Clinical Trial News and Research

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Real-world study finds lower weight loss with GLP-1 drugs due to early discontinuation

A Cleveland Clinic study shows that semaglutide and tirzepatide – injectable GLP-1 drugs for obesity – produce smaller weight loss in a real-world setting because patients discontinue treatment or use lower maintenance dosages.

10 Jun 2025

Dr. Stephen Ross’s research into psychedelic medicine expands therapeutic frontiers

In a comprehensive Genomic Press Interview published today, Dr. Stephen Ross, a leading figure in psychedelic medicine at New York University (NYU), reveals how a serendipitous conversation in 2006 launched his journey into investigating psychedelic compounds as potential breakthrough treatments for some of psychiatry's most challenging conditions.

10 Jun 2025

Study reveals the genetic underpinnings of a rare and aggressive ovarian cancer

A new study explains the genetic underpinnings of a rare and aggressive form of ovarian cancer – and offers a potential pathway for new treatments.

9 Jun 2025

School-based cavity treatments help stop tooth decay in children

Two topical treatments applied to kids' cavities can stop the majority of them from progressing for years, according to a study led by NYU College of Dentistry and published in JAMA Network Open.

9 Jun 2025

Glioblastoma patients live longer with triple treatment strategy

A new study led by Keck Medicine of USC researchers may have uncovered an effective combination therapy for glioblastoma, a brain tumor diagnosis with few available effective treatments.

9 Jun 2025

Structured exercise strengthens immune response in cancer treatment

Exercising during chemotherapy and before surgery may help the body send more immune cells into cancerous tumors, according to a first-of-its-kind pilot study from the University of Surrey and Royal Surrey NHS Foundation Trust.

9 Jun 2025

Symptom provocation may boost effectiveness of repetitive transcranial magnetic stimulation

A new study in JAMA Psychiatry makes the case that symptom provocation may significantly improve the clinical effectiveness of repetitive transcranial magnetic stimulation (rTMS), a noninvasive brain stimulation method used to treat depression, obsessive-compulsive disorder (OCD) and nicotine dependence.

6 Jun 2025

Mitochondrial DNA variant predicts resistance to melanoma immunotherapy

Results from a new study help resolve the decade-long mystery of why many patients with the deadliest form of skin cancer do not respond to the latest cancer treatments.

6 Jun 2025

Statins linked to lower death rates in critically ill sepsis patients

Sepsis is when the immune system overshoots its inflammatory reaction to an infection, so strongly that the vital organs begin to shut down.

6 Jun 2025

Healthy diet improves metabolism even without weight loss

Nearly one-third of people who adopted and adhered to a healthy diet did not lose any weight, but still reaped many health benefits, according to a new study led by researchers at Harvard T.H. Chan School of Public Health and Ben Gurion University, Israel.

6 Jun 2025

Transcendental Meditation may offer lasting benefits for heart health in high-risk Black adults

A newly published randomized controlled trial in Frontiers in Medicine has found that the practice of Transcendental Meditation® (TM) may significantly reduce the risk of major adverse cardiovascular events (MACE) in Black men and women at high risk for heart disease.

5 Jun 2025

Early heart ultrasound may predict birth complications in babies

An echocardiography of the baby's little heart soon after the onset of labour can predict the outcome of the birth and in particular whether the baby will adequately tolerate the contractions or will be more likely to go into distress, necessitating a caesarean section or an operative delivery.

5 Jun 2025

Study: Deceased-donor kidney transplants do not benefit all patients equally

A major international study, being presented today at the 62nd ERA Congress, reveals that the long-accepted survival advantage of deceased-donor kidney transplantation does not extend equally to every patient and every donor organ.

5 Jun 2025

Genetic mutation identified as key factor in immunotherapy resistance for melanoma

Tests in 1,225 patients with the most deadly form of skin cancer reveal for the first time a genetic trait among most of those who did not respond to the latest cancer treatments, known as immune checkpoint inhibitors.

5 Jun 2025

DANTE trial reveals promising outcomes for shortened immunotherapy in advanced melanoma

Reducing the length of immunotherapy treatment for an advanced skin cancer did not significantly diminish disease control when compared to giving treatments over a longer period, according to breakthrough research led by the Universities of Sheffield and Leeds and Sheffield Teaching Hospitals NHS Foundation Trust.

5 Jun 2025

Nicotinamide riboside shows promise in treating Werner syndrome symptoms

Werner syndrome (WS) is a rare genetic disorder that causes premature aging and serious complications. In the first clinical trial of its kind, researchers from Japan with the company Niagen Bioscience, investigated the effects of nicotinamide riboside (NR), a vitamin B3 derivative, in patients with WS.

5 Jun 2025

P2Y12 inhibitors linked to lower rates of cardiovascular events compared to aspirin

Giving a P2Y12 inhibitor anti-clotting drug to patients with coronary artery disease is associated with lower rates of cardiovascular death, heart attack and stroke compared with traditional aspirin, with no increased risk of major bleeding, finds a study published by The BMJ today.

5 Jun 2025

Type 2 diabetes drug shows improvements for patients with progressive liver disease

The sodium glucose cotransporter 2 (SGLT-2) inhibitor drug dapagliflozin, widely used to treat type 2 diabetes, also shows improvements for patients with progressive liver disease, finds a clinical trial from China published by The BMJ today.

5 Jun 2025

Statins show no additional benefit for depression treatment

Lipid-lowering medicines, known as statins, are prescribed in cases of high cholesterol levels, to reduce the risk of atherosclerosis, heart attack and stroke.

4 Jun 2025

AI-designed drug shows early promise for lung fibrosis patients in clinical trial

Researchers report that rentosertib, an AI-discovered TNIK inhibitor, showed promising safety and potential to improve lung function in patients with idiopathic pulmonary fibrosis in a 12-week phase 2a clinical trial. The highest dose group demonstrated a trend toward increased forced vital capacity, especially among patients not receiving standard antifibrotic therapy, supporting further clinical investigation.

4 Jun 2025

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Clinical Trial News and Research

Real-world study finds lower weight loss with GLP-1 drugs due to early discontinuation

Dr. Stephen Ross’s research into psychedelic medicine expands therapeutic frontiers

Study reveals the genetic underpinnings of a rare and aggressive ovarian cancer

School-based cavity treatments help stop tooth decay in children

Glioblastoma patients live longer with triple treatment strategy

Structured exercise strengthens immune response in cancer treatment

Symptom provocation may boost effectiveness of repetitive transcranial magnetic stimulation

Mitochondrial DNA variant predicts resistance to melanoma immunotherapy

Statins linked to lower death rates in critically ill sepsis patients

Healthy diet improves metabolism even without weight loss

Transcendental Meditation may offer lasting benefits for heart health in high-risk Black adults

Early heart ultrasound may predict birth complications in babies

Study: Deceased-donor kidney transplants do not benefit all patients equally

Genetic mutation identified as key factor in immunotherapy resistance for melanoma

DANTE trial reveals promising outcomes for shortened immunotherapy in advanced melanoma

Nicotinamide riboside shows promise in treating Werner syndrome symptoms

P2Y12 inhibitors linked to lower rates of cardiovascular events compared to aspirin

Type 2 diabetes drug shows improvements for patients with progressive liver disease

Statins show no additional benefit for depression treatment

AI-designed drug shows early promise for lung fibrosis patients in clinical trial

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