov 2013

Close to 100 novel human gene regions that code for proteins may be linked to cancer

By using a new analysis method, researchers at Karolinska Institutet and Science for Life Laboratory (SciLifeLab) in Sweden have found close to one hundred novel human gene regions that code for proteins. A number of these regions are so-called pseudogenes, which may be linked to cancer.